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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | decreases expression | ISO | RGD:1321618 | 6480464 | epigallocatechin gallate results in decreased expression of ITGAV mRNA | CTD | PMID:16084531 | (R)-adrenaline | increases expression | ISO | RGD:1321618 | 6480464 | Epinephrine results in increased expression of ITGAV mRNA | CTD | PMID:12729923 | (S)-nicotine | increases expression | ISO | RGD:1617623 | 6480464 | Nicotine results in increased expression of ITGAV mRNA | CTD | PMID:17997037 | 1-chloro-2,4-dinitrobenzene | affects expression | ISO | RGD:1617623 | 6480464 | Dinitrochlorobenzene affects the expression of ITGAV mRNA | CTD | PMID:22302311 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ITGAV mRNA | CTD | PMID:21346803 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:1617623 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of ITGAV mRNA | CTD | PMID:20829426 | 5-fluorouracil | affects response to substance | ISO | RGD:1321618 | 6480464 | ITGAV protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | aflatoxin B1 | affects expression | ISO | RGD:1321618 | 6480464 | Aflatoxin B1 affects the expression of ITGAV protein | CTD | PMID:20106945 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1321618 | 6480464 | Tretinoin results in increased cleavage of [ITGAV protein binds to ITGB1 protein] | CTD | PMID:11369141 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1321618 | 6480464 | Tretinoin results in increased expression of [ITGAV protein binds to ITGB1 protein] | CTD | PMID:11718225 | alpha-hexylcinnamaldehyde | affects expression | ISO | RGD:1617623 | 6480464 | hexyl cinnamic aldehyde affects the expression of ITGAV mRNA | CTD | PMID:22302311 | arsenite(3-) | decreases expression | ISO | RGD:1617623 | 6480464 | arsenite results in decreased expression of ITGAV mRNA | CTD | PMID:18191166 | benzo[a]pyrene | multiple interactions | ISO | RGD:1321618 | 6480464 | Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased expression of ITGAV protein]; more ... | CTD | PMID:20876236 | choline | multiple interactions | ISO | RGD:1617623 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITGAV gene; more ... | CTD | PMID:20938992 | cisplatin | decreases response to substance | ISO | RGD:1321618 | 6480464 | ITGAV results in decreased susceptibility to Cisplatin | CTD | PMID:21795690 | cisplatin | multiple interactions | EXP | | 6480464 | ITGAV affects the reaction [Cisplatin affects the localization of BAX] | CTD | PMID:21795690 | copper(2+) sulfate | increases expression | ISO | RGD:1321618 | 6480464 | Copper Sulfate results in increased expression of ITGAV mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:1321618 | 6480464 | Cyclosporine results in increased expression of ITGAV mRNA | CTD | PMID:20106945 | dasatinib (anhydrous) | increases expression | ISO | RGD:1321618 | 6480464 | dasatinib results in increased expression of ITGAV mRNA | CTD | PMID:20579391 | dibutyl phthalate | increases expression | ISO | RGD:1617623 | 6480464 | Dibutyl Phthalate results in increased expression of ITGAV mRNA | CTD | PMID:21266533 | folic acid | multiple interactions | ISO | RGD:1617623 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ITGAV gene; more ... | CTD | PMID:20938992 | gefitinib | multiple interactions | ISO | RGD:1617623 | 6480464 | gefitinib inhibits the reaction [TNF protein results in increased expression of ITGAV mRNA] | CTD | PMID:15841081 | genistein | decreases expression | ISO | RGD:1321618 | 6480464 | Genistein results in decreased expression of ITGAV protein | CTD | PMID:20884965 | genistein | multiple interactions | ISO | RGD:1321618 | 6480464 | ESR2 promotes the reaction [Genistein results in decreased expression of ITGAV protein] | CTD | PMID:20884965 | hydrogen peroxide | decreases expression | ISO | RGD:1321618 | 6480464 | Hydrogen Peroxide results in decreased expression of ITGAV mRNA | CTD | PMID:12419474 | isotretinoin | increases expression | ISO | RGD:1321618 | 6480464 | Isotretinoin results in increased expression of ITGAV mRNA | CTD | PMID:20436886 | L-methionine | multiple interactions | ISO | RGD:1617623 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of ITGAV; more ... | CTD | PMID:20938992 | LY294002 | multiple interactions | ISO | RGD:1321618 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] | CTD | PMID:15213856 | manganese(II) chloride | multiple interactions | ISO | RGD:1321618 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; more ... | CTD | PMID:15213856 | methyl salicylate | affects expression | ISO | RGD:1617623 | 6480464 | methyl salicylate affects the expression of ITGAV mRNA | CTD | PMID:22302311 | N-acetyl-L-cysteine | decreases expression | ISO | RGD:1321618 | 6480464 | Acetylcysteine