ouabain - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	ouabain	go back to main search page
Accession:	CHEBI:472805	browse the term
Definition:	A multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+(/K)+)-ATPase (sodium pump).
Synonyms:	exact_synonym:	3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide
	related_synonym:	3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide; C29H44O12; G-Strophanthin; InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1; InChIKey=LPMXVESGRSUGHW-HBYQJFLCSA-N; Ouabagenin L-Rhamnoside; Ouabagenin-L-rhamnosid; Ouabain anhydrous; Ouabaine; Oubain; Strodival; [H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]1(C)[C@H](CC[C@]21O)C1=CC(=O)OC1)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
	alt_id:	CHEBI:44461; CHEBI:7805
	xref_casrn:	630-60-4
	xref:	Beilstein:101712 "Beilstein Registry Number"; ChEMBL:472805 "ChEMBL COMPOUND"; ChemIDplus:630-60-4 "CAS Registry Number"; CiteXplore:10438974 "PubMed citation"; DrugBank:DB01092 "DrugBank"; KEGG COMPOUND:630-60-4 "CAS Registry Number"; KEGG COMPOUND:C01443 "KEGG COMPOUND"; KEGG DRUG:D00112 "KEGG DRUG"
	xref_mesh:	MESH:D010042
	xref:	PDBeChem:OBN "PDBeChem"

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ouabain
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	A2m	alpha-2-macroglobulin		affects expression	ISO	4	158,103,711	158,153,423	RGD:6480464	CTD
G	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A		multiple interactions	ISO	4	21,709,855	21,796,628	RGD:6480464	CTD
G	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A		increases expression	ISO	4	21,709,855	21,796,628	RGD:6480464	CTD
G	Acaa2	acetyl-CoA acyltransferase 2		affects expression	ISO	18	71,587,259	71,632,610	RGD:6480464	CTD
G	Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1		affects expression	EXP	10	95,361,338	95,381,455	RGD:6480464	CTD
G	Adh1	alcohol dehydrogenase 1 (class I)		affects expression	ISO	2	235,799,396	235,811,584	RGD:6480464	CTD
G	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		affects expression	EXP	19	54,738,556	54,750,349	RGD:6480464	CTD
G	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		increases expression	EXP	19	54,738,556	54,750,349	RGD:6480464	CTD
G	Agtr1a	angiotensin II receptor, type 1a		decreases expression	EXP	17	40,629,318	40,684,982	RGD:6480464	CTD
G	Agtr1a	angiotensin II receptor, type 1a		affects expression	EXP	17	40,629,318	40,684,982	RGD:6480464	CTD
G	Anxa1	annexin A1		affects expression	ISO	1	223,478,436	223,494,455	RGD:6480464	CTD
G	Anxa2	annexin A2		affects expression	ISO	8	73,897,618	73,934,041	RGD:6480464	CTD
G	Araf	v-raf murine sarcoma 3611 viral oncogene homolog		decreases expression	ISO	X	12,556,904	12,568,583	RGD:6480464	CTD
G	Arih1	ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)		decreases expression	ISO	8	63,201,871	63,305,302	RGD:6480464	CTD
G	Arpc5	actin related protein 2/3 complex, subunit 5		affects expression	ISO	13	67,755,352	67,764,261	RGD:6480464	CTD
G	Arrb1	arrestin, beta 1		increases expression	ISO	1	156,871,564	156,937,540	RGD:6480464	CTD
G	Asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1		affects expression	ISO	16	54,279,253	54,311,084	RGD:6480464	CTD
G	Atp12a	ATPase, H+/K+ transporting, nongastric, alpha polypeptide		multiple interactions	ISO	15	35,295,274	35,321,453	RGD:6480464	CTD
G	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide		multiple interactions	ISO	2	196,657,749	196,687,242	RGD:6480464	CTD
