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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDGenistein inhibits the reaction [Ethanol results in increased activity of RELA protein]; Genistein inhibits the reaction [Fructose affects the localization of RELA protein]PMID:21704028 PMID:23274713
Reladecreases expressionISORELA (Homo sapiens)6480464CTDGenistein results in decreased expression of RELA proteinPMID:21078540
Reladecreases expressionISORela (Mus musculus)6480464CTDGenistein results in decreased expression of RELA proteinPMID:21078540
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDGenistein inhibits the reaction [Oxygen deficiency affects the localization of RELA protein]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of RELA mRNA]; Genistein promotes the reaction [arsenic trioxide results in decreased expression of RELA protein]PMID:21078540 PMID:23452621
Relamultiple interactionsISORela (Mus musculus)6480464CTD[Genistein co-treated with arsenic trioxide] results in decreased expression of RELA protein; Genistein inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]PMID:18274639 PMID:21078540
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