Sirt6 (sirtuin 6) - Rat Genome Database

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Gene: Sirt6 (sirtuin 6) Mus musculus
Analyze
Symbol: Sirt6
Name: sirtuin 6
RGD ID: 1313111
MGI Page MGI
Description: Enables several functions, including NAD+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; and TORC2 complex binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of nucleobase-containing compound metabolic process; and regulation of protein localization. Located in nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2810449N18Rik; AI043036; mSIRT6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacylase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2-like protein 6; Sir2l6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,457,621 - 81,463,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,457,619 - 81,463,631 (-)EnsemblGRCm39 Ensembl
GRCm381081,621,787 - 81,627,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,621,785 - 81,627,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,084,531 - 81,090,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361081,024,916 - 81,030,687 (-)NCBIMGSCv36mm8
Celera1082,644,967 - 82,650,787 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
base-excision repair  (IMP)
cardiac muscle cell differentiation  (IMP)
cellular response to angiotensin  (ISO)
cellular response to endothelin  (ISO)
cellular response to hydrogen peroxide  (ISO)
chromatin organization  (IEA)
chromatin remodeling  (ISO)
circadian regulation of gene expression  (IMP)
determination of adult lifespan  (IMP,ISO)
DNA damage response  (IEA)
DNA repair  (IEA)
DNA repair-dependent chromatin remodeling  (IDA)
double-strand break repair  (ISO)
glucose homeostasis  (IMP)
ketone biosynthetic process  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (IMP)
negative regulation of gene expression, epigenetic  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of glucose import  (IMP)
negative regulation of glycolytic process  (IMP,ISO)
negative regulation of protein import into nucleus  (IMP)
negative regulation of protein localization to chromatin  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IMP,ISO)
negative regulation of transcription elongation by RNA polymerase II  (IDA)
pericentric heterochromatin formation  (ISO)
positive regulation of blood vessel branching  (ISO)
positive regulation of chondrocyte proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of double-strand break repair  (IDA,ISO)
positive regulation of fat cell differentiation  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of insulin secretion  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (IDA,ISO)
positive regulation of protein localization to chromatin  (IDA,IMP)
positive regulation of stem cell differentiation  (IMP,ISO)
positive regulation of stem cell population maintenance  (ISO)
positive regulation of stem cell proliferation  (IMP)
positive regulation of telomere maintenance  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
post-embryonic cardiac muscle cell growth involved in heart morphogenesis  (ISO)
protein destabilization  (IMP,ISO)
protein localization to site of double-strand break  (ISO)
regulation of circadian rhythm  (IMP)
regulation of double-strand break repair via homologous recombination  (ISO)
regulation of lipid catabolic process  (IMP)
regulation of lipid metabolic process  (IDA)
regulation of protein localization to plasma membrane  (ISO)
regulation of protein secretion  (ISO)
response to nutrient levels  (ISO)
response to UV  (ISO)
retrotransposon silencing  (IDA,IMP)
subtelomeric heterochromatin formation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal cornea physiology  (IAGP)
abnormal corneal stroma morphology  (IAGP)
abnormal electroretinogram waveform feature  (IAGP)
abnormal eye morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal nursing  (IAGP)
abnormal spleen physiology  (IAGP)
colitis  (IAGP)
corneal scarring  (IAGP)
corneal vascularization  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral density  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased total body fat amount  (IAGP)
early cellular replicative senescence  (IAGP)
hepatic steatosis  (IAGP)
hypoglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
increased cellular sensitivity to alkylating agents  (IAGP)
increased cellular sensitivity to ionizing radiation  (IAGP)
increased circulating cholesterol level  (IEA)
increased circulating glucose level  (IAGP)
increased cornea thickness  (IAGP)
increased insulin sensitivity  (IAGP)
increased liver weight  (IAGP)
increased mean corpuscular hemoglobin concentration  (IEA)
increased susceptibility to age-related retinal degeneration  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lordokyphosis  (IAGP)
male infertility  (IAGP)
malocclusion  (IAGP)
narrow eye opening  (IAGP)
postnatal growth retardation  (IAGP)
premature aging  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced female fertility  (IAGP)
spleen hypoplasia  (IAGP)
spontaneous chromosome breakage  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling. Guo J, etal., Circ Res. 2019 May 10;124(10):1448-1461. doi: 10.1161/CIRCRESAHA.118.314032.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Decreased expression of sirtuin 6 is associated with release of high mobility group box-1 after cerebral ischemia. Lee OH, etal., Biochem Biophys Res Commun. 2013 Aug 23;438(2):388-94. doi: 10.1016/j.bbrc.2013.07.085. Epub 2013 Jul 27.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
7. Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Puttagunta R, etal., Genome Res 2000 Sep;10(9):1369-80.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
12. Obesity accelerates ovarian follicle development and follicle loss in rats. Wang N, etal., Metabolism. 2014 Jan;63(1):94-103. doi: 10.1016/j.metabol.2013.09.001. Epub 2013 Oct 14.