G	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide		affects binding	ISO	2	196,657,749	196,687,242	RGD:6480464	CTD
G	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide		increases expression	ISO	2	196,657,749	196,687,242	RGD:6480464	CTD
G	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide		affects expression	EXP	2	196,657,749	196,687,242	RGD:6480464	CTD
G	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide		increases expression	EXP	2	196,657,749	196,687,242	RGD:6480464	CTD
G	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide		increases expression	EXP	2	196,657,749	196,687,242	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		multiple interactions	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		affects binding	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		increases expression	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		affects response to substance	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		multiple interactions	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		decreases activity	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		multiple interactions	EXP	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		affects expression	EXP	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		decreases expression	EXP	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		increases expression	EXP	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		increases expression	EXP	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide		affects response to substance	ISO	13	88,258,993	88,283,918	RGD:6480464	CTD
G	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide		increases expression	ISO	1	80,280,714	80,309,834	RGD:6480464	CTD
G	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide		affects binding	ISO	1	80,280,714	80,309,834	RGD:6480464	CTD
G	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide		multiple interactions	EXP	1	80,280,714	80,309,834	RGD:6480464	CTD
G	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide		affects expression	EXP	1	80,280,714	80,309,834	RGD:6480464	CTD
G	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide		decreases expression	EXP	1	80,280,714	80,309,834	RGD:6480464	CTD
G	Atp1a3	ATPase, Na+/K+ transporting, alpha 3 polypeptide		decreases expression	EXP	1	80,280,714	80,309,834	RGD:6480464	CTD
G	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide		multiple interactions	EXP	13	80,214,056	80,234,576	RGD:6480464	CTD
G	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide		increases expression	EXP	13	80,214,056	80,234,576	RGD:6480464	CTD
G	Atp4b	ATPase, H+/K+ exchanging, beta polypeptide		multiple interactions	ISO	16	81,000,154	81,009,067	RGD:6480464	CTD
G	Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle		affects expression	ISO	18	74,735,267	74,743,088	RGD:6480464	CTD
G	Bahd1	bromo adjacent homology domain containing 1		decreases expression	ISO	3	105,429,028	105,437,536	RGD:6480464	CTD
G	Bax	Bcl2-associated X protein		affects localization	ISO	1	95,933,023	95,938,176	RGD:6480464	CTD
G	Bax	Bcl2-associated X protein		multiple interactions	ISO	1	95,933,023	95,938,176	RGD:6480464	CTD
G	Bax	Bcl2-associated X protein		increases expression	ISO	1	95,933,023	95,938,176	RGD:6480464	CTD
G	Bdnf	brain-derived neurotrophic factor		multiple interactions	EXP				RGD:6480464	CTD
G	Bdnf	brain-derived neurotrophic factor		decreases expression	EXP				RGD:6480464	CTD
