ion transport inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	ion transport inhibitor	go back to main search page
Accession:	CHEBI:50184	browse the term
Definition:	A compound which inhibits the movement of an ion across an energy-transducing cell membrane.
Synonyms:	related_synonym:	ion transport inhibitors

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Rat (275) Mouse (274) Human (279) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (275)

dihydroouabain

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions
increases expression

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]
dihydroouabain results in increased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 17A

multiple interactions

dihydroouabain results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17F

multiple interactions

dihydroouabain results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482

G

neuronal PAS domain protein 2

increases expression
multiple interactions

dihydroouabain results in increased expression of NPAS2 mRNA
dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

RAR-related orphan receptor C

multiple interactions
increases expression

dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

erastin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acrosin binding protein

increases expression

erastin results in increased expression of ACRBP mRNA alternative form

NCBI chr 4:157,851,149...157,864,211
Ensembl chr 4:157,841,841...157,864,213

G

autophagy related 5

increases expression

erastin results in increased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

biglycan

multiple interactions
decreases expression

BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]; erastin inhibits the reaction [[Antineoplastic Agents, Immunological results in decreased susceptibility to Antineoplastic Agents, Immunological] which results in increased expression of BGN mRNA alternative form]
erastin results in decreased expression of BGN mRNA alternative form

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

multiple interactions
increases expression

GW 506033X inhibits the reaction [erastin results in increased expression of CHAC1 mRNA]

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

collagen type I alpha 2 chain

increases expression

erastin results in increased expression of COL1A2 mRNA alternative form

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

erastin affects the reaction [CYP2E1 protein affects the susceptibility to Ethanol]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

erastin promotes the reaction [Silicon Dioxide results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [erastin results in increased expression of DDIT3 mRNA]

PMID:30817950 PMID:37075931

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

denticleless E3 ubiquitin protein ligase homolog

increases expression

erastin results in increased expression of DTL mRNA alternative form

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases phosphorylation

GW 506033X inhibits the reaction [erastin results in increased phosphorylation of ERN1 protein]

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

FA complementation group D2

decreases expression

erastin results in decreased expression of FANCD2 protein

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

fumarate hydratase

decreases response to substance

FH protein results in decreased susceptibility to erastin

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

ferritin heavy chain 1

multiple interactions
increases expression

3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]; Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]
[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]

PMID:32937103 PMID:37951334

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

multiple interactions

[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

erastin results in increased expression of GCLM protein
NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

gap junction protein, alpha 1

multiple interactions

GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutathione peroxidase 4

decreases expression
multiple interactions

erastin results in decreased expression of GPX4 protein
erastin promotes the reaction [Silicon Dioxide results in decreased expression of GPX4 protein]
astaxanthine inhibits the reaction [erastin results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [erastin results in decreased expression of GPX4 protein]; gap 27 peptide inhibits the reaction [erastin results in decreased expression of GPX4 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of GPX4 protein]; SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein]

PMID:31323261 PMID:32937103 PMID:34785303 PMID:37075931 PMID:37648051

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

heme oxygenase 1

increases expression

erastin results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HRas proto-oncogene, GTPase

increases response to substance

HRAS protein modified form results in increased susceptibility to erastin

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

erastin results in increased expression of HSPA5 protein
erastin promotes the reaction [Silicon Dioxide results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

decreases phosphorylation

erastin results in decreased phosphorylation of HSPB1 protein

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

microtubule-associated protein 1 light chain 3 beta

increases expression
multiple interactions

erastin results in increased expression of MAP1LC3B protein modified form
3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

erastin results in increased phosphorylation of MAPK1 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation
multiple interactions

erastin results in increased phosphorylation of MAPK8 protein
GW 506033X inhibits the reaction [erastin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

marker of proliferation Ki-67

decreases expression
multiple interactions

erastin results in decreased expression of MKI67 protein
BGN mRNA alternative form inhibits the reaction [erastin results in decreased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutS homolog 2

increases expression

erastin results in increased expression of MSH2 mRNA alternative form

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

nuclear receptor coactivator 4

decreases expression
multiple interactions

erastin results in decreased expression of NCOA4 protein
[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]
3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]; Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]

