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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases expressionEXP 6480464CTDepigallocatechin gallate results in decreased expression of RELA proteinPMID:27659729
Relamultiple interactionsEXP 6480464CTD[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein]; epigallocatechin gallate inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein]PMID:30368989
Relaincreases phosphorylationISORela (Mus musculus)6480464CTDepigallocatechin gallate results in increased phosphorylation of RELA proteinPMID:35863485
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein]; epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of RELA protein]; epigallocatechin gallate inhibits the reaction [Glucose affects the localization of RELA protein]; epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]; epigallocatechin gallate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein]PMID:19557821 PMID:24508477 PMID:26187476 PMID:31252129
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