GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rela | increases activity | EXP | | 6480464 | CTD | Copper results in increased activity of RELA protein | PMID:16987042 | Rela | multiple interactions | EXP | | 6480464 | CTD | [Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of RELA protein]; tempol inhibits the reaction [Copper results in increased activity of RELA protein] | PMID:16987042 PMID:34577062 | Rela | increases phosphorylation | ISO | Rela (Mus musculus) | 6480464 | CTD | Copper analog results in increased phosphorylation of RELA protein | PMID:21319953 | Rela | multiple interactions | ISO | RELA (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in decreased expression of RELA protein modified form; [Chelating Agents binds to Copper] which results in decreased phosphorylation of RELA protein; [Chelating Agents binds to Copper] which results in increased expression of RELA mRNA; RELA mRNA affects the reaction [Copper results in increased expression of CXCL8 mRNA]; RELA mRNA affects the reaction [Copper results in increased expression of GCLC mRNA]; RELA mRNA affects the reaction [Copper results in increased expression of HMOX1 mRNA]; RELA mRNA affects the reaction [Copper results in increased expression of IER3 mRNA]; RELA mRNA affects the reaction [Copper results in increased expression of SRXN1 mRNA]; RELA mRNA affects the reaction [Copper results in increased expression of ZFAND2A mRNA] | PMID:19747488 PMID:30911355 | Rela | multiple interactions | ISO | Rela (Mus musculus) | 6480464 | CTD | [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; [Copper co-treated with Lead co-treated with Cadmium co-treated with Zinc co-treated with Mercury co-treated with Chromium co-treated with Manganese co-treated with Nickel] results in increased expression of RELA protein | PMID:23690655 PMID:28035397 | | ||||||||||||||||||||||
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