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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:64354
Term: metolazone
Definition: A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Chemical ID: MESH:D008788
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDMetolazone results in increased activity of NR1I2 proteinPMID:25455453
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNAPMID:25455453
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