PMID:32937103 PMID:37951334

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

nuclear factor of activated T-cells 2

multiple interactions

erastin promotes the reaction [Silicon Dioxide results in increased expression of NFATC2 protein]

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
erastin results in increased expression of NFE2L2 protein
NFE2L2 protein promotes the reaction [erastin results in increased expression of FTH1 protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]

PMID:31323261 PMID:32937103

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

protein kinase D2

affects response to substance
multiple interactions

PRKD2 protein affects the susceptibility to erastin
[PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the abundance of Malondialdehyde; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein; [PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]

NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions
decreases expression

erastin results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 protein
Quercetin inhibits the reaction [erastin results in increased expression of PTGS2 protein]; Quercetin promotes the reaction [erastin results in decreased expression of PTGS2 protein]
Vitamin E inhibits the reaction [erastin analog results in increased expression of PTGS2 mRNA]
erastin analog results in increased expression of PTGS2 mRNA; erastin results in increased expression of PTGS2 mRNA

PMID:24439385 PMID:32937103 PMID:37230155

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

sterol-C5-desaturase

increases expression

erastin results in increased expression of SC5D mRNA alternative form

NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273

G

sestrin 1

multiple interactions

SESN1 protein inhibits the reaction [erastin results in decreased expression of GPX4 protein]

NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697

G

sestrin 2

multiple interactions
increases expression

NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]
erastin results in increased expression of SESN2 mRNA; erastin results in increased expression of SESN2 protein
Acetylcysteine inhibits the reaction [erastin results in increased expression of SESN2 protein]; Butylated Hydroxyanisole inhibits the reaction [erastin results in increased expression of SESN2 protein]; Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA]; Deferoxamine inhibits the reaction [erastin results in increased expression of SESN2 protein]; diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein]; ferrostatin-1 inhibits the reaction [erastin results in increased expression of SESN2 protein]; NFE2L2 protein affects the reaction [erastin results in increased expression of SESN2 protein]

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 11 member 2

increases expression

erastin results in increased expression of SLC11A2 protein

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 40 member 1

decreases expression
increases expression

erastin results in decreased expression of SLC40A1 protein
erastin results in increased expression of SLC40A1 protein

PMID:31323261 PMID:32937103

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 7 member 11

increases expression
multiple interactions
decreases expression

erastin results in increased expression of SLC7A11 mRNA
erastin promotes the reaction [Silicon Dioxide results in decreased expression of SLC7A11 protein]
erastin results in decreased expression of SLC7A11 protein
gap 27 peptide inhibits the reaction [erastin results in decreased expression of SLC7A11 protein]; GJA1 protein affects the reaction [erastin results in decreased expression of SLC7A11 protein]
NFE2L2 protein promotes the reaction [erastin results in increased expression of SLC7A11 mRNA]

PMID:32937103 PMID:34785303 PMID:37075931

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

TATA-box binding protein associated factor, RNA polymerase I subunit A

decreases expression

erastin results in decreased expression of TAF1A mRNA alternative form

NCBI chr13:95,012,160...95,048,131
Ensembl chr13:95,029,225...95,048,087

G

transferrin

increases expression
multiple interactions

erastin results in increased expression of TF mRNA; erastin results in increased expression of TF protein
Quercetin inhibits the reaction [erastin results in increased expression of TF mRNA]; Quercetin inhibits the reaction [erastin results in increased expression of TF protein]

PMID:32937103 PMID:37230155

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

increases expression

erastin results in increased expression of TFRC protein

PMID:31323261 PMID:32937103

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

TIMP metallopeptidase inhibitor 1

decreases expression

erastin results in decreased expression of TIMP1 mRNA alternative form

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

voltage-dependent anion channel 2

decreases expression
affects binding
increases degradation

erastin results in decreased expression of VDAC2 protein
erastin analog binds to VDAC2 protein
erastin results in increased degradation of VDAC2 protein

PMID:17568748 PMID:32937103

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

G

voltage-dependent anion channel 3

increases degradation
decreases expression
affects response to substance

erastin results in increased degradation of VDAC3 protein
erastin results in decreased expression of VDAC3 protein
VDAC3 protein affects the susceptibility to erastin

