GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt6 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of SIRT6 protein | PMID:34713381 | Sirt6 | increases response to substance | EXP | | 6480464 | CTD | SIRT6 gene mutant form results in increased susceptibility to Doxorubicin | PMID:34713381 | Sirt6 | multiple interactions | EXP | | 6480464 | CTD | SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of CAT mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of CAT protein]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of FAS mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of FASL mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of GPX1 mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of PRDX5 mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of SOD2 mRNA]; SIRT6 protein promotes the reaction [Doxorubicin results in decreased expression of RIPK1 protein] | PMID:34713381 | Sirt6 | decreases expression | ISO | Sirt6 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in decreased expression of SIRT6 protein | PMID:34713381 | Sirt6 | multiple interactions | ISO | Sirt6 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin inhibits the reaction [SIRT6 protein binds to FAS promoter]; Doxorubicin inhibits the reaction [SIRT6 protein binds to FASLG promoter]; Doxorubicin promotes the reaction [SIRT6 protein binds to TP53 protein]; SIRT6 protein inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to FAS promoter]]; SIRT6 protein inhibits the reaction [Doxorubicin promotes the reaction [TP53 protein binds to FASLG promoter]]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of GPX1 mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of HMGB1 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of PRDX5 mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of SOD2 mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased acetylation of TP53 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased cleavage of CASP8 protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FADD protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG protein modified form]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of RIPK1 protein modified form]; SIRT6 protein inhibits the reaction [Doxorubicin results in increased expression of RIPK3 protein] | PMID:34713381 | | ||||||||||||||||||||||
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