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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dithioketal
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Accession:CHEBI:59800 term browser browse the term
Definition:A dithioacetal of formula R2C(SR')2, R =/= H, R' =/= H.
Synonyms:related_synonym: dithioketals


show annotations for term's descendants           Sort by:
probucol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Probucol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoe apolipoprotein E affects response to substance
decreases response to substance
multiple interactions		 ISO APOE protein affects the susceptibility to Probucol
APOE protein results in decreased susceptibility to Probucol
Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of FCER1G mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of LILRB3 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of SELPLG mRNA]		 CTD PMID:10998462 PMID:19394937 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Probucol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Probucol inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Probucol inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 PMID:28734741 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Probucol inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:11291592 PMID:26111763 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C1qc complement C1q C chain multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA] CTD PMID:19394937 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]] CTD PMID:19967051 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cfl1 cofilin 1 multiple interactions ISO Probucol inhibits the reaction [methylmercury II affects the localization of and results in decreased phosphorylation of CFL1 protein] CTD PMID:27241350 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Cttn cortactin multiple interactions ISO Probucol inhibits the reaction [methylmercury II results in increased expression of CTTN mRNA] CTD PMID:27241350 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA] CTD PMID:19394937 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dock2 dedicator of cytokinesis 2 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA] CTD PMID:19394937 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Probucol inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fcer1g Fc epsilon receptor Ig multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of FCER1G mRNA] CTD PMID:19394937 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Probucol promotes the reaction [Dietary Fats results in decreased expression of GATA4 protein modified form] CTD PMID:30240538 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein] CTD PMID:28881715 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity		 ISO
EXP		 Probucol inhibits the reaction [methylmercuric chloride results in decreased activity of GPX1 protein]; Probucol promotes the reaction [methylmercury II results in decreased expression of GPX1 mRNA]
Probucol results in increased activity of GPX1 protein
Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]; Probucol inhibits the reaction [Doxorubicin results in decreased expression of GPX1 protein]		 CTD PMID:7805190 PMID:19770487 PMID:27241350 PMID:28734741 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Probucol results in increased expression of HMOX1 mRNA
HMOX1 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]
NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]		 CTD PMID:23942037 PMID:28881715 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Probucol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone] CTD PMID:23942037 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:28881715 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:28881715 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA] CTD PMID:19394937 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Probucol results in decreased activity of KCNH2 protein SNP CTD PMID:15043509 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Limk1 LIM domain kinase 1 multiple interactions ISO Probucol inhibits the reaction [methylmercury II results in increased expression of LIMK1 mRNA] CTD PMID:27241350 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606 		JBrowse link
G Ly86 lymphocyte antigen 86 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA] CTD PMID:19394937 NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of MMP2 protein] CTD PMID:17964422 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:17964422 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 NFE2L2 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]
NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]		 CTD PMID:23942037 PMID:28881715 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein] CTD PMID:28881715 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Probucol inhibits the reaction [Fluorouracil results in decreased expression of PCNA protein] CTD PMID:19272435 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 mRNA]; Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 protein] CTD PMID:19272435 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pirb paired Ig-like receptor B multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of LILRB3 mRNA] CTD PMID:19394937 NCBI chr 1:65,499,195...65,506,666
Ensembl chr 1:65,499,195...65,506,666 		JBrowse link
G Sele selectin E multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selplg selectin P ligand multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of SELPLG mRNA] CTD PMID:19394937 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Snca synuclein alpha multiple interactions ISO Probucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] CTD PMID:16239214 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity		 EXP [Probucol co-treated with Doxorubicin] results in increased activity of SOD2 protein; Probucol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 mRNA]; Probucol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]
Probucol results in increased activity of SOD2 protein		 CTD PMID:10912462 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Spmip11 sperm microtubule inner protein 11 increases expression EXP Probucol results in increased expression of NPHS1 mRNA CTD PMID:11012881 NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Probucol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Probucol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 [cilostazol co-treated with Probucol] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]; Probucol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of SELE protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]]
NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Probucol decreases expression of Tnf mRNA in liver, protein in serum		 CTD
RGD		 PMID:16769766 PMID:17964422 PMID:19967051 PMID:28881715 PMID:19220660 RGD:2312478 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]] CTD PMID:16769766 PMID:19967051 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
spirapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ren renin increases expression
multiple interactions		 EXP spirapril results in increased expression of REN mRNA; spirapril results in increased expression of REN protein
spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]		 CTD PMID:1764812 PMID:9300315 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP		 spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19893
    chemical entity 19891
      atom 19891
        nonmetal atom 19814
          sulfur atom 17766
            sulfur molecular entity 17766
              organosulfur compound 17464
                thioacetal 307
                  dithioacetal 46
                    dithioketal 46
                      2,2,4,4,6,6-Hexamethyl-1,3,5-trithiane 0
                      Hexahydro-2',4-dimethylspiro[1,3-dithiolo[4,5-c]furan-2,3'(2'H)-furan] 0
                      methylsulfonal 0
                      probucol 43
                      spirapril 3
                      spiraprilat + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19893
    subatomic particle 19891
      composite particle 19891
        hadron 19891
          baryon 19891
            nucleon 19891
              atomic nucleus 19891
                atom 19891
                  main group element atom 19830
                    p-block element atom 19830
                      carbon group element atom 19771
                        carbon atom 19767
                          organic molecular entity 19767
                            heteroorganic entity 19525
                              organochalcogen compound 19286
                                organosulfur compound 17464
                                  thioacetal 307
                                    dithioacetal 46
                                      dithioketal 46
                                        2,2,4,4,6,6-Hexamethyl-1,3,5-trithiane 0
                                        Hexahydro-2',4-dimethylspiro[1,3-dithiolo[4,5-c]furan-2,3'(2'H)-furan] 0
                                        methylsulfonal 0
                                        probucol 43
                                        spirapril 3
                                        spiraprilat + 3
paths to the root