13. Activation of peroxisome proliferator-activated receptor gamma by rosiglitazone increases sirt6 expression and ameliorates hepatic steatosis in rats. Yang SJ, etal., PLoS One. 2011 Feb 23;6(2):e17057.
14. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-kappaB-dependent transcriptional activity. Yu SS, etal., Br J Pharmacol. 2013 Jan;168(1):117-28. doi: 10.1111/j.1476-5381.2012.01903.x.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15795229   PMID:16141072   PMID:16141073   PMID:16439206   PMID:16602821  
PMID:17967808   PMID:18242175   PMID:18388907   PMID:18799693   PMID:18824292   PMID:19135889   PMID:19220062   PMID:20047575   PMID:20059953   PMID:20141841   PMID:20644252   PMID:20816089  
PMID:20847051   PMID:21098266   PMID:21677750   PMID:21680843   PMID:21871212   PMID:21873635   PMID:22083510   PMID:22367546   PMID:23041974   PMID:23076146   PMID:23086477   PMID:23086953  
PMID:23142079   PMID:23217706   PMID:23552949   PMID:23553536   PMID:23761075   PMID:23881913   PMID:23911928   PMID:23974119   PMID:24012758   PMID:24013546   PMID:24043303   PMID:24063863  
PMID:24105743   PMID:24149372   PMID:24638860   PMID:24896097   PMID:25009184   PMID:25066211   PMID:25083875   PMID:25247314   PMID:25320180   PMID:25366464   PMID:25543188   PMID:25688369  
PMID:25915124   PMID:26063178   PMID:26189760   PMID:26191269   PMID:26362183   PMID:26403315   PMID:26471901   PMID:26481302   PMID:26629408   PMID:26639398   PMID:26761436   PMID:26775341  
PMID:26786260   PMID:26924042   PMID:26940461   PMID:27045575   PMID:27058938   PMID:27156849   PMID:27180906   PMID:27189179   PMID:27249230   PMID:27322069   PMID:27421859   PMID:27457971  
PMID:27568560   PMID:27601447   PMID:27841758   PMID:28039864   PMID:28250020   PMID:28329681   PMID:28351995   PMID:28355287   PMID:28355558   PMID:28355567   PMID:28385723   PMID:28406396  
PMID:28448551   PMID:28536120   PMID:28607107   PMID:28644902   PMID:28723567   PMID:28765271   PMID:28856570   PMID:28860594   PMID:28871079   PMID:28928419   PMID:28951325   PMID:29049850  
PMID:29129519   PMID:29217762   PMID:29317652   PMID:29319170   PMID:29322219   PMID:29373150   PMID:29387864   PMID:29402409   PMID:29474172   PMID:29555651   PMID:29688375   PMID:29698567  
PMID:29717979   PMID:30030453   PMID:30070973   PMID:30166529   PMID:30189861   PMID:30256390   PMID:30429089   PMID:30514106   PMID:30530497   PMID:30630525   PMID:30700227   PMID:30782483  
PMID:30794635   PMID:30841754   PMID:30853213   PMID:30912134   PMID:30926765   PMID:30943401   PMID:31002797   PMID:31063699   PMID:31113929   PMID:31194993   PMID:31216030   PMID:31295533  
PMID:31318577   PMID:31372634   PMID:31399301   PMID:31399344   PMID:31442424   PMID:31541078   PMID:31603194   PMID:31603249   PMID:31744885   PMID:31787254   PMID:31851938   PMID:31967391  
PMID:31972266   PMID:32002721   PMID:32049548   PMID:32239217   PMID:32265492   PMID:32278654   PMID:32290105   PMID:32305562   PMID:32394328   PMID:32535965   PMID:32580272   PMID:32584788  
PMID:32599221   PMID:32642006   PMID:32701506   PMID:32912518   PMID:32915773   PMID:33006225   PMID:33089974   PMID:33274005   PMID:33353368   PMID:33464650   PMID:33516881   PMID:33583107  
PMID:33600943   PMID:33619381   PMID:33760202   PMID:33934090   PMID:34050173   PMID:34077730   PMID:34122724   PMID:34425214   PMID:34493807   PMID:34666304   PMID:34708231   PMID:34744793  
PMID:34793336   PMID:34920961   PMID:35123854   PMID:35150745   PMID:35157928   PMID:35167876   PMID:35235147   PMID:35302398   PMID:35379817   PMID:35443857   PMID:35506565   PMID:35526796  
PMID:35547746   PMID:35563783   PMID:35668088   PMID:35798905   PMID:35842903   PMID:35859073   PMID:35978508   PMID:36036554   PMID:36057401   PMID:36057627   PMID:36208355   PMID:36208627  
PMID:36356655   PMID:36367517   PMID:36414111   PMID:36496445   PMID:36565979   PMID:36653345   PMID:36720357   PMID:36988243   PMID:37146480   PMID:37185874   PMID:37198221   PMID:37394473  
PMID:37445896   PMID:37550003   PMID:37582706   PMID:37598403   PMID:37603612   PMID:37607939   PMID:37634527   PMID:37736721   PMID:37871034   PMID:37914087   PMID:37936548   PMID:38135684  
PMID:38288355   PMID:38296191   PMID:38332150  


Genomics

Comparative Map Data
Sirt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,457,621 - 81,463,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,457,619 - 81,463,631 (-)EnsemblGRCm39 Ensembl
GRCm381081,621,787 - 81,627,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,621,785 - 81,627,797 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,084,531 - 81,090,353 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361081,024,916 - 81,030,687 (-)NCBIMGSCv36mm8
