Araf (A-Raf proto-oncogene, serine/threonine kinase)

Gene: Araf (A-Raf proto-oncogene, serine/threonine kinase) Rattus norvegicus

Analyze

Symbol:

Araf

Name:

A-Raf proto-oncogene, serine/threonine kinase

RGD ID:

2148

Description:

Enables MAP kinase kinase kinase activity. Predicted to be involved in several processes, including MAPK cascade; regulation of TOR signaling; and regulation of protein metabolic process. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

A-Raf proto-oncogene serine/threonine-protein kinase; Araf1; proto-oncogene A-Raf; proto-oncogene A-Raf-1; Raf related protein; Ras-binding protein; serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog; v-raf murine sarcoma 3611 viral oncogene homolog 1; v-raf oncogene homolog 1 (murine sarcoma 3611 virus)

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	3,780,932 - 3,845,919 (-)	NCBI		GRCr8
mRatBN7.2	X	1,227,392 - 1,292,356 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,227,392 - 1,239,073 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	1,255,531 - 1,267,209 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,731,222 - 4,742,902 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	1,052,386 - 1,064,071 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,369,534 - 1,391,603 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,379,194 - 1,390,873 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	2,194,385 - 2,206,064 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	12,556,904 - 12,568,583 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	12,562,471 - 12,572,791 (-)	NCBI
Celera	X	1,795,227 - 1,806,868 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Breast Neoplasms (ISO)

congenital disorder of glycosylation type IIm (ISO)

genetic disease (ISO)

high grade glioma (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

papillary renal cell carcinoma (ISO)

skin melanoma (ISO)

Sporadic Papillary Renal Cell Carcinoma (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-nitrophenol (ISO)

4-vinylcyclohexene dioxide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

auramine O (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorohydrocarbon (EXP)

coumarin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dexamethasone (ISO)

diazinon (EXP,ISO)

diclofenac (ISO)

dicrotophos (ISO)

dieldrin (EXP)

elemental selenium (ISO)

ethanol (ISO)

fenbendazole (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furan (EXP)

gentamycin (EXP)

indometacin (ISO)

irinotecan (ISO)

lead(0) (ISO)

mifepristone (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

nickel dichloride (EXP)

niclosamide (ISO)

ouabain (ISO)

ozone (ISO)

paracetamol (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

tetrachloromethane (EXP)

thapsigargin (EXP)

thioacetamide (EXP)

triptonide (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (TAS)

MAPK cascade (IBA)

negative regulation of apoptotic process (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

protein phosphorylation (IDA,TAS)

Ras protein signal transduction (IEA)

regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO,ISS)

regulation of TOR signaling (ISO,ISS)

signal transduction (IEA)

Cellular Component

cytosol (IBA,TAS)

mitochondrion (IBA,ISO)

Molecular Function

ATP binding (IEA)

MAP kinase kinase kinase activity (IBA,IDA,TAS)

metal ion binding (IEA)

protein binding (ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

the extracellular signal-regulated Raf/Mek/Erk signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Hepatic epidermal growth factor-regulated mitogen-activated protein kinase kinase kinase activity in the rat: lack of identity with known forms of raf and MEKK.	Gruppuso PA and Boylan JM, FEBS Lett. 2000 Jan 21;466(1):200-4.
3.	IGFBP2 expression predicts IDH-mutant glioma patient survival.	Huang LE, etal., Oncotarget. 2017 Jan 3;8(1):191-202. doi: 10.18632/oncotarget.13329.
4.	The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf.	Ishikawa F, etal., Oncogene Res 1987 Aug;1(3):243-53.
5.	Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart.	Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	MEK1/2 dual-specificity protein kinases: Structure and regulation.	Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
12.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13.	Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition.	Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.

