RGD Reference Report - Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. - Rat Genome Database

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Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.

Authors: Puttagunta, R  Gordon, LA  Meyer, GE  Kapfhamer, D  Lamerdin, JE  Kantheti, P  Portman, KM  Chung, WK  Jenne, DE  Olsen, AS  Burmeister, M 
Citation: Puttagunta R, etal., Genome Res 2000 Sep;10(9):1369-80.
RGD ID: 1556640
Pubmed: PMID:10984455   (View Abstract at PubMed)
PMCID: PMC310909   (View Article at PubMed Central)

A cosmid/bacterial artificial chromosome (BAC) contiguous (contig) map of human chromosome (HSA) 19p13.3 has been constructed, and over 50 genes have been localized to the contig. Genes and anonymous ESTs from approximately 4000 kb of human 19p13.3 were placed on the central mouse chromosome 10 map by genetic mapping and pulsed-field gel electrophoresis (PFGE) analysis. A region of approximately 2500 kb of HSA 19p13.3 is collinear to mouse chromosome (MMU) 10. In contrast, the adjacent approximately 1200 kb are inverted. Two genes are located in a 50-kb region after the inversion on MMU 10, followed by a region of homology to mouse chromosome 17. The synteny breakpoint and one of the inversion breakpoints has been localized to sequenced regions in human <5 kb in size. Both breakpoints are rich in simple tandem repeats, including (TCTG)n, (CT)n, and (GTCTCT)n, suggesting that simple repeat sequences may be involved in chromosome breaks during evolution. The overall size of the region in mouse is smaller, although no large regions are missing. Comparing the physical maps to the genetic maps showed that in contrast to the higher-than-average rate of genetic recombination in gene-rich telomeric region on HSA 19p13.3, the average rate of recombination is lower than expected in the homologous mouse region. This might indicate that a hot spot of recombination may have been lost in mouse or gained in human during evolution, or that the position of sequences along the chromosome (telomeric compared to the middle of a chromosome) is important for recombination rates.

Objects referenced in this article
Gene Amh anti-Mullerian hormone Mus musculus
Gene Ankrd24 ankyrin repeat domain 24 Mus musculus
Gene Ap3d1 adaptor-related protein complex 3, delta 1 subunit Mus musculus
Gene Bsg basigin Mus musculus
Gene Cdc34 cell division cycle 34 Mus musculus
Gene Cela2a chymotrypsin-like elastase family, member 2A Mus musculus
Gene Cfd complement factor D Mus musculus
Gene Cirbp cold inducible RNA binding protein Mus musculus
Gene Creb3l3 cAMP responsive element binding protein 3-like 3 Mus musculus
Gene Dapk3 death-associated protein kinase 3 Mus musculus
Gene Efna2 ephrin A2 Mus musculus
Gene Gna11 guanine nucleotide binding protein, alpha 11 Mus musculus
Gene Gna15 guanine nucleotide binding protein, alpha 15 Mus musculus
Gene Gng7 guanine nucleotide binding protein (G protein), gamma 7 Mus musculus
Gene Gpx4 glutathione peroxidase 4 Mus musculus
Gene Gzmm granzyme M (lymphocyte met-ase 1) Mus musculus
Gene Hmg20b high mobility group 20B Mus musculus
Gene Map2k2 mitogen-activated protein kinase kinase 2 Mus musculus
Gene Matk megakaryocyte-associated tyrosine kinase Mus musculus
Gene Nfyb nuclear transcription factor-Y beta Mus musculus
Gene Oaz1 ornithine decarboxylase antizyme 1 Mus musculus
Gene Pcsk4 proprotein convertase subtilisin/kexin type 4 Mus musculus
Gene Ptbp1 polypyrimidine tract binding protein 1 Mus musculus
Gene Shc2 SHC (Src homology 2 domain containing) transforming protein 2 Mus musculus
Gene Sirt6 sirtuin 6 Mus musculus
Gene Tbxa2r thromboxane A2 receptor Mus musculus
Gene Tcf3 transcription factor 3 Mus musculus
Gene Thop1 thimet oligopeptidase 1 Mus musculus
Gene Tle5 TLE family member 5, transcriptional modulator Mus musculus

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