PMID:17568748 PMID:32937103

NCBI chr16:69,434,982...69,451,473
Ensembl chr16:69,435,005...69,451,471

G

WD repeat domain 41

decreases expression

erastin results in decreased expression of WDR41 mRNA alternative form

NCBI chr 2:26,222,797...26,273,849
Ensembl chr 2:26,224,495...26,273,836

G

Wnt family member 5A

multiple interactions
increases expression

erastin promotes the reaction [Silicon Dioxide results in increased expression of WNT5A protein]
erastin results in increased expression of WNT5A protein

NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234

etacrynic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions
decreases response to substance

GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Ethacrynic Acid]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases transport

ABCC2 protein results in increased transport of Ethacrynic Acid

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

aldo-keto reductase family 1, member C1

increases expression

Ethacrynic Acid results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 7, member A2

multiple interactions

Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

Bcl2-like 1

increases expression
multiple interactions

Ethacrynic Acid results in increased expression of BCL2L1 protein
[arsenic trioxide co-treated with Ethacrynic Acid] results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 5

multiple interactions

[arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions

[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein; [MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]] which results in increased cleavage of CASP3 protein; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases cleavage

[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP8 protein
Ethacrynic Acid results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases cleavage
multiple interactions

Ethacrynic Acid results in increased cleavage of CASP9 protein
arsenic trioxide promotes the reaction [Ethacrynic Acid results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

CAT mutant form promotes the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

multiple interactions

Ethacrynic Acid inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cyclin D1

decreases expression

Ethacrynic Acid results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

increases expression

Ethacrynic Acid results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CASP8 and FADD-like apoptosis regulator

multiple interactions
decreases expression

arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of CFLAR protein]

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

Ethacrynic Acid results in increased expression of CYP1A1 mRNA
Ethacrynic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]

PMID:9973208 PMID:18493746

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]
Ethacrynic Acid results in increased expression of DDIT3 mRNA; Ethacrynic Acid results in increased expression of DDIT3 protein

PMID:17171638 PMID:25817893 PMID:35724838

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

fibronectin 1

decreases expression

Ethacrynic Acid results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Ethacrynic Acid results in increased expression of FOS mRNA

PMID:10407097 PMID:12946577

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

frizzled class receptor 5

increases expression

Ethacrynic Acid results in increased expression of FZD5 mRNA

NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Ethacrynic Acid

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutathione S-transferase alpha 1

decreases response to substance
increases expression
multiple interactions
affects metabolic processing

GSTA1 protein results in decreased susceptibility to Ethacrynic Acid
Ethacrynic Acid results in increased expression of GSTA1 mRNA
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid
GSTA1 protein affects the metabolism of Ethacrynic Acid analog

PMID:1985777 PMID:9799558 PMID:9877184 PMID:12781783

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

affects metabolic processing
multiple interactions

GSTA2 protein affects the metabolism of Ethacrynic Acid
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 4

increases expression
affects metabolic processing

Ethacrynic Acid results in increased expression of GSTA4 mRNA; Ethacrynic Acid results in increased expression of GSTA4 protein
GSTA4 protein affects the metabolism of Ethacrynic Acid

PMID:2619714 PMID:9799558

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase mu 1

affects metabolic processing

GSTM1 protein affects the metabolism of Ethacrynic Acid

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

decreases activity
affects metabolic processing
decreases response to substance
increases expression
multiple interactions

Ethacrynic Acid analog results in decreased activity of GSTP1 protein; Ethacrynic Acid results in decreased activity of GSTP1 protein
GSTP1 protein affects the metabolism of Ethacrynic Acid
GSTP1 protein results in decreased susceptibility to Ethacrynic Acid
GSTP1 protein affects the metabolism of Ethacrynic Acid analog
Ethacrynic Acid results in increased expression of GSTP1 protein
Ethacrynic Acid binds to and results in decreased activity of GSTP1 protein; Ethacrynic Acid inhibits the reaction [Chlorophyllides inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]]; Ethacrynic Acid inhibits the reaction [GSTP1 protein affects the metabolism of Isotretinoin]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Ethacrynic Acid]; GSTP1 protein results in decreased susceptibility to [arsenic trioxide co-treated with Ethacrynic Acid]; Pyrimethamine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Quinine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]; Tetracycline inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]

PMID:2619714 PMID:2747627 PMID:9463521 PMID:9806904 PMID:9877184 More...