Additional References at PubMed

PMID:3491291	PMID:8889548	PMID:9679960	PMID:12060780	PMID:12477932	PMID:12931191	PMID:17380122	PMID:17535970	PMID:19667065	PMID:22609986

Genomics

Comparative Map Data

Araf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	3,780,932 - 3,845,919 (-)	NCBI		GRCr8
mRatBN7.2	X	1,227,392 - 1,292,356 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,227,392 - 1,239,073 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	1,255,531 - 1,267,209 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,731,222 - 4,742,902 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	1,052,386 - 1,064,071 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,369,534 - 1,391,603 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,379,194 - 1,390,873 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	2,194,385 - 2,206,064 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	12,556,904 - 12,568,583 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	12,562,471 - 12,572,791 (-)	NCBI
Celera	X	1,795,227 - 1,806,868 (-)	NCBI		Celera
Cytogenetic Map	X	q11	NCBI

ARAF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	47,561,205 - 47,571,908 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	47,561,205 - 47,571,908 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	47,420,604 - 47,431,307 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	47,305,522 - 47,316,264 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	47,176,760 - 47,187,553	NCBI
Celera	X	51,615,774 - 51,626,577 (+)	NCBI		Celera
Cytogenetic Map	X	p11.3	NCBI
HuRef	X	45,132,731 - 45,143,540 (+)	NCBI		HuRef
CHM1_1	X	47,451,606 - 47,462,422 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	46,971,095 - 46,981,798 (+)	NCBI		T2T-CHM13v2.0

Araf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	20,663,946 - 20,726,760 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	20,664,053 - 20,726,758 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	20,797,707 - 20,860,521 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	20,797,814 - 20,860,519 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	20,425,669 - 20,437,647 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	20,005,557 - 20,017,477 (+)	NCBI		MGSCv36	mm8
Celera	X	18,979,682 - 18,991,660 (+)	NCBI		Celera
Cytogenetic Map	X	A1.3	NCBI
cM Map	X	16.3	NCBI

Araf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955516	521,479 - 533,212 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955516	521,479 - 532,980 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARAF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	49,187,387 - 49,198,328 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	49,190,579 - 49,201,699 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	39,997,026 - 40,007,783 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	47,893,153 - 47,904,643 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	47,893,153 - 47,904,643 (+)	Ensembl	panpan1.1		panPan2

ARAF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	41,180,082 - 41,191,579 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	41,180,250 - 41,191,310 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	15,555,116 - 15,566,605 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	41,314,276 - 41,325,765 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	41,314,438 - 41,325,764 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	41,301,898 - 41,313,372 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	41,290,159 - 41,301,648 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,382,798 - 41,394,286 (+)	NCBI		UU_Cfam_GSD_1.0

Araf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	33,482,616 - 33,494,254 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	13,323,355 - 13,335,224 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	13,323,365 - 13,335,003 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARAF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	42,078,206 - 42,090,250 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	42,078,202 - 42,090,250 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	47,388,650 - 47,400,702 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	X	p13	NCBI

LOC103231895
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,738,406 - 44,748,996 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,740,181 - 44,748,550 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666566	38,210 - 47,870 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Araf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624978	100,505 - 110,646 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624978	99,605 - 110,645 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Araf
131 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	518
Count of miRNA genes:	273
Interacting mature miRNAs:	325
Transcripts:	ENSRNOT00000039911
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat

Markers in Region

RH131306

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	1,235,565 - 1,235,767 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	1,387,366 - 1,387,567	NCBI	Rnor6.0
Rnor_5.0	X	2,202,557 - 2,202,758	UniSTS	Rnor5.0
RGSC_v3.4	X	12,565,076 - 12,565,277	UniSTS	RGSC3.4
Celera	X	1,803,361 - 1,803,562	UniSTS
RH 3.4 Map	18	532.0	UniSTS
Cytogenetic Map	X	q11.1	UniSTS

Araf

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	1,233,634 - 1,234,075 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	1,385,435 - 1,385,875	NCBI	Rnor6.0
Rnor_5.0	X	2,200,626 - 2,201,066	UniSTS	Rnor5.0
RGSC_v3.4	X	12,563,145 - 12,563,585	UniSTS	RGSC3.4
Celera	X	1,801,430 - 1,801,870	UniSTS
Cytogenetic Map	X	q11.1	UniSTS

AW495444

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	1,235,675 - 1,235,783 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	1,387,476 - 1,387,583	NCBI	Rnor6.0
Rnor_5.0	X	2,202,667 - 2,202,774	UniSTS	Rnor5.0
RGSC_v3.4	X	12,565,186 - 12,565,293	UniSTS	RGSC3.4
Celera	X	1,803,471 - 1,803,578	UniSTS
Cytogenetic Map	X	q11.1	UniSTS

