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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects expressionEXP 6480464CTDPioglitazone affects the expression of RELA mRNA; Pioglitazone affects the expression of RELA proteinPMID:28744220
Relamultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Pioglitazone affects the expression of RELA mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Pioglitazone affects the expression of RELA protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; Pioglitazone inhibits the reaction [Aldosterone results in increased activity of RELA protein]; Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; T 0070907 inhibits the reaction [Pioglitazone affects the expression of RELA mRNA]; T 0070907 inhibits the reaction [Pioglitazone affects the expression of RELA protein]PMID:18660453 PMID:28744220 PMID:36988379 PMID:37044004
Relamultiple interactionsISORela (Mus musculus)6480464CTDpioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]PMID:17015710
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