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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:736539 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TGFBR3 mRNA | CTD | PMID:22079256 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA; more ... | CTD | PMID:15878966 | 17beta-estradiol | increases expression | ISO | RGD:736539 | 6480464 | Estradiol results in increased expression of TGFBR3 mRNA | CTD | PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:736539 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TGFBR3 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:736539 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TGFBR3 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:62112 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TGFBR3 mRNA | CTD | PMID:14728982 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62112 | 6480464 | AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TGFBR3 mRNA] | CTD | PMID:14728982 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:62112 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TGFBR3 mRNA | CTD | PMID:20188158 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:62112 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of TGFBR3 mRNA | CTD | PMID:20829426 | 5-fluorouracil | increases expression | ISO | RGD:736539 | 6480464 | Fluorouracil results in increased expression of TGFBR3 mRNA | CTD | PMID:16557594 | all-trans-retinoic acid | decreases expression | ISO | RGD:62112 | 6480464 | Tretinoin results in decreased expression of TGFBR3 mRNA | CTD | PMID:15389595 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of TGFBR3 mRNA | CTD | PMID:16483693 | benzene | increases expression | ISO | RGD:736539 | 6480464 | Benzene results in increased expression of TGFBR3 mRNA | CTD | PMID:20036648 | benzo[a]pyrene | decreases expression | ISO | RGD:736539 | 6480464 | Benzo(a)pyrene results in decreased expression of TGFBR3 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:736539 | 6480464 | Benzo(a)pyrene results in increased expression of TGFBR3 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | increases expression | ISO | RGD:62112 | 6480464 | Benzo(a)pyrene results in increased expression of TGFBR3 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:62112 | 6480464 | Benzo(a)pyrene results in decreased expression of TGFBR3 mRNA | CTD | PMID:22228805 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of TGFBR3 promoter | CTD | PMID:22457795 | choline | multiple interactions | ISO | RGD:62112 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFBR3 gene | CTD | PMID:20938992 | cisplatin | decreases expression | ISO | RGD:62112 | 6480464 | Cisplatin results in decreased expression of TGFBR3 mRNA | CTD | PMID:21151649 | copper(2+) sulfate | decreases expression | ISO | RGD:736539 | 6480464 | Copper Sulfate results in decreased expression of TGFBR3 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:736539 | 6480464 | Cyclosporine results in decreased expression of TGFBR3 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:736539 | 6480464 | Cyclosporine results in decreased expression of TGFBR3 mRNA | CTD | PMID:20106945 PMID:21632981 | cytarabine | decreases expression | ISO | RGD:736539 | 6480464 | Cytarabine results in decreased expression of TGFBR3 mRNA | CTD | PMID:21198554 | diazepam | decreases expression | ISO | RGD:736539 | 6480464 | Diazepam results in decreased expression of TGFBR3 mRNA | CTD | PMID:19114084 | elemental selenium | decreases expression | ISO | RGD:736539 | 6480464 | Selenium results in decreased expression of TGFBR3 mRNA | CTD | PMID:19244175 | folic acid | multiple interactions | ISO | RGD:62112 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFBR3 gene | CTD | PMID:20938992 | fulvestrant | multiple interactions | EXP | | 6480464 | fulvestrant inhibits the reaction [[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA] | CTD | PMID:15878966 | indomethacin | increases expression | EXP | | 6480464 | Indomethacin results in increased expression of TGFBR3 mRNA | CTD | PMID:17440234 | L-methionine | multiple interactions | ISO | RGD:62112 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGFBR3 gene | CTD | PMID:20938992 | lead diacetate | increases expression | EXP | | 6480464 | lead acetate results in increased expression of TGFBR3 mRNA | CTD | PMID:22641619 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR3 mRNA | CTD | PMID:8565130 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR3 protein; more ... | CTD | PMID:8001232 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TGFBR3 mRNA | CTD | PMID:18164116 | phenobarbital | multiple interactions | ISO | RGD:62112 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TGFBR3 mRNA] | CTD | PMID:19482888 | phenobarbital | multiple interactions | EXP | | 6480464 | [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TGFBR3 mRNA | CTD | PMID:8565130 | phenobarbital | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of TGFBR3 mRNA; more ... | CTD | PMID:8001232 | phenobarbital | decreases expression | ISO | RGD:62112 | 6480464 | Phenobarbital results in decreased expression of TGFBR3 mRNA | CTD | PMID:19482888 | selenium atom | decreases expression | ISO | RGD:736539 | 6480464 | Selenium results in decreased expression of TGFBR3 mRNA | CTD | PMID:19244175 | sirolimus | increases expression | ISO | RGD:62112 | 6480464 | Sirolimus results in increased expression of TGFBR3 mRNA | CTD | PMID:11355896 | styrene | affects expression | ISO | RGD:736539 | 6480464 | Styrene affects the expression of TGFBR3 mRNA; more ... | CTD | PMID:16705669 | styrene oxide | affects expression | ISO | RGD:736539 | 6480464 | styrene oxide affects the expression of TGFBR3 protein; more ... | CTD | PMID:16705669 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TGFBR3 mRNA | CTD | PMID:17056239 PMID:16644059 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TGFBR3 mRNA | CTD | PMID:16644059 PMID:17056239 | tetrachloromethane | affects expression | ISO | RGD:62112 | 6480464 | Carbon Tetrachloride affects the expression of TGFBR3 mRNA | CTD | PMID:17484886 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of TGFBR3 mRNA | CTD | PMID:17621560 | trimellitic anhydride | decreases expression | ISO | RGD:62112 | 6480464 | trimellitic anhydride results in decreased expression of TGFBR3 mRNA | CTD | PMID:19042947 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| Pathway Interaction Database | TGF-beta receptor signaling (PID:200227) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| Pathway Interaction Database | TGF-beta receptor signaling (PID:200227) |