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 2

affects metabolic processing

GSTT2 protein affects the metabolism of Ethacrynic Acid

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

glutathione S-transferase zeta 1

affects metabolic processing

GSTZ1 protein affects the metabolism of Ethacrynic Acid

NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284

G

heme oxygenase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of HMOX1 protein]; Deferoxamine inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]
Ethacrynic Acid results in increased expression of HMOX1 mRNA; Ethacrynic Acid results in increased expression of HMOX1 protein

PMID:20934533 PMID:25817893 PMID:26945724 PMID:35724838

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock transcription factor 1

increases activity

Ethacrynic Acid results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

intercellular adhesion molecule 1

multiple interactions

Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions

Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Ethacrynic Acid co-treated with arsenic trioxide] results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with arsenic trioxide] results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

lymphoid enhancer binding factor 1

decreases expression
affects binding

Ethacrynic Acid results in decreased expression of LEF1 mRNA
Ethacrynic Acid binds to LEF1 protein

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

mitogen activated protein kinase kinase 1

increases expression

Ethacrynic Acid results in increased expression of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase 14

decreases expression

Ethacrynic Acid results in decreased expression of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases expression

Ethacrynic Acid results in increased expression of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases expression

Ethacrynic Acid results in decreased expression of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

[MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]] which results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; CAT mutant form promotes the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form results in increased susceptibility to [Ethacrynic Acid co-treated with arsenic trioxide]; pyrazolanthrone inhibits the reaction [arsenic trioxide promotes the reaction [Ethacrynic Acid results in decreased expression of MCL1 protein]]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization
affects response to substance
increases expression

NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Ethacrynic Acid]
Ethacrynic Acid results in increased expression of and affects the localization of NFE2L2 protein; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Ethacrynic Acid
Ethacrynic Acid results in increased expression of NFE2L2 protein

PMID:19303893 PMID:20932822 PMID:20934533 PMID:25817893 PMID:26945724 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

increases expression

Ethacrynic Acid results in increased expression of NGF mRNA

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions

Ethacrynic Acid promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

multiple interactions

[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[arsenic trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Ethacrynic Acid inhibits the reaction [IL1B protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 12 member 2

decreases activity
multiple interactions

Ethacrynic Acid results in decreased activity of SLC12A2 protein
Ethacrynic Acid inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

sulfiredoxin 1

increases expression

Ethacrynic Acid results in increased expression of SRXN1 protein

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

tumor necrosis factor

multiple interactions

Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; Ethacrynic Acid inhibits the reaction [TNF protein affects the localization of RELA protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

increases expression
multiple interactions

Ethacrynic Acid results in increased expression of TNFAIP3 protein
Ethacrynic Acid inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; Ethacrynic Acid inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

tumor protein p53

affects localization

Ethacrynic Acid affects the localization of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

X-linked inhibitor of apoptosis

multiple interactions

[arsenic trioxide co-treated with Ethacrynic Acid] results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

metolazone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

nuclear receptor subfamily 1, group I, member 2

increases activity
multiple interactions

Metolazone results in increased activity of NR1I2 protein
[Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

ouabain

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

affects expression

Ouabain affects the expression of A2M protein

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily B member 1A

multiple interactions
increases expression

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA acyltransferase 2

affects expression

Ouabain affects the expression of ACAA2 protein

NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249

G

angiotensin I converting enzyme

affects expression

Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

actin alpha 2, smooth muscle

affects expression

Ouabain affects the expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

affects expression

Ouabain affects the expression of ADH1C protein

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

angiotensinogen

affects expression
increases expression

Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein

PMID:11768735 PMID:16565308

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

decreases expression
affects expression

Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

apoptosis inducing factor, mitochondria associated 1

increases expression

Ouabain results in increased expression of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

annexin A1

affects expression

Ouabain affects the expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A2

affects expression

Ouabain affects the expression of ANXA2 protein

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

apoptotic peptidase activating factor 1

increases expression

Ouabain results in increased expression of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

