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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:78741
Term: oxidopamine
Definition: A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Chemical ID: MESH:D016627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDOxidopamine results in increased localization of and results in increased activity of RELA protein; SN50 peptide inhibits the reaction [Oxidopamine results in increased localization of RELA protein]PMID:17368433
Relaaffects localizationISORELA (Homo sapiens)6480464CTDOxidopamine affects the localization of RELA proteinPMID:31247335
Relaincreases activityISORELA (Homo sapiens)6480464CTDOxidopamine results in increased activity of RELA proteinPMID:20851755
Relaincreases phosphorylationISORela (Mus musculus)6480464CTDOxidopamine results in increased phosphorylation of RELA proteinPMID:29054324
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDN-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl)piperidin-1-yl)propan-2-yl)-2-naphthamide inhibits the reaction [Oxidopamine affects the localization of RELA protein]PMID:31247335
Relamultiple interactionsISORela (Mus musculus)6480464CTDchrysin inhibits the reaction [Oxidopamine results in increased phosphorylation of RELA protein]PMID:29054324
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