RH141572

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	1,227,619 - 1,227,813 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	1,379,422 - 1,379,615	NCBI	Rnor6.0
Rnor_5.0	X	2,194,613 - 2,194,806	UniSTS	Rnor5.0
RGSC_v3.4	X	12,557,132 - 12,557,325	UniSTS	RGSC3.4
Celera	X	1,795,455 - 1,795,648	UniSTS
Cytogenetic Map	X	q11.1	UniSTS

UniSTS:224356

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	1,227,192 - 1,227,306 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	1,378,995 - 1,379,108	NCBI	Rnor6.0
Rnor_5.0	X	2,194,186 - 2,194,299	UniSTS	Rnor5.0
RGSC_v3.4	X	12,556,705 - 12,556,818	UniSTS	RGSC3.4
Celera	X	1,795,028 - 1,795,141	UniSTS
Cytogenetic Map	X	q11.1	UniSTS
Cytogenetic Map	X	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	36	11	8
Low											5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB158253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI060060	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI712552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC060568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG668593	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO572305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV728203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X06942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000039911 ⟹ ENSRNOP00000048890

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	1,227,392 - 1,239,073 (-)	Ensembl
Rnor_6.0 Ensembl	X	1,379,194 - 1,390,873 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097792 ⟹ ENSRNOP00000082142

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	1,234,872 - 1,239,071 (-)	Ensembl

RefSeq Acc Id:

NM_001033663 ⟹ NP_001028835

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	3,788,396 - 3,792,611 (-)	NCBI
mRatBN7.2	X	1,234,858 - 1,239,073 (-)	NCBI
Rnor_6.0	X	1,386,658 - 1,390,873 (-)	NCBI
Rnor_5.0	X	2,194,385 - 2,206,064 (-)	NCBI
RGSC_v3.4	X	12,556,904 - 12,568,583 (-)	RGD
Celera	X	1,802,653 - 1,806,868 (-)	NCBI

Sequence:

show sequence

AAGAAGACAAGCCCAAGATGGAGGCGGTGGTGGCGGTAGCGGTGTGACAGGAGGCCTATGGCAC
CTGCCCAGTCCTACCTCAGCCCATCTTGAAAAAATCCTTAGACAACATGGAACCACCACGAGGC
CCTCCTGCTAGTGGGGCTGAGCCATCTCGGGCAGTTGGCACTGTCAAAGTGTACCTGCCTAACA
AGCAACGCACAGTGGTGACTGTCCGGGATGGCATGAGTGTCTATGACTCTTTGGACAAGGCCCT
CAAGGTGCGGGGTCTCAATCAGGACTGCTGTGTGGTCTACAGACTCATCAAAGGAAGAAAGACA
GTCACTGCCTGGGACACAGCCATTGCACCTCTGGATGGCGAGGAGCTCATTGTGGAGGTCCTGG
AAGATGTGCCACTGACCATGCACAATTTTGTACGGAAGACATTCTTCAGTTTGGCCTTCTGTGA
CTTCTGCCTTAAGTTTCTGTTCCACGGCTTTCGCTGCCAAACCTGTGGCTACAAGTTCCACCAG
CATTGTTCCTCCAAGGTCCCCACGGTCTGCGTTGACATGAGTACCAACCGCCGACAGTTCTACC
ACAGCATCCAGGATTTGTCTGGAGGCTCCAGGCAGCAGGAGGTTCCCTCAAATCTCTCTGTGAA
TGAGCTGCTAACCCCCCAGGGTCCCAGGTAGGGATGTCGTAGATGAAAGGCCAGGGGCCAGTGA
AAGAAGGATTGGAGGACCCTGACAGATTATAGTTTCGTTTATTTGTTTACGTGATAAATACTAT
TGAGTACCTACAAGTATTGAATAAGGGCATGGGACTGTGGGATCATTGGTAAGGCACCTGGTCA
CTCCAGGTTTCATTCTTTTCATCTGGGAAGAGGGGATGAGACTTTTTCATAGTGGGTTCTGAAG
AGGATTAAGAGTTGAGATATTTGCAATGCTTAAAACAAGATCTGATGTAGAGTGAATAACGATT
CATATTAATTACAAGTGTATATATAAAAACGTCTAGTTTGTTCATTTCTTCCAGTATAACCACA
CCCCAGTCTTTTCTCTTTGAAATAAATGTTGCTGTATCAGAAAGAACTTTTATTTCACTTATGT
TGGATATGATAGCATATAGTTTTACATAATATATAAAAAGTAAGGTTAACGTATTATTATTTGT
AGTTTTGAGTGTATTGTGTTGATTTACCTGTGAATTTAATCTCAGAATGGTGAAAGTAACAGAA
GAATGTTTTTCTGTAAGGTATAATTCATGGGAGGTGGAGGCAAGACGATCAATAGTTCAAGGCT
ACCCTCCACTAAGTAGCAAGTTCAAGGCCAGCCTGGGCTACATGAGACTGTCTTAAAACAGTAA
AAAAGTTTTTTTGTATCGTGATATATGTATAATCTTTATATGTTGTGTGTAATGTGTATTACAT
AATATGATAATATGTGTATTGAAAACGTTGCCATTTTAATATAGGTAATGCTCATTATTATAAA
ATAAATAATATATTTGAAAAATACATGTCATTATGATATGTAATAAAAAGTCATATCTTACCCT
TTCTCC