Celera1082,644,967 - 82,650,787 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
SIRT6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,174,109 - 4,182,563 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,174,109 - 4,182,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,174,106 - 4,182,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,106 - 4,133,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,125,105 - 4,133,596NCBI
Celera194,113,565 - 4,122,051 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,937,486 - 3,945,942 (-)NCBIHuRef
CHM1_1194,173,652 - 4,182,142 (-)NCBICHM1_1
T2T-CHM13v2.0194,157,416 - 4,165,866 (-)NCBIT2T-CHM13v2.0
Sirt6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,733,056 - 8,738,543 (+)NCBIGRCr8
mRatBN7.278,082,312 - 8,087,776 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,082,364 - 8,098,914 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx710,968,768 - 10,974,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0712,844,434 - 12,849,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,711,823 - 10,717,248 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0710,937,622 - 10,943,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,937,599 - 10,943,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,106,748 - 11,112,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,555,269 - 9,560,695 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,555,269 - 9,560,695 (+)NCBI
Celera76,273,425 - 6,278,851 (+)NCBICelera
Cytogenetic Map7q11NCBI
Sirt6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554954,644,023 - 4,650,083 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554954,641,883 - 4,650,518 (+)NCBIChiLan1.0ChiLan1.0
SIRT6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2208,570,110 - 8,578,621 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,800,265 - 7,808,774 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0193,196,092 - 3,204,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1194,146,057 - 4,154,132 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl194,146,057 - 4,154,126 (-)Ensemblpanpan1.1panPan2
SIRT6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,412,989 - 55,424,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,412,646 - 55,424,944 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,140,555 - 55,152,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,071,820 - 56,083,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,072,611 - 56,083,837 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,131,653 - 55,143,673 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02055,612,837 - 55,624,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02055,811,751 - 55,823,816 (+)NCBIUU_Cfam_GSD_1.0
Sirt6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,440,673 - 215,447,621 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365882,386,977 - 2,394,096 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365882,387,162 - 2,394,066 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl274,568,493 - 74,577,772 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1274,568,539 - 74,577,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,063,186 - 75,071,642 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,924,230 - 3,932,583 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,924,230 - 3,932,590 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660814,286,733 - 4,295,705 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,442,057 - 5,451,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,441,973 - 5,449,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt6
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:840
Count of miRNA genes:462
Interacting mature miRNAs:531
Transcripts:ENSMUST00000042923, ENSMUST00000119324, ENSMUST00000126477, ENSMUST00000143424
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse

Markers in Region
UniSTS:236417  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,621,813 - 81,622,012UniSTSGRCm38
MGSCv371081,084,558 - 81,084,757UniSTSGRCm37
Celera1082,644,994 - 82,645,193UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
AI043036  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,622,114 - 81,622,244UniSTSGRCm38
MGSCv371081,084,859 - 81,084,989UniSTSGRCm37
Celera1082,645,295 - 82,645,425UniSTS
Cytogenetic Map10C1UniSTS
cM Map1043.0UniSTS
Whitehead/MRC_RH10917.97UniSTS
Sirt6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371081,084,730 - 81,084,967UniSTSGRCm37
Celera1082,645,166 - 82,645,403UniSTS
Cytogenetic Map10C1UniSTS
