Alc25 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Alc25 (Alcohol consumption QTL 25) Rattus norvegicus

Symbol: Alc25
Name: Alcohol consumption QTL 25
RGD ID: 8693618
Trait: drinking behavior trait   (VT:0001422)    
Measurement Type: calculated ethanol drink intake rate   (CMO:0001615)    
LOD Score: 3.0
P Value: 0.28
Variance: Not Available
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01227,509,470 - 249,252,048RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01234,574,271 - 256,490,738RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41213,847,769 - 234,642,714RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: BXH/Ipcv HXB/Ipcv 

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Measurement Method
scale  (IDA)

Vertebrate Trait

Rat Strain
BXH/Ipcv  (IEA)
HXB/Ipcv  (IEA)


References - curated
# Reference Title Reference Citation
1. Is the Alcohol Deprivation Effect Genetically Mediated? Studies with HXB/BXH Recombinant Inbred Rat Strains. Vanderlinden LA, etal., Alcohol Clin Exp Res. 2014 Jun 24. doi: 10.1111/acer.12471.


Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (rs107452597)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01227,509,470 - 227,509,470RGD
Rnor_5.01234,574,271 - 234,574,271RGD
RGSC_v3.41213,847,769 - 213,847,769RGD
Celera1205,462,252 - 205,462,252RGD
Peak: (rs64042903)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01241,320,305 - 241,320,305RGD
Rnor_5.01248,602,148 - 248,602,148RGD
RGSC_v3.41226,850,093 - 226,850,093RGD
Celera1218,326,594 - 218,326,594RGD
Flank 2: (rs64209861)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01249,252,048 - 249,252,048RGD
Rnor_5.01256,490,738 - 256,490,738RGD
RGSC_v3.41234,642,714 - 234,642,714RGD
Celera1225,759,203 - 225,759,203RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general spans 234.9-256.4 Mb 8663441
qtl_general measurement method: rats were given 10% EtOH for 1 week, then for 7 weeks they were given 2-bottle choice of water and EtOH followed by 2 week period of only water (alcohol deprivation); then 2 weeks of 2-bottle choice of water and EtOH followed by second 2 weeks of alcohol deprivation then 2 weeks of 2-bottle choice of water and EtOH followed by third 2 weeks of alcohol deprivation and 1 week of 2-bottle choice of water and EtOH 8663441
qtl_general water and alcohol consumption were measured by weight 8663441
qtl_general alcohol deprivation effect (ADE) was calculated as the amount of alcohol consumed (g/kg) during 24 hrs after deprivation minus average daily amount consumed in the week before deprivation period 8663441
qtl_general this QTL correlates to week 2 pre-ADE alcohol consumption 8663441
qtl_general software used: ANOVA 8663441
qtl_general number of animals used: 70-100 days old males from HXB/BXH RI strains and the parental BN-Lx/CubPrin, SHR/OlaIpcvPrin 8663441