G	Calb1	calbindin 1		decreases expression	EXP	5	30,455,665	30,480,122	RGD:6480464	CTD
G	Calml5	calmodulin-like 5		affects expression	ISO	17	77,567,314	77,571,711	RGD:6480464	CTD
G	Canx	calnexin		increases expression	ISO	10	35,850,944	35,883,494	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases expression	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	EXP	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Cat	catalase		multiple interactions	EXP	3	88,654,077	88,686,212	RGD:6480464	CTD
G	Cat	catalase		decreases activity	EXP	3	88,654,077	88,686,212	RGD:6480464	CTD
G	Ccdc14	coiled-coil domain containing 14		decreases expression	ISO	11	67,872,420	67,905,568	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	EXP	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	EXP	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccna1	cyclin A1		decreases expression	ISO	2	144,275,211	144,285,196	RGD:6480464	CTD
G	Ccna2	cyclin A2		decreases expression	ISO	2	123,062,752	123,069,085	RGD:6480464	CTD
G	Cdk2	cyclin dependent kinase 2		decreases expression	ISO	7	2,000,196	2,007,682	RGD:6480464	CTD
G	Cdk2	cyclin dependent kinase 2		decreases expression	ISO	7	2,000,196	2,007,682	RGD:6480464	CTD
G	Cdk2	cyclin dependent kinase 2		decreases expression	ISO	7	2,000,196	2,007,682	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		decreases expression	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Ckb	creatine kinase, brain		decreases activity	EXP	6	136,452,215	136,455,122	RGD:6480464	CTD
G	Cldn1	claudin 1		decreases expression	ISO	11	76,473,654	76,488,809	RGD:6480464	CTD
G	Cnpy2	canopy 2 homolog (zebrafish)		affects expression	ISO	7	1,611,268	1,615,873	RGD:6480464	CTD
G	Cs	citrate synthase		decreases activity	EXP	7	1,626,181	1,652,197	RGD:6480464	CTD
G	Cyc1	cytochrome c-1		multiple interactions	ISO	7	114,394,178	114,396,563	RGD:6480464	CTD
G	Ddost	dolichyl-diphosphooligosaccharide-protein glycosyltransferase		decreases expression	ISO	5	157,083,337	157,090,071	RGD:6480464	CTD
G	Drd1	dopamine receptor D1		multiple interactions	ISO	17	16,655,926	16,658,161	RGD:6480464	CTD
G	Drd1	dopamine receptor D1		decreases expression	ISO	17	16,655,926	16,658,161	RGD:6480464	CTD
G	Drd1	dopamine receptor D1		multiple interactions	EXP	17	16,655,926	16,658,161	RGD:6480464	CTD
G	Dsg1	desmoglein 1		affects expression	ISO	18	12,127,180	12,156,469	RGD:6480464	CTD
G	Dut	deoxyuridine triphosphatase		affects expression	ISO	3	112,551,434	112,562,434	RGD:6480464	CTD
G	Ece1	endothelin converting enzyme 1		increases expression	ISO	5	156,635,656	156,735,783	RGD:6480464	CTD
G	Echs1	enoyl CoA hydratase, short chain, 1, mitochondrial		affects expression	ISO	1	199,901,585	199,910,412	RGD:6480464	CTD
G	Edn1	endothelin 1		increases expression	EXP	17	28,303,886	28,309,775	RGD:6480464	CTD
G	Ednra	endothelin receptor type A		increases expression	EXP	19	32,042,366	32,108,153	RGD:6480464	CTD
G	Ednra	endothelin receptor type A		increases expression	EXP	19	32,042,366	32,108,153	RGD:6480464	CTD
G	Ednra	endothelin receptor type A		increases expression	EXP	19	32,042,366	32,108,153	RGD:6480464	CTD
G	Eif3k	eukaryotic translation initiation factor 3, subunit K		affects expression	ISO	1	84,083,646	84,088,799	RGD:6480464	CTD
G	Fars2	phenylalanyl-tRNA synthetase 2, mitochondrial		increases expression	ISO	17	34,595,255	35,048,596	RGD:6480464	CTD
G	Fbxo32	F-box protein 32		multiple interactions	ISO	7	94,909,568	94,942,444	RGD:6480464	CTD
