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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:15343
Term: acetaldehyde
Definition: The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
Chemical ID: MESH:D000079
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases expressionEXP 6480464CTDAcetaldehyde results in increased expression of RELA proteinPMID:14722113
Relamultiple interactionsEXP 6480464CTDAcetaldehyde promotes the reaction [RELA protein binds to COL2A1 promoter]; Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]; Pentoxifylline inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased activity of [NFKB1 protein binds to RELA protein]]PMID:14722113 PMID:17952619
Relaaffects localizationISORELA (Homo sapiens)6480464CTDAcetaldehyde affects the localization of RELA proteinPMID:14619338
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDAcetaldehyde results in increased activity of [RELA protein binds to NFKB1 protein]PMID:10799556
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