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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:69581
Term: Paeonol
Definition: A methoxybenzene that has formula C9H10O3.
Chemical ID: MESH:C013638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDpaeonol inhibits the reaction [Epirubicin results in increased phosphorylation of RELA protein]; paeonol inhibits the reaction [Indomethacin results in increased expression of RELA mRNA]PMID:29505745 PMID:30580614
Relamultiple interactionsISORela (Mus musculus)6480464CTD[paeonol inhibits the reaction [[CHUK protein binds to IKBKB protein] which results in increased degradation of NFKBIA protein]] which affects the localization of RELA protein; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]; paeonol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of RELA protein]PMID:22542583
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