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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2168
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp1a2
Name: ATPase Na+/K+ transporting subunit alpha 2
Acc ID: CHEBI:472805
Term: ouabain
Definition: A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Chemical ID: MESH:D010042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp1a2affects expressionEXP 6480464CTDOuabain affects the expression of ATP1A2 proteinPMID:11834625
Atp1a2decreases expressionEXP 6480464CTDOuabain results in decreased expression of ATP1A2 mRNAPMID:19687166
Atp1a2increases expressionEXP 6480464CTDOuabain results in increased expression of ATP1A2 proteinPMID:16716361 PMID:19897708
Atp1a2multiple interactionsEXP 6480464CTDN-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]PMID:19687166
Atp1a2affects bindingISOATP1A2 (Homo sapiens)6480464CTDOuabain binds to ATP1A2 proteinPMID:12479229
Atp1a2affects response to substanceISOAtp1a2 (Mus musculus)6480464CTDATP1A2 protein affects the susceptibility to OuabainPMID:15458945 PMID:16166162
Atp1a2decreases activityISOAtp1a2 (Mus musculus)6480464CTDOuabain results in decreased activity of ATP1A2 proteinPMID:16166162
Atp1a2increases expressionISOATP1A2 (Homo sapiens)6480464CTDOuabain results in increased expression of ATP1A2 mRNAPMID:19995221
Atp1a2multiple interactionsISOAtp1a2 (Mus musculus)6480464CTDOuabain binds to and results in decreased activity of ATP1A2 proteinPMID:18487447
Atp1a2multiple interactionsISOATP1A2 (Homo sapiens)6480464CTDLithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]PMID:19995221
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