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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:15864
Term: luteolin
Definition: A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3', 4', 5 and 7. It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an anti-inflammatory agent and an immune system modulator as well as being active against several cancers.
Chemical ID: MESH:D047311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDLuteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]PMID:18090225
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDLuteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]; Luteolin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased phosphorylation of and affects the localization of RELA protein]; Luteolin inhibits the reaction [chromium hexavalent ion results in increased activity of and affects the localization of RELA protein]; Luteolin inhibits the reaction [Glucose affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein affects the localization of RELA protein]; Luteolin inhibits the reaction [TNF protein results in increased activity of RELA protein]PMID:15113938 PMID:15334063 PMID:19557821 PMID:25448439 PMID:30133131 PMID:34217685
Relamultiple interactionsISORela (Mus musculus)6480464CTDLuteolin inhibits the reaction [Cisplatin results in increased expression of RELA protein]; Luteolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]PMID:23770416 PMID:37390879
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