Ouabain results in decreased expression of ARAF mRNA

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

ariadne RBR E3 ubiquitin protein ligase 1

decreases expression

Ouabain results in decreased expression of ARIH1 mRNA

NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245

G

actin related protein 2/3 complex, subunit 5

affects expression

Ouabain affects the expression of ARPC5 protein

NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410

G

arrestin, beta 1

increases expression

Ouabain results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

N-acylsphingosine amidohydrolase 1

affects expression

Ouabain affects the expression of ASAH1 protein

NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233

G

activating transcription factor 6 beta

increases expression

Ouabain results in increased expression of ATF6B protein

NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894

G

ATM serine/threonine kinase

increases phosphorylation

Ouabain results in increased phosphorylation of ATM protein

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase H+/K+ transporting non-gastric alpha2 subunit

multiple interactions

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
increases expression
affects expression
affects binding

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein

PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding

Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein

PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More...

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

increases expression
multiple interactions
decreases expression
affects expression
affects binding

Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein

PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More...

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions
increases expression

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

ATPase H+/K+ transporting subunit beta

multiple interactions

Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium]

NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063

G

ATP synthase F1 subunit alpha

affects expression

Ouabain affects the expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATR serine/threonine kinase

decreases phosphorylation

Ouabain results in decreased phosphorylation of ATR protein

NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136

G

bromo adjacent homology domain containing 1

decreases expression

Ouabain results in decreased expression of BAHD1 mRNA

NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]

PMID:17096883 PMID:18247327 PMID:31436044

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

Ouabain results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Ouabain results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BRCA1, DNA repair associated

decreases expression

Ouabain results in decreased expression of BRCA1 protein

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

calbindin 1

decreases expression

Ouabain results in decreased expression of CALB1 protein

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calmodulin-like 5

affects expression

Ouabain affects the expression of CALML5 protein

NCBI chr17:66,394,433...66,395,352

G

calcium/calmodulin-dependent protein kinase II beta

increases expression

Ouabain results in increased expression of CAMK2B protein

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

calnexin

increases expression

Ouabain results in increased expression of CANX protein

NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821

G

caspase 3

increases expression
multiple interactions
increases activity

Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein

PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

Ouabain results in increased expression of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

multiple interactions

Ouabain results in increased expression of and results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Ouabain results in increased expression of and results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity

Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression

Ouabain results in decreased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

coiled-coil domain containing 14

decreases expression

Ouabain results in decreased expression of CCDC14 mRNA

NCBI chr11:66,052,063...66,087,915
Ensembl chr11:66,052,620...66,087,956

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A1

decreases expression

Ouabain results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

decreases expression

Ouabain results in decreased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression

Ouabain results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cadherin 1

decreases expression
increases expression

Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

decreases expression

Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

decreases expression

Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein

PMID:20460749 PMID:21215801 PMID:31436044

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 6

decreases expression

Ouabain results in decreased expression of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

decreases expression
increases expression

Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein

PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

creatine kinase B

decreases activity

Ouabain results in decreased activity of CKB protein

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

claudin 1

decreases expression

Ouabain results in decreased expression of CLDN1 protein

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

canopy FGF signaling regulator 2

affects expression

Ouabain affects the expression of CNPY2 protein

NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519

G

collagen type I alpha 1 chain

multiple interactions
increases expression

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

citrate synthase

decreases activity

Ouabain results in decreased activity of CS protein

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

cytochrome c-1

multiple interactions

Ouabain results in decreased expression of and affects the localization of CYC1 protein