hide sequence

RefSeq Acc Id:

NM_022532 ⟹ NP_071977

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	3,780,932 - 3,792,611 (-)	NCBI
mRatBN7.2	X	1,227,392 - 1,239,073 (-)	NCBI
Rnor_6.0	X	1,379,194 - 1,390,873 (-)	NCBI
Rnor_5.0	X	2,194,385 - 2,206,064 (-)	NCBI
RGSC_v3.4	X	12,556,904 - 12,568,583 (-)	RGD
Celera	X	1,795,227 - 1,806,868 (-)	RGD

Sequence:

show sequence

AAGAAGACAAGCCCAAGATGGAGGCGGTGGTGGCGGTAGCGGTGTGACAGGAGGCCTATGGCAC
CTGCCCAGTCCTACCTCAGCCCATCTTGAAAAAATCCTTAGACAACATGGAACCACCACGAGGC
CCTCCTGCTAGTGGGGCTGAGCCATCTCGGGCAGTTGGCACTGTCAAAGTGTACCTGCCTAACA
AGCAACGCACAGTGGTGACTGTCCGGGATGGCATGAGTGTCTATGACTCTTTGGACAAGGCCCT
CAAGGTGCGGGGTCTCAATCAGGACTGCTGTGTGGTCTACAGACTCATCAAAGGAAGAAAGACA
GTCACTGCCTGGGACACAGCCATTGCACCTCTGGATGGCGAGGAGCTCATTGTGGAGGTCCTGG
AAGATGTGCCACTGACCATGCACAATTTTGTACGGAAGACATTCTTCAGTTTGGCCTTCTGTGA
CTTCTGCCTTAAGTTTCTGTTCCACGGCTTTCGCTGCCAAACCTGTGGCTACAAGTTCCACCAG
CATTGTTCCTCCAAGGTCCCCACGGTCTGCGTTGACATGAGTACCAACCGCCGACAGTTCTACC
ACAGCATCCAGGATTTGTCTGGAGGCTCCAGGCAGCAGGAGGTTCCCTCAAATCTCTCTGTGAA
TGAGCTGCTAACCCCCCAGGGTCCCAGTCCCTTTACCCAGCAACGTGACCAGGAGCACTTCTCC
TTCCCTGCCCCTGCCAATCCCCCACTGCAGCGCATCCGCTCCACATCTACTCCTAACGTCCACA
TGGTCAGCACCACAGCTCCCATGGACTCCAGCCTCATGCAGTTTACTGCTCAGAGCTTCAGCAC
CGATGCTGCTGGTAGAGGTGGTGATGGAGCTCCTCGGGGTAGCCCTAGCCCAGCTAGTGTGTCT
TCAGGGAGGAAGTCCCCACATTCCAAGTTACCTGCAGAACAGCGGGAACGGAAGTCCTTGGCAG
ATGAAAAGAAAAAAGTGAAGAACCTGGGGTACCGGGACTCAGGCTATTACTGGGAGGTGCCACC
CAGTGAGGTACAGCTGTTGAAGAGGATCGGGACAGGCTCTTTTGGCACTGTGTTTCGGGGGCGT
TGGCATGGCGATGTAGCTGTGAAAGTGCTCAAGGTGGCCCAACCTACCGCTGAGCAGGCCCAGG
CCTTCAAGAATGAGATGCAGGTGCTCAGGAAGACACGACATGTCAACATTTTGCTGTTTATGGG
TTTCATGACTCGGCCAGGGTTTGCCATCATCACACAGTGGTGTGAGGGTTCCAGCCTCTACCAC
CACCTACATGTGGCTGACACGCGCTTTGACATGGTCCAGCTCATTGATGTGGCCCGGCAGACTG
CCCAGGGCATGGACTACCTCCACGCCAAGAACATCATTCACCGAGACCTAAAGTCCAACAATAT
CTTCCTACATGAGGGGCTCACAGTCAAGATTGGTGACTTCGGCCTGGCCACAGTGAAGACACGA
TGGAGTGGGGCCCAGCCCTTAGAGCAGCCCTCAGGGTCTGTGCTGTGGATGGCAGCTGAGGTGA
TCCGAATGCAGGACCCGAACCCCTACAGCTTCCAGTCGGATGTCTATGCCTATGGTGTTGTGCT
CTATGAGCTTATGACCGGCTCACTGCCCTACAGCCACATTGGCAGCCGTGACCAGATCATCTTT
ATGGTGGGTCGTGGCTATCTGTCTCCGGACCTCAGCAAAATCTTCAGTAATTGCCCCAAAGCCA
TGAGGCGCTTGCTGACTGACTGCCTCAAGTTCCAGCGGGAGGAGCGGCCTCTATTTCCCCAGAT
TCTGGCCACGATCGAGCTGCTGCAGCGGTCACTCCCCAAGATTGAGCGGAGTGCCTCCGAACCC
TCCTTGCACCGTACCCAGGCTGATGAGTTGCCTGCCTGCCTTCTCAGCGCAGCCCGCCTTGTGC
CTTAGACTCCACTCCCAGCCCACTAGGGAGCCATTTTCAGCTTACCATGCCAAGGCACCCCCTT
