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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationEXP 6480464CTDlead acetate affects the localization of RELA proteinPMID:22728154 PMID:25088297
Relaincreases expressionEXP 6480464CTDlead acetate results in increased expression of RELA mRNA; lead acetate results in increased expression of RELA proteinPMID:37866543
Relamultiple interactionsEXP 6480464CTDAscorbic Acid inhibits the reaction [lead acetate affects the localization of RELA protein]; Proanthocyanidins inhibits the reaction [lead acetate affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of RELA protein]; Quercetin inhibits the reaction [lead acetate affects the localization of RELA protein]PMID:22728154 PMID:25088297 PMID:37866543
Relaaffects localizationISORela (Mus musculus)6480464CTDlead acetate affects the localization of RELA proteinPMID:24530660
Reladecreases expressionISORela (Mus musculus)6480464CTDlead acetate results in decreased expression of RELA mRNAPMID:24260418
Relaincreases expressionISORela (Mus musculus)6480464CTDlead acetate results in increased expression of RELA mRNA; lead acetate results in increased expression of RELA proteinPMID:24260418 PMID:36539177 PMID:37385299
Relamultiple interactionsISORela (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of RELA protein]; 3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of RELA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of RELA protein]; lead acetate results in increased phosphorylation of and results in increased expression of RELA protein; pyrrolidine dithiocarbamic acid inhibits the reaction [lead acetate results in increased expression of RELA protein]; U 0126 inhibits the reaction [lead acetate results in increased expression of RELA protein]PMID:24530660 PMID:36539177 PMID:37385299
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