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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889 Species: Rattus norvegicus RGD Object: Gene Symbol: Rela Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Acc ID: CHEBI:8107 Term: phenytoin Definition: A imidazolidine-2,4-dione that consists of hydantoin bearing two phenyl substituents at position 5. CasRN: 57-41-0 Chemical ID: MESH:D010672

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1352761	6480464	CTD	Phenytoin inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased localization of and results in increased activity of RELA protein]	PMID:10700573
increases activity	ISO	RGD:1551095	6480464	CTD	Phenytoin results in increased activity of RELA protein	PMID:15322231