G	Fh	fumarate hydratase		affects expression	ISO	13	91,329,837	91,355,722	RGD:6480464	CTD
G	Fkbp7	FK506 binding protein 7		increases expression	ISO	3	59,361,703	59,373,382	RGD:6480464	CTD
G	Gc	group specific component		affects expression	ISO	14	20,166,243	20,197,060	RGD:6480464	CTD
G	Glrb	glycine receptor, beta		increases expression	ISO	2	172,451,807	172,522,841	RGD:6480464	CTD
G	Gtpbp6	GTP binding protein 6 (putative)		increases expression	ISO	12	46,722,131	46,726,000	RGD:6480464	CTD
G	Hgf	hepatocyte growth factor		multiple interactions	EXP	4	14,864,357	14,932,513	RGD:6480464	CTD
G	Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)		increases activity	ISO	6	96,419,024	96,463,891	RGD:6480464	CTD
G	Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)		affects localization	ISO	6	96,419,024	96,463,891	RGD:6480464	CTD
G	Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)		multiple interactions	ISO	6	96,419,024	96,463,891	RGD:6480464	CTD
G	Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1		affects expression	ISO	4	79,700,327	79,704,116	RGD:6480464	CTD
G	Hnrpdl	heterogeneous nuclear ribonucleoprotein D-like		decreases expression	ISO	14	10,861,054	10,864,322	RGD:6480464	CTD
G	Hpcal1	hippocalcin-like 1		affects expression	ISO	6	41,458,062	41,576,771	RGD:6480464	CTD
G	Hrg	histidine-rich glycoprotein		affects expression	ISO	11	80,248,578	80,264,179	RGD:6480464	CTD
G	Hspd1	heat shock protein 1 (chaperonin)		affects expression	ISO	9	53,884,193	53,895,043	RGD:6480464	CTD
G	Hspd1	heat shock protein 1 (chaperonin)		multiple interactions	ISO	9	53,884,193	53,895,043	RGD:6480464	CTD
G	Il2ra	interleukin 2 receptor, alpha		decreases expression	ISO	17	78,050,491	78,097,802	RGD:6480464	CTD
G	Il2rb	interleukin 2 receptor, beta		decreases expression	ISO				RGD:6480464	CTD
G	Kcnd2	potassium voltage-gated channel, Shal-related subfamily, member 2		increases expression	ISO	4	47,541,787	48,047,924	RGD:6480464	CTD
G	Kcnd2	potassium voltage-gated channel, Shal-related subfamily, member 2		increases expression	EXP	4	47,541,787	48,047,924	RGD:6480464	CTD
G	Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2		decreases expression	ISO	4	6,192,644	6,224,285	RGD:6480464	CTD
G	Lgals1	lectin, galactoside-binding, soluble, 1		affects expression	ISO	7	116,893,662	116,896,768	RGD:6480464	CTD
G	Lgals1	lectin, galactoside-binding, soluble, 1		increases expression	ISO	7	116,893,662	116,896,768	RGD:6480464	CTD
G	Lss	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)		increases abundance	ISO	20	12,507,575	12,534,612	RGD:6480464	CTD
G	Mapk1	mitogen activated protein kinase 1		multiple interactions	EXP	11	85,968,732	86,030,387	RGD:6480464	CTD
G	Mapk1	mitogen activated protein kinase 1		increases phosphorylation	EXP	11	85,968,732	86,030,387	RGD:6480464	CTD
G	Mapk3	mitogen activated protein kinase 3		multiple interactions	EXP	1	185,935,044	185,941,245	RGD:6480464	CTD
G	Mapk3	mitogen activated protein kinase 3		increases phosphorylation	EXP	1	185,935,044	185,941,245	RGD:6480464	CTD
G	Mapk7	mitogen-activated protein kinase 7		multiple interactions	ISO	10	47,649,203	47,654,316	RGD:6480464	CTD
G	Mdh2	malate dehydrogenase 2, NAD (mitochondrial)		affects expression	ISO	12	22,021,302	22,034,257	RGD:6480464	CTD
G	Myc	myelocytomatosis oncogene		decreases expression	ISO	7	98,953,142	98,958,060	RGD:6480464	CTD
G	Myc	myelocytomatosis oncogene		increases expression	ISO	7	98,953,142	98,958,060	RGD:6480464	CTD
G	Myl12a	myosin, light chain 12A, regulatory, non-sarcomeric		increases expression	ISO	9	110,190,030	110,197,715	RGD:6480464	CTD