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

G

DNA-damage inducible transcript 3

increases expression

Ouabain results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

decreases expression

Ouabain results in decreased expression of DDOST mRNA

NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

Ouabain results in increased expression of DNAJA3 mRNA

NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161

G

dopamine receptor D1

multiple interactions
decreases expression

Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA

PMID:19626329 PMID:20132239

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

desmoglein 1

affects expression

Ouabain affects the expression of DSG1 protein

NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443

G

deoxyuridine triphosphatase

affects expression

Ouabain affects the expression of DUT protein

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

endothelin converting enzyme 1

increases expression

Ouabain results in increased expression of ECE1 protein

NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371

G

enoyl-CoA hydratase, short chain 1

affects expression

Ouabain affects the expression of ECHS1 protein

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

endothelin 1

increases expression
decreases expression

Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA

PMID:15477225 PMID:28795476

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

increases expression

Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein

PMID:15477225 PMID:16982439

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

epidermal growth factor receptor

decreases phosphorylation

Ouabain results in decreased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2A

increases expression

Ouabain results in increased expression of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 3, subunit K

affects expression

Ouabain affects the expression of EIF3K protein

NCBI chr 1:84,260,127...84,270,051
Ensembl chr 1:84,259,673...84,270,302

G

endonuclease G

increases expression

Ouabain results in increased expression of ENDOG protein

NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932

G

ERCC excision repair 4, endonuclease catalytic subunit

decreases expression

Ouabain results in decreased expression of ERCC4 mRNA

NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369

G

ETS proto-oncogene 1, transcription factor

decreases expression

Ouabain results in decreased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

Fas associated via death domain

increases expression

Ouabain results in increased expression of FADD protein

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

FA complementation group D2

multiple interactions
decreases expression

Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group F

decreases expression

Ouabain results in decreased expression of FANCF mRNA

NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923

G

FA complementation group I

decreases expression
multiple interactions

Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

phenylalanyl-tRNA synthetase 2, mitochondrial

increases expression

Ouabain results in increased expression of FARS2 mRNA

NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337

G

Fas cell surface death receptor

increases expression

Ouabain results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression

Ouabain results in increased expression of FASLG protein

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 32

multiple interactions

Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA]

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

fumarate hydratase

affects expression

Ouabain affects the expression of FH protein

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

FKBP prolyl isomerase 7

increases expression

Ouabain results in increased expression of FKBP7 mRNA

NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280

G

fibronectin 1

decreases expression

Ouabain results in decreased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

GC, vitamin D binding protein

affects expression

Ouabain affects the expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glycine receptor, beta

increases expression

Ouabain results in increased expression of GLRB mRNA

NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489

G

growth factor receptor bound protein 2

decreases expression

Ouabain results in decreased expression of GRB2 protein

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

GTP binding protein 6 (putative)

increases expression

Ouabain results in increased expression of GTPBP6 mRNA

NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873

G

H2A.X variant histone

increases phosphorylation

Ouabain results in increased phosphorylation of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

Ouabain results in increased expression of HEY1 mRNA

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hepatocyte growth factor

multiple interactions

Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
affects localization
increases activity

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heterogeneous nuclear ribonucleoprotein A2/B1

affects expression

Ouabain affects the expression of HNRNPA2B1 protein

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heterogeneous nuclear ribonucleoprotein D-like

decreases expression

Ouabain results in decreased expression of HNRNPDL mRNA

NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506

G

hippocalcin-like 1

affects expression

Ouabain affects the expression of HPCAL1 protein

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

G

histidine-rich glycoprotein

affects expression

Ouabain affects the expression of HRG protein

NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389

G

heat shock protein family A (Hsp70) member 5

increases expression

Ouabain results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

affects expression
multiple interactions

Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein

PMID:17268060 PMID:18247327

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

inhibitor of DNA binding 2

increases expression

Ouabain results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

interleukin 2 receptor subunit alpha

decreases expression

Ouabain results in decreased expression of IL2RA mRNA

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

interleukin 2 receptor subunit beta

decreases expression

Ouabain results in decreased expression of IL2RB

NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 6

increases secretion
increases expression

Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

increases expression

Ouabain results in increased expression of IL6R mRNA

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

integrin-linked kinase

decreases expression

Ouabain results in decreased expression of ILK mRNA

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

integrin subunit alpha V

decreases expression

Ouabain results in decreased expression of ITGAV mRNA

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
decreases phosphorylation

Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel subfamily D member 2

increases expression

Ouabain results in increased expression of KCND2 mRNA

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium voltage-gated channel subfamily H member 2

decreases expression
decreases activity
multiple interactions

Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]

