GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rela | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of RELA mRNA; Indomethacin results in increased expression of RELA protein | PMID:28648817 PMID:30580614 | Rela | multiple interactions | EXP | | 6480464 | CTD | [morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of RELA mRNA]; [Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of RELA mRNA]; Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of RELA protein]; Indomethacin promotes the reaction [morin inhibits the reaction [Freund's Adjuvant results in increased expression of RELA protein]]; morin promotes the reaction [Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of RELA protein]]; paeonol inhibits the reaction [Indomethacin results in increased expression of RELA mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA protein]; Silymarin inhibits the reaction [Indomethacin results in increased expression of RELA protein] | PMID:19251492 PMID:25698669 PMID:28648817 PMID:30580614 | Rela | affects localization | ISO | RELA (Homo sapiens) | 6480464 | CTD | Indomethacin affects the localization of RELA protein | PMID:18059344 | Rela | decreases activity | ISO | Rela (Mus musculus) | 6480464 | CTD | Indomethacin results in decreased activity of RELA protein | PMID:15579461 | Rela | multiple interactions | ISO | RELA (Homo sapiens) | 6480464 | CTD | Indomethacin inhibits the reaction [LTA protein results in increased phosphorylation of RELA protein]; Indomethacin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Indomethacin inhibits the reaction [TNF protein results in increased activity of RELA protein] | PMID:15489888 PMID:17873517 | | ||||||||||||||||||||||
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