CCTACCAGCCAATCATTGTTCTGTCTGTGCCCTGATACTGCCTCAGGATTCCCTATCCCACACC
CTGGGAAATTTGGGGGACTCCAAAAACTGAGGTCCCCTGCTTCCTCCATAATTTGGTCTCCTCT
TGGCTTTGGGGATAGTTCTAATTTGGAGAGCTGTTTTACCTCCAATGGCTGGGATTCAGTGCAA
AGATTCCACTCGGAACCTCTTTATAAAGTTTTCGCCTGACATGTCTTCACTGAATTATGGGGTT
CCCAGCACCCCATGCGGATTTGGGAGTTTCCCTTTGTCTCCCCCCACTATTCAAGGACTCTCCT
CTTTACCAAGAAGCACAGAATTCTGCTGGAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039100021 ⟹ XP_038955949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	3,780,932 - 3,845,919 (-)	NCBI
mRatBN7.2	X	1,227,392 - 1,292,356 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001028835	(Get FASTA)	NCBI Sequence Viewer
	NP_071977	(Get FASTA)	NCBI Sequence Viewer
	XP_038955949	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH60568	(Get FASTA)	NCBI Sequence Viewer
	BAE66644	(Get FASTA)	NCBI Sequence Viewer
	CAA30023	(Get FASTA)	NCBI Sequence Viewer
	EDL97710	(Get FASTA)	NCBI Sequence Viewer
	EDL97711	(Get FASTA)	NCBI Sequence Viewer
	EDL97712	(Get FASTA)	NCBI Sequence Viewer
	EDL97713	(Get FASTA)	NCBI Sequence Viewer
	EDL97714	(Get FASTA)	NCBI Sequence Viewer
	EDL97715	(Get FASTA)	NCBI Sequence Viewer
	EDL97716	(Get FASTA)	NCBI Sequence Viewer
	EDL97717	(Get FASTA)	NCBI Sequence Viewer
	EDL97718	(Get FASTA)	NCBI Sequence Viewer
	EDL97719	(Get FASTA)	NCBI Sequence Viewer
	EDL97720	(Get FASTA)	NCBI Sequence Viewer
	EDL97721	(Get FASTA)	NCBI Sequence Viewer
	EDL97722	(Get FASTA)	NCBI Sequence Viewer
	EDL97723	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048890
	ENSRNOP00000048890.5
	ENSRNOP00000082142
	ENSRNOP00000082142.1
GenBank Protein	P14056	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071977 ⟸ NM_022532
- Peptide Label:	isoform 1
- UniProtKB:	P14056 (UniProtKB/Swiss-Prot), A6JZR3 (UniProtKB/TrEMBL), A6JZR6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRL IKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTC GYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELLTPQGPSPFTQQR DQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFSTDAAGRGGDGAPRGSP SPASVSSGRKSPHSKLPAEQRERKSLADEKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFG TVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCE GSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGL ATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGS RDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIELLQRSLPKIE RSASEPSLHRTQADELPACLLSAARLVP hide sequence

RefSeq Acc Id:	NP_001028835 ⟸ NM_001033663
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I5ZXA9 (UniProtKB/TrEMBL), A6JZR7 (UniProtKB/TrEMBL), A6JZR9 (UniProtKB/TrEMBL), A6JZS1 (UniProtKB/TrEMBL), Q6P9W2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPPRGPPASGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRL IKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTC GYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEVPSNLSVNELLTPQGPR hide sequence

RefSeq Acc Id:

ENSRNOP00000048890 ⟸ ENSRNOT00000039911

RefSeq Acc Id:	XP_038955949 ⟸ XM_039100021
- Peptide Label:	isoform X1
- UniProtKB:	A6JZR2 (UniProtKB/TrEMBL), A6JZR3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000082142 ⟸ ENSRNOT00000097792

Protein Domains

Phorbol-ester/DAG-type Protein kinase RBD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P14056-F1-model_v2	AlphaFold	P14056	1-604	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701692

Promoter ID:

EPDNEW_R12216

Type:

multiple initiation site

Name:

Araf_1

Description:

A-Raf proto-oncogene, serine/threonine kinase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	1,390,865 - 1,390,925	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2148	AgrOrtholog
BioCyc Gene	G2FUF-3198	BioCyc
Ensembl Genes	ENSRNOG00000010838	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039911	ENTREZGENE
	ENSRNOT00000039911.4	UniProtKB/Swiss-Prot
	ENSRNOT00000097792	ENTREZGENE
	ENSRNOT00000097792.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.60.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7930982	IMAGE-MGC_LOAD
InterPro	C1-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DAG/PE-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RBD_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64363	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:124609	IMAGE-MGC_LOAD
NCBI Gene	Araf	ENTREZGENE
PANTHER	NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE-THREONINE PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	RBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Araf	PhenoGen
PRINTS	DAGPEDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010838	RatGTEx
SMART	RBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00109	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Protein kinase-like (PK-like)	UniProtKB/TrEMBL
	SSF54236	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot
	SSF57889	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC228361
UniProt	A0A8I5ZXA9	ENTREZGENE, UniProtKB/TrEMBL
	A6JZR2	ENTREZGENE, UniProtKB/TrEMBL
	A6JZR3	ENTREZGENE, UniProtKB/TrEMBL
	A6JZR6	ENTREZGENE, UniProtKB/TrEMBL
	A6JZR7	ENTREZGENE, UniProtKB/TrEMBL
	A6JZR8_RAT	UniProtKB/TrEMBL
	A6JZR9	ENTREZGENE, UniProtKB/TrEMBL
	A6JZS1	ENTREZGENE, UniProtKB/TrEMBL
	A6JZS2_RAT	UniProtKB/TrEMBL
	A6JZS3_RAT	UniProtKB/TrEMBL
	ARAF_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6P9W2	ENTREZGENE
UniProt Secondary	Q6P9W2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-09	Araf	A-Raf proto-oncogene, serine/threonine kinase	Araf	v-raf murine sarcoma 3611 viral oncogene homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Araf	v-raf murine sarcoma 3611 viral oncogene homolog	Araf1	v-raf oncogene homolog 1 (murine sarcoma 3611 virus)	Symbol and Name updated	1299863	APPROVED
2004-12-14	Araf1	v-raf oncogene homolog 1 (murine sarcoma 3611 virus)		v-raf murine sarcoma 3611 viral oncogene homolog 1	Name updated	1299863	APPROVED
2002-06-10	Araf1	v-raf murine sarcoma 3611 viral oncogene homolog 1			Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	highly expressed in heart and liver throughout lifespan	70317
gene_function	phosphorylates protein serine/threonine residues	70317
gene_product	member of the raf protein-Ser/Thr kinase family	70317
gene_protein	67 kDa	70317

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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