References - curated| 1. |
Andres JL, etal., J Biol Chem. 1991 Dec 5;266(34):23282-7. |
| 2. |
Andres JL, etal., J Biol Chem. 1992 Mar 25;267(9):5927-30. |
| 3. |
Andres JL, etal., J Cell Biol. 1989 Dec;109(6 Pt 1):3137-45. |
| 4. |
Boyer AS and Runyan RB, Dev Dyn. 2001 Aug;221(4):454-9. |
| 5. |
Casagrandi D, etal., Mol Hum Reprod. 2003 Apr;9(4):199-203. |
| 6. |
Chapman SC and Woodruff TK, Endocrinology 2003 Dec;144(12):5640-9. Epub 2003 Sep 18. |
| 7. |
Chapman SC, etal., Mol Cell Endocrinol. 2002 Oct 31;196(1-2):79-93. |
| 8. |
Copland JA, etal., Oncogene. 2003 Sep 11;22(39):8053-62. |
| 9. |
Farnworth PG, etal., J Endocrinol. 2006 Mar;188(3):451-65. |
| 10. |
Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84. |
| 11. |
Gao J, etal., J Periodontal Res. 1999 Feb;34(2):113-22. |
| 12. |
GOA data from the GO Consortium |
| 13. |
Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14. |
| 14. |
Lewis KA, etal., Nature. 2000 Mar 23;404(6776):411-4. |
| 15. |
Lopez-Casillas F, etal., Cell 1991 Nov 15;67(4):785-95. |
| 16. |
Lopez-Casillas F, etal., J Cell Biol. 1994 Feb;124(4):557-68. |
| 17. |
MacConell LA, etal., Endocrinology 2002 Mar;143(3):1066-75. |
| 18. |
MGD data from the GO Consortium |
| 19. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 20. |
Nishikawa Y, etal., J Cell Physiol. 1998 Sep;176(3):612-23. |
| 21. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 22. |
RGD automated data pipeline |
| 23. |
RGD automated import pipeline for gene-chemical interactions |
| 24. |
Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700. |
| 25. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 26. |
Vicencio AG, etal., J Appl Physiol 2002 Sep;93(3):1123-30. |
| 27. |
Wang XF, etal., Cell 1991 Nov 15;67(4):797-805. |
| 28. |
Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7. |
References - uncuratedRGD Disease Portals| Tgfbr3 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Tgfbr3 (Rattus norvegicus) |
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| TGFBR3 (Homo sapiens) |
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| Tgfbr3 (Mus musculus) |
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Position Markers| D14Rat69 |
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| D14Wox30 |
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| RH143675 |
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| AU049133 |
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| AU049415 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_017256 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06077243 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06077244 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06077245 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077761 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077762 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077763 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077764 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077765 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077766 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077767 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474079 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M77809 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M80784 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_017256 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058952 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058952 | (Get FASTA) |
| GenBank Protein | AAA40813 | (Get FASTA) |
| AAA42236 | (Get FASTA) | |
| EDL83965 | (Get FASTA) | |
| P26342 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002093 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000002867 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000002867 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 29610 | ENTREZGENE |
| Germonline | ENSRNOG00000002093 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2436 | ENTREZGENE |
| InterPro | Endoglin/CD105 | UniProtKB/Swiss-Prot |
| Endoglin/CD105_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00192559 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:29610 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Zona_pellucida | UniProtKB/Swiss-Prot |
| PRINTS | ZPELLUCIDA | UniProtKB/Swiss-Prot |
| PROSITE | ZP_1 | UniProtKB/Swiss-Prot |
| ZP_2 | UniProtKB/Swiss-Prot | |
| SMART | SM00241 | UniProtKB/Swiss-Prot |
| TIGR | TC208061 | |
| UniGene | Rn.9953 | ENTREZGENE |
| UniProt | TGBR3_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-01-20 | Tgfbr3 | transforming growth factor, beta receptor 3 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-06-10 | Tgfbr3 | transforming growth factor, beta receptor 3 | Name updated | 1489 | PROVISIONAL | ||
| 2001-05-08 | Tgfr3 | transforming growth factor, beta receptor III | Typographical error in gene symbol | 434 | WITHDRAWN | ||
| 2001-05-08 | Tgfbr3 | transforming growth factor, beta receptor III | Original symbol typographical error corrected | 434 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | integral cellular membrane protein | 61766 |
| gene_expression | expressed in reproductive tissues and cells, brain and pituitary gland | 730228 |
| gene_physical_interaction | binds inhibin A and TGF beta | 730228 |
| gene_physical_interaction | specifically binds TGF beta 1 | 729942 |
| gene_process | may modulate effects of inhibin and TGF beta in reproductive tissues | 730228 |
| gene_process | may regulate TGF beta II receptor function or expression | 729942 |
| gene_process | may regulate follicle-stimulating hormone (FSH) release from pituitary by regulation of inhibin | 1299110 |
| gene_protein | 853 amino acid core protein; expressed as a membrane-anchored proteoglycan | 61766 |
| gene_regulation | expression levels in lung are downregulated following hypoxia | 727411 |
| More on Tgfbr3 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61821 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.