results in decreased expression of ITGAV mRNA | CTD | PMID:16084531 | nonanoic acid | affects expression | ISO | RGD:1617623 | 6480464 | pelargonic acid affects the expression of ITGAV mRNA | CTD | PMID:22302311 | paracetamol | decreases expression | ISO | RGD:1321618 | 6480464 | Acetaminophen results in decreased expression of ITGAV mRNA | CTD | PMID:21420995 | phthalaldehyde | affects expression | ISO | RGD:1617623 | 6480464 | o-Phthalaldehyde affects the expression of ITGAV mRNA | CTD | PMID:22302311 | pioglitazone | multiple interactions | ISO | RGD:1321618 | 6480464 | pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ITGAV mRNA] | CTD | PMID:20847119 | pirinixic acid | multiple interactions | ISO | RGD:1617623 | 6480464 | NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ITGAV mRNA] | CTD | PMID:17950772 | pirinixic acid | decreases expression | ISO | RGD:1617623 | 6480464 | pirinixic acid results in decreased expression of ITGAV mRNA | CTD | PMID:17950772 | quercetin | decreases expression | ISO | RGD:1321618 | 6480464 | Quercetin results in decreased expression of ITGAV mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:1321618 | 6480464 | resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of GRB2 protein]; more ... | CTD | PMID:21467134 | rosiglitazone | multiple interactions | ISO | RGD:1321618 | 6480464 | [rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ITGAV mRNA; more ... | CTD | PMID:20847119 | sirolimus | decreases expression | ISO | RGD:1617623 | 6480464 | Sirolimus results in decreased expression of ITGAV protein; more ... | CTD | PMID:19922502 | succimer | multiple interactions | ISO | RGD:1617623 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of ITGAV mRNA | CTD | PMID:21641980 | tert-butyl hydroperoxide | multiple interactions | ISO | RGD:1321618 | 6480464 | pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ITGAV mRNA]; more ... | CTD | PMID:20847119 | tert-butyl hydroperoxide | increases expression | ISO | RGD:1321618 | 6480464 | tert-Butylhydroperoxide results in increased expression of ITGAV mRNA | CTD | PMID:20847119 | testosterone enanthate | affects expression | ISO | RGD:1321618 | 6480464 | testosterone enanthate affects the expression of ITGAV mRNA | CTD | PMID:17440010 | tetrachloromethane | affects expression | ISO | RGD:1617623 | 6480464 | Carbon Tetrachloride affects the expression of ITGAV mRNA | CTD | PMID:17484886 | trans-resveratrol | multiple interactions | ISO | RGD:1321618 | 6480464 | resveratrol promotes the reaction [[ITGAV protein binds to ITGB3 protein] which affects the localization of GRB2 protein]; more ... | CTD | PMID:21467134 | trimellitic anhydride | affects expression | ISO | RGD:1617623 | 6480464 | trimellitic anhydride affects the expression of ITGAV mRNA | CTD | PMID:22302311 | troglitazone | multiple interactions | ISO | RGD:1321618 | 6480464 | troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ITGAV mRNA] | CTD | PMID:20847119 | wortmannin | multiple interactions | ISO | RGD:1321618 | 6480464 | wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] | CTD | PMID:15213856 | zinc atom | decreases expression | ISO | RGD:1321618 | 6480464 | Zinc results in decreased expression of ITGAV mRNA | CTD | PMID:19071009 | zinc(0) | decreases expression | ISO | RGD:1321618 | 6480464 | Zinc results in decreased expression of ITGAV mRNA | CTD | PMID:19071009 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Cell adhesion molecules (CAMs) | |
| Dilated cardiomyopathy | |
| ECM-receptor interaction | |
| Focal adhesion | |
| Hypertrophic cardiomyopathy (HCM) | |
| Pathways in cancer | |
| Phagosome | |
| PI3K-Akt signaling pathway | |
| Regulation of actin cytoskeleton | |
| Small cell lung cancer | |
| Pathway Interaction Database | Arf6 trafficking events (PID:200057) |
| Beta1 integrin cell surface interactions (PID:200016) | |
| Beta3 integrin cell surface interactions (PID:200043) | |
| Beta5 beta6 beta7 and beta8 integrin cell surface interactions (PID:200169) | |
| CXCR4-mediated signaling events (PID:200099) | |
| Integrin family cell surface interactions (PID:200039) | |
| Integrins in angiogenesis (PID:200128) | |
| Nectin adhesion pathway (PID:200065) | |
| Osteopontin-mediated events (PID:200053) | |
| PDGFR-alpha signaling pathway (PID:200162) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| S1P1 pathway (PID:200085) | |
| S1P3 pathway (PID:200046) | |
| Signaling events mediated by focal adhesion kinase (PID:200224) | |
| Signaling events mediated by VEGFR1 and VEGFR2 (PID:200188) | |
| Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling (PID:200139) | |
References - curated| 1. |
Arteaga RB, etal., Am J Cardiol. 2006 Jul 1;98(1):70-4. Epub 2006 May 4. |
| 2. |
Baron W, etal., EMBO J. 2002 Apr 15;21(8):1957-66. |
