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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases activityEXP 6480464CTDCocaine results in increased activity of RELA proteinPMID:19183502
Relamultiple interactionsEXP 6480464CTDSCH 23390 inhibits the reaction [Cocaine results in increased activity of RELA protein]PMID:19183502
Relaincreases localizationISORela (Mus musculus)6480464CTDCocaine results in increased localization of RELA proteinPMID:20354174
Relamultiple interactionsISORela (Mus musculus)6480464CTDacetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; AG 1879 inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; Cocaine promotes the reaction [RELA protein binds to CCL2 promoter]; Cocaine results in increased activity of and affects the localization of RELA protein; Cocaine results in increased phosphorylation of and results in increased activity of RELA protein; GPX1 protein inhibits the reaction [Cocaine affects the localization of RELA protein]; GPX1 protein inhibits the reaction [Cocaine results in increased activity of and affects the localization of RELA protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; RELA mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]PMID:20354174 PMID:31059705
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