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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889 Species: Rattus norvegicus RGD Object: Gene Symbol: Rela Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Acc ID: CHEBI:28177 Term: theophylline Definition: A dimethylxanthine having the two methyl groups located at positions 1 and 3. CasRN: 58-55-9 Chemical ID: MESH:D013806

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1352761	6480464	CTD	Theophylline inhibits the reaction [TNF protein results in increased expression of RELA protein]	PMID:11770011
affects localization	ISO	RGD:1352761	6480464	CTD	Theophylline affects the localization of RELA protein	PMID:11770011