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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:4876
Term: etacrynic acid
Definition: An aromatic ether that is phenoxyacetic acid in which the phenyl ring is substituted by chlorines at positions 2 and 3, and by a 2-methylidenebutanoyl group at position 4. It is a loop diuretic used to treat high blood pressure resulting from diseases such as congestive heart failure, liver failure, and kidney failure. It is also a glutathione S-transferase (EC 2.5.1.18) inhibitor.
Chemical ID: MESH:D004976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDEthacrynic Acid affects the localization of NFE2L2 proteinPMID:20934533 PMID:25817893 PMID:26945724
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Ethacrynic AcidPMID:19303893
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDEthacrynic Acid results in increased expression of NFE2L2 proteinPMID:20934533
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDEthacrynic Acid results in increased expression of and affects the localization of NFE2L2 protein; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]PMID:26945724 PMID:35724838
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Ethacrynic Acid]PMID:20932822
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