| 3. |
Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27. |
| 4. |
Campbell S, etal., Endocrinology. 2003 Apr;144(4):1486-95. |
| 5. |
Chang Y and Finnemann SC, J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7. |
| 6. |
Chettab K, etal., Thromb Haemost. 2002 Jan;87(1):141-8. |
| 7. |
Choi ET, etal., Circulation. 2004 Mar 30;109(12):1564-9. Epub 2004 Mar 8. |
| 8. |
Choke E, etal., Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2077-82. Epub 2006 Jun 29. |
| 9. |
Dufourcq P, etal., Cardiovasc Res. 2002 Mar;53(4):952-62. |
| 10. |
Frontczak-Baniewicz M and Walski M, Acta Neurobiol Exp (Wars). 2003;63(2):65-75. |
| 11. |
GOA data from the GO Consortium |
| 12. |
Heerkens EH, etal., Hypertension. 2006 Feb;47(2):281-7. Epub 2005 Dec 27. |
| 13. |
Hynes RO Cell 2002 Sep 20;110(6):673-87. |
| 14. |
Klotz O, etal., Graefes Arch Clin Exp Ophthalmol. 2000 Jan;238(1):88-93. |
| 15. |
Lee KH, etal., J Nucl Med. 2005 Mar;46(3):472-8. |
| 16. |
Leong-Poi H, etal., Circulation. 2005 Jun 21;111(24):3248-54. Epub 2005 Jun 13. |
| 17. |
Miyauchi A, etal., J Bone Miner Metab. 2006;24(6):498-504. |
| 18. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 19. |
RGD automated data pipeline |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9. |
| 22. |
Takada Y, etal., Genome Biol. 2007;8(5):215. |
| 23. |
Takagi H, etal., Jpn J Ophthalmol. 2002 May-Jun;46(3):270-8. |
| 24. |
Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3. |
| 25. |
Wilkinson-Berka JL, etal., Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5. |
| 26. |
Yamani MH, etal., Circulation. 2002 Apr 23;105(16):1955-61. |
| 27. |
Yamani MH, etal., J Heart Lung Transplant. 2005 Aug;24(8):1014-8. |
| 28. |
Yasukawa T, etal., Curr Eye Res. 2004 May;28(5):359-66. |
References - uncurated| PubMed | 15044441 |
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| 15695822 | |
| 16135088 | |
| 16489109 | |
| 17442458 | |
| 18221819 | |
| 18256073 | |
| 18538673 | |
| 19122172 | |
| 19359426 | |
| 19723805 | |
| 19734584 | |
| 19739252 | |
| 20463011 | |
| 20580365 | |
| 21502139 | |
| 21792920 | |
| 22262456 | |
| 22885106 | |
| 22915765 | |
| 23161541 |
RGD Disease Portals| Itgav has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Itgav (Rattus norvegicus) |
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| ITGAV (Homo sapiens) |
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| Itgav (Mus musculus) |
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Position Markers| D3Got143 |
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| RH140315 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | XM_003749496 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_003753778 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06024486 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06024487 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024488 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024489 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024490 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024491 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06024492 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023097 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023098 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023099 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01023100 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BN000401 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473949 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001106549 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003749496 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_003749544 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003753778 |
| RefSeq Status: | |
| Type: | CODING |
| Protein Acc Id: | XP_003753826 |
| Position: | No map positions available. |
Protein Sequences| Protein RefSeqs | XP_003749544 | (Get FASTA) |
| XP_003753826 | (Get FASTA) | |
| GenBank Protein | EDL79295 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Entrez Gene | 296456 | ENTREZGENE |
| HomoloGene Group ID | 20510 | ENTREZGENE |
| KEGG Report | rno:296456 | ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2009-12-15 | Itgav | integrin, alpha V | Itgav | integrin alpha V | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Itgav | integrin alpha V | Itgav_predicted | integrin alpha V (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2006-03-30 | Itgav_predicted | integrin alpha V (predicted) | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted) | Name updated | 10779 | APPROVED | |
| 2005-01-12 | Itgav_predicted | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Itgav | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1310613 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.