PMID:19139152 PMID:21158687

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

lymphoid enhancer binding factor 1

decreases expression

Ouabain results in decreased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

galectin 1

affects expression
increases expression

Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein

PMID:17268060 PMID:18247327

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

LIM domain kinase 1

decreases expression

Ouabain results in decreased expression of LIMK1 mRNA

NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606

G

lanosterol synthase

increases abundance

LSS protein results in increased abundance of Ouabain

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

mitogen-activated protein kinase kinase 6

increases expression

Ouabain results in increased expression of MAP2K6 mRNA

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein

PMID:19687166 PMID:28795476

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein

PMID:19687166 PMID:28795476

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 7

multiple interactions

Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein]

NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267

G

malate dehydrogenase 2

affects expression

Ouabain affects the expression of MDH2 protein

NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271

G

MDM2 proto-oncogene

multiple interactions

Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

O-6-methylguanine-DNA methyltransferase

decreases expression

Ouabain results in decreased expression of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microRNA 29b-1

multiple interactions
decreases expression

MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

matrix metallopeptidase 13

decreases expression

Ouabain results in decreased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

decreases expression
multiple interactions

Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression

Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein

PMID:28795476 PMID:33760381

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

muscle RAS oncogene homolog

decreases expression

Ouabain results in decreased expression of MRAS mRNA

NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408

G

myocardin related transcription factor A

decreases expression

Ouabain results in decreased expression of MRTFA mRNA

NCBI chr 7:112,544,305...112,714,418
Ensembl chr 7:112,544,312...112,714,418

G

MYC proto-oncogene, bHLH transcription factor

decreases expression
increases expression

Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein

PMID:9653513 PMID:21215801

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain 12A

increases expression

Ouabain results in increased expression of MYL12A protein

NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580

G

myosin light chain kinase

decreases expression

Ouabain results in decreased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

nectin cell adhesion molecule 3

decreases expression

Ouabain results in decreased expression of NECTIN3 mRNA

NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519

G

nectin cell adhesion molecule 4

increases expression

Ouabain results in increased expression of NECTIN4 mRNA

NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709

G

neurofilament light chain

decreases expression

Ouabain results in decreased expression of NEFL mRNA

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

nitric oxide synthase 1

affects expression
increases expression

Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein

PMID:12384489 PMID:15097235

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 3

multiple interactions
affects expression
increases expression

5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein

PMID:12384489 PMID:15477225

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NPC intracellular cholesterol transporter 2

decreases expression

Ouabain results in decreased expression of NPC2 mRNA

NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155

G

natriuretic peptide A

increases expression
multiple interactions

Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]

PMID:17266992 PMID:19687166

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

NRAS proto-oncogene, GTPase

decreases expression

Ouabain results in decreased expression of NRAS mRNA

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

Parkinsonism associated deglycase

affects response to substance

PARK7 affects the susceptibility to Ouabain

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein]

PMID:24124520 PMID:31436044

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

decreases expression

Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein

PMID:20460749 PMID:21215801

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

programmed cell death 6

increases expression

Ouabain results in increased expression of PDCD6 protein

NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189

G

prefoldin subunit 5

affects expression

Ouabain affects the expression of PFDN5 protein

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

profilin 1

affects expression
decreases expression

Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein

PMID:17268060 PMID:18247327

NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631

G

plasminogen activator, urokinase receptor

decreases expression

Ouabain results in decreased expression of PLAUR mRNA

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

phospholipase C, gamma 1

decreases expression

Ouabain results in decreased expression of PLCG1 mRNA

NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330

G

palmitoyl-protein thioesterase 2

decreases expression

Ouabain results in decreased expression of PPT2 mRNA

NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

Ouabain results in decreased expression of PRKDC protein

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

proteasome 20S subunit beta 6

affects expression

Ouabain affects the expression of PSMB6 protein

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 2

decreases expression

Ouabain results in decreased expression of PTPN2 mRNA

NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627

G

RAB11B, member RAS oncogene family

increases expression

Ouabain results in increased expression of RAB11B protein

NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

Ouabain results in decreased expression of RAF1 mRNA

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS protein-specific guanine nucleotide-releasing factor 1