cM Map1039.72UniSTS
cM Map1043.0UniSTS
Sirt6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,621,985 - 81,622,222UniSTSGRCm38
MGSCv371081,084,730 - 81,084,967UniSTSGRCm37
Celera1082,645,166 - 82,645,403UniSTS
Cytogenetic Map10C1UniSTS
cM Map1039.72UniSTS
Sirt6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042923   ⟹   ENSMUSP00000048971
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,457,621 - 81,463,631 (-)Ensembl
GRCm38.p6 Ensembl1081,621,787 - 81,627,797 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119324   ⟹   ENSMUSP00000113953
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,457,619 - 81,463,154 (-)Ensembl
GRCm38.p6 Ensembl1081,621,785 - 81,627,320 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126477
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,461,361 - 81,463,400 (-)Ensembl
GRCm38.p6 Ensembl1081,625,527 - 81,627,566 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143424   ⟹   ENSMUSP00000118238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,461,613 - 81,463,091 (-)Ensembl
GRCm38.p6 Ensembl1081,625,779 - 81,627,257 (-)Ensembl
RefSeq Acc Id: NM_001163430   ⟹   NP_001156902
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,457,621 - 81,463,156 (-)NCBI
GRCm381081,621,787 - 81,627,322 (-)NCBI
MGSCv371081,084,531 - 81,090,353 (-)RGD
Celera1082,644,967 - 82,650,787 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001378944   ⟹   NP_001365873
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,457,621 - 81,463,400 (-)NCBI
GRCm381081,621,787 - 81,627,566 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001378945   ⟹   NP_001365874
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,457,621 - 81,463,400 (-)NCBI
GRCm381081,621,787 - 81,627,566 (-)NCBI
Sequence:
RefSeq Acc Id: NM_181586   ⟹   NP_853617
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,457,621 - 81,463,400 (-)NCBI
GRCm381081,621,787 - 81,627,566 (-)NCBI
MGSCv371081,084,531 - 81,090,353 (-)RGD
Celera1082,644,967 - 82,650,787 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_166193
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,457,621 - 81,463,400 (-)NCBI
GRCm381081,621,787 - 81,627,566 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011243507   ⟹   XP_011241809
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,459,177 - 81,463,631 (-)NCBI
GRCm381081,623,346 - 81,627,792 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_853617   ⟸   NM_181586
- Peptide Label: isoform 1
- UniProtKB: P59941 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156902   ⟸   NM_001163430
- Peptide Label: isoform 2
- UniProtKB: Q3UKP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011241809   ⟸   XM_011243507
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001365873   ⟸   NM_001378944
- Peptide Label: isoform 1
- UniProtKB: P59941 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001365874   ⟸   NM_001378945
- Peptide Label: isoform 2
- UniProtKB: Q3UKP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000113953   ⟸   ENSMUST00000119324
RefSeq Acc Id: ENSMUSP00000118238   ⟸   ENSMUST00000143424
RefSeq Acc Id: ENSMUSP00000048971   ⟸   ENSMUST00000042923
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59941-F1-model_v2 AlphaFold P59941 1-334 view protein structure

Promoters
RGD ID:6819915
Promoter ID:MM_KWN:5033
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000119324,   OTTMUST00000075440,   OTTMUST00000075479,   OTTMUST00000075480
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361081,089,351 - 81,091,257 (-)MPROMDB
RGD ID:8672838
Promoter ID:EPDNEW_M14450
Type:initiation region
Name:Sirt6_1
Description:Mus musculus sirtuin 6 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381081,627,550 - 81,627,610EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354161 AgrOrtholog
Ensembl Genes ENSMUSG00000034748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000042923 ENTREZGENE
  ENSMUST00000042923.9 UniProtKB/Swiss-Prot
  ENSMUST00000119324 ENTREZGENE
  ENSMUST00000119324.8 UniProtKB/TrEMBL
  ENSMUST00000143424.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sirtuin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50721 UniProtKB/Swiss-Prot
MGD MGI:1354161 ENTREZGENE
NCBI Gene 50721 ENTREZGENE
PANTHER NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sirt6 PhenoGen
PROSITE SIRTUIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YY89_MOUSE UniProtKB/TrEMBL
  P59941 ENTREZGENE
  Q3UKP1 ENTREZGENE, UniProtKB/TrEMBL
  SIR6_MOUSE UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-06 Sirt6  sirtuin 6    sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED