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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2148
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Araf
Name: A-Raf proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arafaffects methylationISOARAF (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ARAF 5' UTR; Benzo(a)pyrene affects the methylation of ARAF promoterPMID:27901495
Arafdecreases expressionISOAraf (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ARAF mRNAPMID:23735875
Arafdecreases expressionISOARAF (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ARAF mRNAPMID:22316170
Arafdecreases methylationISOARAF (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of ARAF 3' UTRPMID:27901495
Arafincreases methylationISOARAF (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ARAF exonPMID:27901495
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