decreases expression

Ouabain results in decreased expression of RASGRF1 mRNA

NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269

G

regulator of G-protein signaling 2

decreases expression

Ouabain results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

ras homolog family member H

increases expression

Ouabain results in increased expression of RHOH mRNA

NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369

G

Rho-associated coiled-coil containing protein kinase 1

increases cleavage
multiple interactions

Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

multiple interactions
increases cleavage

benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

replication protein A3

affects expression

Ouabain affects the expression of RPA3 protein

NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709

G

Rpgrip1-like

decreases expression

Ouabain results in decreased expression of RPGRIP1L mRNA

NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083

G

ribosomal protein S6 kinase B1

affects expression

Ouabain affects the expression of RPS6KB1 mRNA

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ryanodine receptor 2

multiple interactions
increases response to substance

K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain]

NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142

G

S100 calcium binding protein A13

affects expression

Ouabain affects the expression of S100A13 protein

NCBI chr 2:175,999,439...176,005,933

G

S100 calcium binding protein B

increases expression

Ouabain results in increased expression of S100B protein

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression

Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA

PMID:12590200 PMID:28795476

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

serum/glucocorticoid regulated kinase 2

multiple interactions

Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]

NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480

G

serum/glucocorticoid regulated kinase family, member 3

multiple interactions

Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium]

NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476

G

SHC adaptor protein 3

increases expression

Ouabain results in increased expression of SHC3 mRNA

NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710

G

solute carrier family 16 member 1

multiple interactions

Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 22 member 12

multiple interactions

Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 5 member 5

multiple interactions

Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

G

solute carrier family 5 member 6

multiple interactions

Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin]

NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712

G

solute carrier family 8 member A1

affects response to substance
increases expression
multiple interactions

SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]

PMID:16166162 PMID:19897708

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

G

solute carrier family 9 member A1

multiple interactions
increases expression

N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

SMAD family member 4

decreases expression

Ouabain results in decreased expression of SMAD4 mRNA

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

snail family transcriptional repressor 1

decreases expression

Ouabain results in decreased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

SOS Ras/Rac guanine nucleotide exchange factor 1

decreases expression

Ouabain results in decreased expression of SOS1 protein

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SOS Ras/Rho guanine nucleotide exchange factor 2

decreases expression

Ouabain results in decreased expression of SOS2 mRNA

NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692

G

sphingosine kinase 1

decreases expression

Ouabain results in decreased expression of SPHK1 mRNA

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

transforming growth factor, beta 1

decreases expression

Ouabain results in decreased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

decreases expression

Ouabain results in decreased expression of TGFB2 mRNA

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

decreases expression

Ouabain results in decreased expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor beta receptor 3

increases expression

Ouabain results in increased expression of TGFBR3 mRNA

NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341

G

talin 1

decreases expression

Ouabain results in decreased expression of TLN1 mRNA

NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900

G

talin 2

decreases expression

Ouabain results in decreased expression of TLN2 mRNA

NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219

G

TNF receptor superfamily member 10b

increases expression

Ouabain results in increased expression of TNFRSF10A protein

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

tumor protein p53

multiple interactions

Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

affects expression

Ouabain affects the expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

tumor protein, translationally-controlled 1

affects expression

Ouabain affects the expression of TPT1 protein

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

tripartite motif containing 63

multiple interactions

[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA

NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322

G

transient receptor potential cation channel, subfamily C, member 1

increases expression

Ouabain results in increased expression of TRPC1 protein

NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276

G

transient receptor potential cation channel, subfamily C, member 6

increases expression
multiple interactions

Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]

NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092

G

twist family bHLH transcription factor 1

increases expression

Ouabain results in increased expression of TWIST1 mRNA

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

G

thioredoxin 1

affects expression

Ouabain affects the expression of TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

vimentin

decreases expression

Ouabain results in decreased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

zinc finger homeobox 3

decreases expression

Ouabain results in decreased expression of ZFHX3 mRNA

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19841
role	19817
biological role	19815
biophysical role	14053
membrane transport modulator	13897
ion transport inhibitor	275
etacrynic acid	51
metolazone	2
ouabain +	202
voltage-dependent anion channel inhibitor +	46

paths to the root