Sirt6 (sirtuin 6) - Rat Genome Database

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Pathways
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Gene: Sirt6 (sirtuin 6) Rattus norvegicus
Analyze
Symbol: Sirt6
Name: sirtuin 6
RGD ID: 1305216
Description: Enables protein lysine deacetylase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to peptide hormone stimulus; and post-embryonic cardiac muscle cell growth involved in heart morphogenesis. Predicted to be located in chromosome, subtelomeric region and nucleoplasm. Predicted to be part of pericentric heterochromatin. Predicted to be active in endoplasmic reticulum; nucleus; and site of double-strand break. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (sirtuin 6); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299638; MGC114368; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,733,056 - 8,738,543 (+)NCBIGRCr8
mRatBN7.278,082,312 - 8,087,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,082,364 - 8,098,914 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx710,968,768 - 10,974,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,844,434 - 12,849,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,711,823 - 10,717,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
base-excision repair  (ISO)
cardiac muscle cell differentiation  (ISO)
cellular response to angiotensin  (IEP)
cellular response to endothelin  (IEP)
cellular response to hydrogen peroxide  (IEP)
chromatin remodeling  (ISO)
circadian regulation of gene expression  (ISO)
determination of adult lifespan  (ISO)
DNA repair-dependent chromatin remodeling  (ISO)
double-strand break repair  (ISO)
glucose homeostasis  (ISO)
ketone biosynthetic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of protein import into nucleus  (ISO)
negative regulation of protein localization to chromatin  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,ISO)
negative regulation of transcription elongation by RNA polymerase II  (ISO)
pericentric heterochromatin formation  (ISO)
positive regulation of blood vessel branching  (ISO)
positive regulation of chondrocyte proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of double-strand break repair  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to chromatin  (ISO)
positive regulation of stem cell differentiation  (ISO)
positive regulation of stem cell population maintenance  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
post-embryonic cardiac muscle cell growth involved in heart morphogenesis  (IMP)
post-translational protein modification  (IEA)
protein destabilization  (ISO)
protein localization to site of double-strand break  (ISO)
regulation of circadian rhythm  (ISO)
regulation of double-strand break repair via homologous recombination  (ISO)
regulation of lipid catabolic process  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
response to nutrient levels  (IEP)
response to UV  (ISO)
retrotransposon silencing  (ISO)
subtelomeric heterochromatin formation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling. Guo J, etal., Circ Res. 2019 May 10;124(10):1448-1461. doi: 10.1161/CIRCRESAHA.118.314032.
3. Dietary restriction increases site-specific histone H3 acetylation in rat liver: possible modulation by sirtuins. Kawakami K, etal., Biochem Biophys Res Commun. 2012 Feb 24;418(4):836-40. doi: 10.1016/j.bbrc.2012.01.120. Epub 2012 Jan 31.
4. Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia. Lee OH, etal., Biochem Biophys Res Commun. 2013 Aug 23;438(2):388-94. doi: 10.1016/j.bbrc.2013.07.085. Epub 2013 Jul 27.
5. The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats. Luo LL, etal., Aging Clin Exp Res. 2012 Apr;24(2):125-33. doi: 10.3275/7660. Epub 2011 Apr 14.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
13. Obesity accelerates ovarian follicle development and follicle loss in rats. Wang N, etal., Metabolism. 2014 Jan;63(1):94-103. doi: 10.1016/j.metabol.2013.09.001. Epub 2013 Oct 14.
14. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. Yang SJ, etal., PLoS One. 2011 Feb 23;6(2):e17057.
15. Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat. Yao L, etal., Cell Rep. 2017 Jul 18;20(3):641-654. doi: 10.1016/j.celrep.2017.06.069.
16. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-kappaB-dependent transcriptional activity. Yu SS, etal., Br J Pharmacol. 2013 Jan;168(1):117-28. doi: 10.1111/j.1476-5381.2012.01903.x.
Additional References at PubMed
PMID:12477932   PMID:15795229   PMID:16079181   PMID:16439206   PMID:18242175   PMID:18337721   PMID:19135889   PMID:19913571   PMID:20141841   PMID:21847107   PMID:22449973   PMID:23201774  
PMID:23217706   PMID:23566837   PMID:24063863   PMID:24105743   PMID:24495875   PMID:24510807   PMID:25475987   PMID:25819580   PMID:26732053   PMID:26786260   PMID:27016702   PMID:27094368  
PMID:27457971   PMID:27534902   PMID:28130175   PMID:30671172   PMID:31115579   PMID:32311231   PMID:32394287   PMID:32445068   PMID:32745152   PMID:33444676   PMID:34663177   PMID:34923569  
PMID:35562171   PMID:35767210   PMID:36275897   PMID:36490326   PMID:36720357   PMID:36728900   PMID:37199639   PMID:37626845   PMID:37668962  


