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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:2979
Term: baicalein
Definition: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
Chemical ID: MESH:C006680
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationISORELA (Homo sapiens)6480464CTDbaicalein affects the localization of RELA proteinPMID:29481769
Reladecreases localizationISORELA (Homo sapiens)6480464CTDbaicalein results in decreased localization of RELA proteinPMID:21803068
Reladecreases phosphorylationISORELA (Homo sapiens)6480464CTDbaicalein results in decreased phosphorylation of RELA proteinPMID:33838155
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDMIR3663 mRNA promotes the reaction [baicalein results in decreased phosphorylation of RELA protein]; NKILA mRNA promotes the reaction [baicalein affects the localization of RELA protein]PMID:29481769 PMID:33838155
Relamultiple interactionsISORela (Mus musculus)6480464CTDbaicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] affects the localization of RELA protein]; baicalein inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]PMID:20850421 PMID:22369883
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