G	Nos1	nitric oxide synthase 1, neuronal		affects expression	EXP	12	39,812,500	39,869,484	RGD:6480464	CTD
G	Nos1	nitric oxide synthase 1, neuronal		increases expression	EXP	12	39,812,500	39,869,484	RGD:6480464	CTD
G	Nos3	nitric oxide synthase 3, endothelial cell		multiple interactions	EXP	4	6,158,847	6,179,441	RGD:6480464	CTD
G	Nos3	nitric oxide synthase 3, endothelial cell		increases expression	EXP	4	6,158,847	6,179,441	RGD:6480464	CTD
G	Nos3	nitric oxide synthase 3, endothelial cell		affects expression	EXP	4	6,158,847	6,179,441	RGD:6480464	CTD
G	Npc2	Niemann-Pick disease, type C2		decreases expression	ISO	6	108,793,935	108,814,703	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		increases expression	EXP	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		multiple interactions	EXP	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		multiple interactions	EXP	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Park7	parkinson protein 7		affects response to substance	ISO	5	168,050,149	168,061,616	RGD:6480464	CTD
G	Pcna	proliferating cell nuclear antigen		decreases expression	ISO	3	120,008,715	120,012,589	RGD:6480464	CTD
G	Pcna	proliferating cell nuclear antigen		decreases expression	ISO	3	120,008,715	120,012,589	RGD:6480464	CTD
G	Pcna	proliferating cell nuclear antigen		decreases expression	ISO	3	120,008,715	120,012,589	RGD:6480464	CTD
G	Pdcd6	programmed cell death 6		increases expression	ISO	1	29,769,911	29,785,577	RGD:6480464	CTD
G	Pfdn5	prefoldin subunit 5		affects expression	ISO	7	141,075,469	141,080,207	RGD:6480464	CTD
G	Pfn1	profilin 1		affects expression	ISO	10	57,531,661	57,534,366	RGD:6480464	CTD
G	Pfn1	profilin 1		decreases expression	ISO	10	57,531,661	57,534,366	RGD:6480464	CTD
G	Potef	POTE ankyrin domain family, member F		affects expression	ISO	18	24,420,779	24,422,284	RGD:6480464	CTD
G	Ppt2	palmitoyl-protein thioesterase 2		decreases expression	ISO	20	4,225,630	4,234,653	RGD:6480464	CTD
G	Psmb6	proteasome (prosome, macropain) subunit, beta type 6		affects expression	ISO	10	57,370,397	57,372,704	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		multiple interactions	EXP	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		increases expression	EXP	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptpn2	protein tyrosine phosphatase, non-receptor type 2		decreases expression	ISO	18	64,205,920	64,271,288	RGD:6480464	CTD
G	Rab11b	RAB11B, member RAS oncogene family		increases expression	ISO	7	16,232,840	16,246,007	RGD:6480464	CTD
G	Rock1	Rho-associated coiled-coil containing protein kinase 1		increases cleavage	ISO	18	1,391,751	1,511,865	RGD:6480464	CTD
G	Rock1	Rho-associated coiled-coil containing protein kinase 1		multiple interactions	ISO	18	1,391,751	1,511,865	RGD:6480464	CTD
G	Rock2	Rho-associated coiled-coil containing protein kinase 2		multiple interactions	ISO	6	40,581,247	40,672,854	RGD:6480464	CTD
G	Rock2	Rho-associated coiled-coil containing protein kinase 2		increases cleavage	ISO	6	40,581,247	40,672,854	RGD:6480464	CTD
G	Rpa3	replication protein A3		affects expression	ISO	4	33,304,334	33,307,365	RGD:6480464	CTD
G	Rpgrip1l	Rpgrip1-like		decreases expression	ISO	19	16,859,114	16,952,054	RGD:6480464	CTD
G	Ryr2	ryanodine receptor 2, cardiac		multiple interactions	ISO	17	68,959,042	69,544,816	RGD:6480464	CTD
G	Ryr2	ryanodine receptor 2, cardiac		increases response to substance	ISO	17	68,959,042	69,544,816	RGD:6480464	CTD