Genomics

Comparative Map Data
Sirt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,733,056 - 8,738,543 (+)NCBIGRCr8
mRatBN7.278,082,312 - 8,087,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,082,364 - 8,098,914 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx710,968,768 - 10,974,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,844,434 - 12,849,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,711,823 - 10,717,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
SIRT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,174,109 - 4,182,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,174,109 - 4,182,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,174,106 - 4,182,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,106 - 4,133,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,125,105 - 4,133,596NCBI
Celera194,113,565 - 4,122,051 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,937,486 - 3,945,942 (-)NCBIHuRef
CHM1_1194,173,652 - 4,182,142 (-)NCBICHM1_1
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBIT2T-CHM13v2.0
Sirt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,457,621 - 81,463,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,457,619 - 81,463,631 (-)EnsemblGRCm39 Ensembl
GRCm381081,621,787 - 81,627,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,621,785 - 81,627,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,084,531 - 81,090,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361081,024,916 - 81,030,687 (-)NCBIMGSCv36mm8
Celera1082,644,967 - 82,650,787 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sirt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,644,023 - 4,650,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,641,883 - 4,650,518 (+)NCBIChiLan1.0ChiLan1.0
SIRT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,146,057 - 4,154,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensemblpanpan1.1panPan2
SIRT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,412,989 - 55,424,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,412,646 - 55,424,944 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,140,555 - 55,152,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,071,820 - 56,083,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,072,611 - 56,083,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,131,653 - 55,143,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,612,837 - 55,624,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,811,751 - 55,823,816 (+)NCBIUU_Cfam_GSD_1.0
Sirt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,440,673 - 215,447,621 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,386,977 - 2,394,096 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,387,162 - 2,394,066 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,568,493 - 74,577,772 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,568,539 - 74,577,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,063,186 - 75,071,642 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,924,230 - 3,932,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,924,230 - 3,932,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,286,733 - 4,295,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,442,057 - 5,451,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,441,973 - 5,449,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt6
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:64
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000008758
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH128538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,087,420 - 8,087,622 (+)MAPPERmRatBN7.2
Rnor_6.0710,942,693 - 10,942,894NCBIRnor6.0
Rnor_5.0711,111,819 - 11,112,020UniSTSRnor5.0
RGSC_v3.479,560,340 - 9,560,541UniSTSRGSC3.4
Celera76,278,496 - 6,278,697UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 31 16 15 16 1 74 31 38 11
Low 8 26 25 4 25 8 10 4 3 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001031649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC098923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008758   ⟹   ENSRNOP00000008758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,082,364 - 8,098,914 (+)Ensembl
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119590   ⟹   ENSRNOP00000095912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,082,547 - 8,087,776 (+)Ensembl
RefSeq Acc Id: NM_001031649   ⟹   NP_001026819
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,117 - 8,738,543 (+)NCBI
mRatBN7.278,082,349 - 8,087,776 (+)NCBI
Rnor_6.0710,937,622 - 10,943,048 (+)NCBI
Rnor_5.0711,106,748 - 11,112,174 (+)NCBI
RGSC_v3.479,555,269 - 9,560,695 (+)RGD
Celera76,273,425 - 6,278,851 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078666   ⟹   XP_038934594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,294 - 8,738,543 (+)NCBI
mRatBN7.278,082,796 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_039078667   ⟹   XP_038934595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,294 - 8,738,543 (+)NCBI
mRatBN7.278,082,519 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_039078669   ⟹   XP_038934597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,087 - 8,738,543 (+)NCBI
mRatBN7.278,082,312 - 8,087,776 (+)NCBI
RefSeq Acc Id: XM_063263182   ⟹   XP_063119252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,056 - 8,738,543 (+)NCBI
RefSeq Acc Id: XM_063263183   ⟹   XP_063119253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,280 - 8,738,543 (+)NCBI
RefSeq Acc Id: XM_063263184   ⟹   XP_063119254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,280 - 8,738,543 (+)NCBI
RefSeq Acc Id: XM_063263185   ⟹   XP_063119255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,294 - 8,738,543 (+)NCBI
RefSeq Acc Id: XM_063263186   ⟹   XP_063119256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,082 - 8,738,543 (+)NCBI
RefSeq Acc Id: XM_063263187   ⟹   XP_063119257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,734,141 - 8,738,543 (+)NCBI
RefSeq Acc Id: XM_063263188   ⟹   XP_063119258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,733,418 - 8,738,543 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001026819   ⟸   NM_001031649
- UniProtKB: Q4FZY2 (UniProtKB/TrEMBL),   A6K863 (UniProtKB/TrEMBL),   F7EVU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008758   ⟸   ENSRNOT00000008758
RefSeq Acc Id: XP_038934597   ⟸   XM_039078669
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038934595   ⟸   XM_039078667
- Peptide Label: isoform X5
- UniProtKB: A0A8I6APP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934594   ⟸   XM_039078666
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000095912   ⟸   ENSRNOT00000119590
RefSeq Acc Id: XP_063119252   ⟸   XM_063263182
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119256   ⟸   XM_063263186
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063119253   ⟸   XM_063263183
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119254   ⟸   XM_063263184
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119255   ⟸   XM_063263185
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063119258   ⟸   XM_063263188
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063119257   ⟸   XM_063263187
- Peptide Label: isoform X7
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZY2-F1-model_v2 AlphaFold Q4FZY2 1-330 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694965
Promoter ID:EPDNEW_R5489
Type:initiation region
Name:Sirt6_1
Description:sirtuin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0710,937,645 - 10,937,705EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305216 AgrOrtholog
BioCyc Gene G2FUF-35046 BioCyc
Ensembl Genes ENSRNOG00000006393 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008758 ENTREZGENE
  ENSRNOT00000008758.6 UniProtKB/TrEMBL
  ENSRNOT00000119590.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.200 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7461534 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_histone_deAcase_SIR2 UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report rno:299638 UniProtKB/TrEMBL
MGC_CLONE MGC:114368 IMAGE-MGC_LOAD
NCBI Gene 299638 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PhenoGen Sirt6 PhenoGen
PROSITE SIRTUIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006393 RatGTEx
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A8I6APP5 ENTREZGENE, UniProtKB/TrEMBL
  A6K863 ENTREZGENE, UniProtKB/TrEMBL
  F7EVU3 ENTREZGENE, UniProtKB/TrEMBL
  Q4FZY2 ENTREZGENE
UniProt Secondary Q4FZY2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt6  sirtuin 6  Sirt6  sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Sirt6  sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)  Sirt6  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Sirt6  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)  Sirt6_predicted  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sirt6_predicted  sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED