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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationISORELA (Homo sapiens)6480464CTDHistamine affects the localization of RELA proteinPMID:11336536
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDHistamine results in increased phosphorylation of RELA proteinPMID:29452068
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDGlycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]; Histamine promotes the reaction [Lipopolysaccharides affects the localization of RELA protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; Histamine results in increased activity of [CXCL8 protein binds to RELA protein]PMID:11336536 PMID:29452068 PMID:9609743
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