G	S100a13	S100 calcium binding protein A13		affects expression	ISO	2	182,790,173	182,796,668	RGD:6480464	CTD
G	S100b	S100 calcium binding protein B		increases expression	EXP	20	12,791,440	12,824,508	RGD:6480464	CTD
G	Sgk1	serum/glucocorticoid regulated kinase 1		multiple interactions	ISO	1	23,501,257	23,506,651	RGD:6480464	CTD
G	Sgk2	serum/glucocorticoid regulated kinase 2		multiple interactions	ISO	3	153,849,825	153,890,111	RGD:6480464	CTD
G	Slc22a12	solute carrier family 22 (organic anion/urate transporter), member 12		multiple interactions	ISO	1	209,320,804	209,327,918	RGD:6480464	CTD
G	Slc5a5	solute carrier family 5 (sodium iodide symporter), member 5		multiple interactions	ISO	16	19,046,200	19,056,281	RGD:6480464	CTD
G	Slc5a6	solute carrier family 5 (sodium-dependent vitamin transporter), member 6		multiple interactions	ISO	6	25,301,630	25,312,901	RGD:6480464	CTD
G	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1		affects response to substance	ISO	6	4,421,046	4,691,716	RGD:6480464	CTD
G	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1		multiple interactions	EXP	6	4,421,046	4,691,716	RGD:6480464	CTD
G	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1		multiple interactions	EXP	6	4,421,046	4,691,716	RGD:6480464	CTD
G	Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1		increases expression	EXP	6	4,421,046	4,691,716	RGD:6480464	CTD
G	Slc9a1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1		multiple interactions	EXP	5	151,680,696	151,748,460	RGD:6480464	CTD
G	Slc9a1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1		increases expression	EXP	5	151,680,696	151,748,460	RGD:6480464	CTD
G	Tpi1	triosephosphate isomerase 1		affects expression	ISO	4	160,933,341	160,936,871	RGD:6480464	CTD
G	Tpt1	tumor protein, translationally-controlled 1		affects expression	ISO	15	56,752,464	56,755,288	RGD:6480464	CTD
G	Trim63	tripartite motif containing 63, E3 ubiquitin protein ligase		multiple interactions	ISO	5	153,059,573	153,073,907	RGD:6480464	CTD
G	Trpc1	transient receptor potential cation channel, subfamily C, member 1		increases expression	EXP	8	100,770,833	100,821,420	RGD:6480464	CTD
G	Trpc6	transient receptor potential cation channel, subfamily C, member 6		increases expression	EXP	8	5,472,515	5,577,537	RGD:6480464	CTD
G	Trpc6	transient receptor potential cation channel, subfamily C, member 6		multiple interactions	EXP	8	5,472,515	5,577,537	RGD:6480464	CTD
G	Trpc6	transient receptor potential cation channel, subfamily C, member 6		multiple interactions	EXP	8	5,472,515	5,577,537	RGD:6480464	CTD
G	Txn1	thioredoxin 1		affects expression	ISO	5	75,921,365	75,933,595	RGD:6480464	CTD
G	Zfhx3	zinc finger homeobox 3		decreases expression	ISO	19	38,547,428	38,783,613	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	492574
role	482262
chemical role	208077
inhibitor	73170
enzyme inhibitor	68950
ouabain	177
Path 2
Term	Annotations
CHEBI ontology	492574
subatomic particle	491537
composite particle	491537
hadron	491537
baryon	491537
nucleon	491537
atomic nucleus	491537
atom	491537
main group element atom	461203
p-block element atom	458699
carbon group element atom	410677
carbon atom	407233
organic molecular entity	407226
organic group	167766
organic divalent group	166601
organodiyl group	166601
carbonyl group	166291
carbonyl compound	166291
carboxylic ester	33819
lactone	8941
gamma-lactone	1354
butenolide	268
cardenolide	268
cardenolide glycoside	268
ouabain	177