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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:desipramine
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Accession:CHEBI:47781 term browser browse the term
Definition:A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Synonyms:related_synonym: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE;   5-(gamma-methylaminopropyl)iminodibenzyl;   DMI;   Desipramin;   Formula=C18H22N2;   InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3;   InChIKey=HCYAFALTSJYZDH-UHFFFAOYSA-N;   N-(3-methylaminopropyl)iminobibenzyl;   SMILES=CNCCCN1c2ccccc2CCc2ccccc12;   demethylimipramine;   desipramina;   desipraminum;   desmethylimipramine;   monodemethylimipramine;   norimipramine
 alt_id: CHEBI:4448;   CHEBI:47393
 xref: Beilstein:1432747;   CAS:50-47-5;   DrugBank:DB01151;   Drug_Central:812;   HMDB:HMDB0015282;   KEGG:C06943;   KEGG:D07791;   LINCS:LSM-3351
 xref_mesh: MESH:D003891
 xref: PDBeChem:DSM;   PMID:11041270;   PMID:11287497;   PMID:19328214;   PMID:20825390;   PMID:24399719;   Reaxys:1432747;   Wikipedia:Desipramine



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desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases activity ISO Desipramine results in increased activity of ACHE protein CTD PMID:29614332 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Desipramine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Desipramine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP Desipramine results in increased expression of ARC mRNA CTD PMID:14580947 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Desipramine results in increased expression of BCL2 mRNA; Desipramine results in increased expression of BCL2 protein CTD PMID:17510525 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Desipramine results in increased expression of BDNF mRNA CTD PMID:15555640 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression ISO Desipramine results in decreased expression of CAMKK1 mRNA CTD PMID:15555640 NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression ISO Desipramine results in decreased expression of CAMKK2 mRNA CTD PMID:15555640 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased cleavage of and results in increased activity of CASP3 protein]; Desipramine results in increased cleavage of and results in increased activity of CASP3 protein
Desipramine results in increased activity of CASP3 protein
CTD PMID:18606486 PMID:18986328 PMID:20549303 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity EXP Desipramine results in increased activity of CASP9 protein CTD PMID:20549303 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Desipramine inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:17477857 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Desipramine results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Desipramine results in decreased activity of CYP2C19 protein CTD PMID:15135088 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Desipramine CTD PMID:15286053 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Desipramine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases response to substance
decreases activity
ISO CYP3A4 protein results in increased susceptibility to Desipramine
Desipramine results in decreased activity of CYP3A4 protein
CTD PMID:15135088 PMID:21540358 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Desipramine CTD PMID:15148402 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects response to substance
increases expression
EXP DDIT3 affects the susceptibility to Desipramine
Desipramine results in increased expression of DDIT3 protein
CTD PMID:20549303 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egr1 early growth response 1 decreases expression EXP Desipramine results in decreased expression of EGR1 mRNA CTD PMID:7612155 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Desipramine results in decreased expression of FOS mRNA CTD PMID:7612155 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP Desipramine inhibits the reaction [Reserpine results in increased expression of GAL mRNA] CTD PMID:1717808 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 affects localization EXP Desipramine affects the localization of GRK2 protein CTD PMID:12527474 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 affects localization EXP Desipramine affects the localization of GRK3 protein CTD PMID:12527474 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases expression
ISO
EXP
Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]
Desipramine results in increased expression of HTR1A protein
CTD PMID:1589591 PMID:15885359 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression EXP Desipramine results in decreased expression of HTR2A; Desipramine results in decreased expression of HTR2A protein CTD PMID:1664741 PMID:2553044 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Il1b interleukin 1 beta increases secretion EXP Desipramine results in increased secretion of IL1B protein CTD PMID:16386803 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Desipramine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; Desipramine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of IL6 protein] CTD PMID:24951586 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Desipramine results in decreased activity of KCNH2 protein CTD PMID:20211602 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO Desipramine results in increased activity of MAPK1 protein CTD PMID:18986328 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity ISO Desipramine results in increased activity of MAPK14 protein CTD PMID:18986328 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO Desipramine results in increased activity of MAPK3 protein CTD PMID:18986328 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester promotes the reaction [Desipramine results in increased phosphorylation of MAPK8 protein] CTD PMID:18606486 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nes nestin increases expression EXP Desipramine results in increased expression of NES mRNA CTD PMID:17510525 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to Desipramine CTD PMID:21540358 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; Desipramine inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein] CTD PMID:15885359 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Plcb1 phospholipase C beta 1 decreases expression EXP Desipramine results in decreased expression of PLCB1 mRNA; Desipramine results in decreased expression of PLCB1 protein CTD PMID:12527476 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Desipramine results in increased expression of PPP1R15A protein CTD PMID:20549303 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc17a7 solute carrier family 17 member 7 increases expression ISO Desipramine results in increased expression of SLC17A7 mRNA; Desipramine results in increased expression of SLC17A7 protein CTD PMID:16111724 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Desipramine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions EXP
ISO
Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Desipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
CTD PMID:9830022 PMID:10966924 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]
Desipramine results in decreased activity of SLC6A2 protein
[Desipramine binds to and results in decreased activity of SLC6A2 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; [Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]
Desipramine results in decreased expression of SLC6A2 protein
CTD PMID:16725121 PMID:17234900 PMID:18561912 PMID:18923402 PMID:19616025 More... NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 decreases activity ISO Desipramine results in decreased activity of SMPD1 protein CTD PMID:15781658 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Desipramine results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Desipramine inhibits the reaction [Reserpine results in increased expression of TH mRNA] CTD PMID:1717808 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor decreases activity
multiple interactions
ISO Desipramine results in decreased activity of TNF protein
Desipramine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Desipramine inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:17477857 PMID:24951586 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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