GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rela | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of RELA mRNA | PMID:33387578 | Rela | affects expression | ISO | Rela (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of RELA mRNA | PMID:17562736 | Rela | decreases activity | ISO | Rela (Mus musculus) | 6480464 | CTD | Acetaminophen results in decreased activity of RELA protein | PMID:18835260 | Rela | increases expression | ISO | Rela (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased expression of RELA mRNA; Acetaminophen results in increased expression of RELA protein | PMID:12540782 PMID:25949234 PMID:29697884 | Rela | increases phosphorylation | ISO | Rela (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased phosphorylation of RELA protein | PMID:25265579 PMID:31697998 | Rela | multiple interactions | ISO | Rela (Mus musculus) | 6480464 | CTD | [[Acetaminophen results in increased activity of NFKBIB protein] which affects the localization of and results in increased activity of RELA protein] which results in increased expression of IL6 mRNA; [Acetaminophen results in increased activity of NFKBIB protein] which affects the localization of and results in increased activity of RELA protein; [vadimezan affects the reaction [P2RX1 protein affects the susceptibility to Acetaminophen]] which affects the phosphorylation of RELA protein; Acetaminophen affects the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein; amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein]; Chlorogenic Acid inhibits the reaction [Acetaminophen results in increased expression of and results in increased phosphorylation of and affects the localization of RELA protein]; lophirone B inhibits the reaction [Acetaminophen results in increased expression of RELA protein]; lophirone C inhibits the reaction [Acetaminophen results in increased expression of RELA protein]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of RELA mRNA]; Plant Preparations inhibits the reaction [Acetaminophen results in decreased activity of RELA protein]; saikosaponin D inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein] | PMID:12540782 PMID:18835260 PMID:25265579 PMID:26079055 PMID:29697884 PMID:31697998 PMID:34726736 PMID:37046119 PMID:9281604 | | ||||||||||||||||||||||
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