Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects expressionEXP 6480464CTDFluorouracil affects the expression of RELA proteinPMID:18535404
Relaincreases expressionEXP 6480464CTDFluorouracil results in increased expression of RELA proteinPMID:34665902 PMID:34800596
Relamultiple interactionsEXP 6480464CTDBosentan inhibits the reaction [Fluorouracil results in increased expression of RELA protein]; Thymol inhibits the reaction [Fluorouracil results in increased expression of RELA protein]PMID:34665902 PMID:34800596
Relaaffects response to substanceISORELA (Homo sapiens)6480464CTDRELA protein affects the susceptibility to FluorouracilPMID:15548681
Reladecreases expressionISORELA (Homo sapiens)6480464CTDFluorouracil results in decreased expression of RELA proteinPMID:19003803
Reladecreases response to substanceISORELA (Homo sapiens)6480464CTDRELA protein results in decreased susceptibility to FluorouracilPMID:15548681 PMID:16680372 PMID:22905237
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDFluorouracil results in increased phosphorylation of RELA proteinPMID:26310874
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[N(1),N(11)-diethylnorspermine co-treated with Fluorouracil] affects the localization of RELA protein; [N(1),N(11)-diethylnorspermine co-treated with Fluorouracil] results in decreased expression of [NFKB1 protein binds to RELA protein]; Fluorouracil affects the localization of and affects the activity of RELA protein; resveratrol inhibits the reaction [Fluorouracil results in increased phosphorylation of RELA protein]PMID:12941601 PMID:16637064 PMID:26310874
Relamultiple interactionsISORela (Mus musculus)6480464CTDFluorouracil inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]PMID:16724238
Go Back to source page   Continue to Ontology report