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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases activityISORela (Mus musculus)6480464CTDFluoxetine results in increased activity of RELA proteinPMID:16413968
Relamultiple interactionsISORela (Mus musculus)6480464CTDFluoxetine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]PMID:21575647
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