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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:probucol
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Accession:CHEBI:8427 term browser browse the term
Definition:A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Synonyms:exact_synonym: 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol)
 related_synonym: 4,4'- (Isopropylidenedithio)bis(2,6-di-tert-butylphenol);   Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole;   Biphenabid;   Bisbid;   Bisphenabid;   DH-581;   Formula=C31H48O2S2;   InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3;   InChIKey=FYPMFJGVHOHGLL-UHFFFAOYSA-N;   Lesterol;   Lorelco;   Lurselle;   SMILES=CC(C)(Sc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)Sc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C;   Serterol;   Superlipid;   probucolum
 xref: CAS:23288-49-5;   DrugBank:DB01599;   Drug_Central:2269;   HMDB:HMDB0015537;   KEGG:C07373;   KEGG:D00476;   LINCS:LSM-3617
 xref_mesh: MESH:D011341
 xref: PMID:22305809;   PMID:23107872;   PMID:23167559;   PMID:23334712;   PMID:23363981;   PMID:23378294;   PMID:23443157;   PMID:23741215;   Patent:CN101423484;   Patent:CN101455842;   Patent:CN102973535;   Patent:FR1561853;   Patent:US3576883;   Patent:US3862332;   Reaxys:2026253;   Wikipedia:Probucol



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probucol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Probucol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoe apolipoprotein E affects response to substance
decreases response to substance
multiple interactions
ISO APOE protein affects the susceptibility to Probucol
APOE protein results in decreased susceptibility to Probucol
Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of FCER1G mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of LILRB3 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA]; Probucol promotes the reaction [APOE gene mutant form results in increased expression of SELPLG mRNA]
CTD PMID:10998462 PMID:19394937 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein alternative form]; Probucol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; Probucol inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Probucol inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 PMID:28734741 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in increased expression of BAX mRNA]; Probucol inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:11291592 PMID:26111763 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] CTD PMID:26111763 NCBI chr13:22,689,783...22,853,920 JBrowse link
G C1qc complement C1q C chain multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of C1QC mRNA] CTD PMID:19394937 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]; Probucol promotes the reaction [Cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]] CTD PMID:19967051 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cfl1 cofilin 1 multiple interactions ISO Probucol inhibits the reaction [methylmercury II affects the localization of and results in decreased phosphorylation of CFL1 protein] CTD PMID:27241350 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Cttn cortactin multiple interactions ISO Probucol inhibits the reaction [methylmercury II results in increased expression of CTTN mRNA] CTD PMID:27241350 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of CXCR4 mRNA] CTD PMID:19394937 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Probucol inhibits the reaction [APP protein modified form results in increased expression of CYCS mRNA] CTD PMID:26111763 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Dock2 dedicator of cytokinesis 2 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA] CTD PMID:19394937 NCBI chr10:18,827,237...19,244,823 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Probucol inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of FCER1G mRNA] CTD PMID:19394937 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions EXP Probucol promotes the reaction [Dietary Fats results in decreased expression of GATA4 protein modified form] CTD PMID:30240538 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein] CTD PMID:28881715 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
ISO
EXP
Probucol inhibits the reaction [methylmercuric chloride results in decreased activity of GPX1 protein]; Probucol promotes the reaction [methylmercury II results in decreased expression of GPX1 mRNA]
Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of GPX1 mRNA]; Probucol inhibits the reaction [Doxorubicin results in decreased expression of GPX1 protein]
Probucol results in increased activity of GPX1 protein
CTD PMID:7805190 PMID:19770487 PMID:27241350 PMID:28734741 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
Probucol results in increased expression of HMOX1 mRNA
NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]
HMOX1 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]
CTD PMID:23942037 PMID:28881715 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO Probucol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone] CTD PMID:23942037 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:28881715 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:28881715 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of ITGB2 mRNA] CTD PMID:19394937 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Probucol results in decreased activity of KCNH2 protein SNP CTD PMID:15043509 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Limk1 LIM domain kinase 1 multiple interactions ISO Probucol inhibits the reaction [methylmercury II results in increased expression of LIMK1 mRNA] CTD PMID:27241350 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606
JBrowse link
G Ly86 lymphocyte antigen 86 multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA] CTD PMID:19394937 NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of MMP2 protein] CTD PMID:17964422 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:17964422 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
NFE2L2 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]
NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of GFAP protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]
CTD PMID:23942037 PMID:28881715 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression EXP Probucol results in increased expression of NPHS1 mRNA CTD PMID:11012881 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein] CTD PMID:28881715 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Probucol inhibits the reaction [Fluorouracil results in decreased expression of PCNA protein] CTD PMID:19272435 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 mRNA]; Probucol inhibits the reaction [Fluorouracil results in decreased expression of PECAM1 protein] CTD PMID:19272435 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pirb paired Ig-like receptor B multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of LILRB3 mRNA] CTD PMID:19394937
G Sele selectin E multiple interactions ISO Probucol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Selplg selectin P ligand multiple interactions ISO Probucol promotes the reaction [APOE gene mutant form results in increased expression of SELPLG mRNA] CTD PMID:19394937 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585
JBrowse link
G Snca synuclein alpha multiple interactions ISO Probucol inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] CTD PMID:16239214 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Probucol co-treated with Doxorubicin] results in increased activity of SOD2 protein; Probucol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 mRNA]; Probucol inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]
Probucol results in increased activity of SOD2 protein
CTD PMID:10912462 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of SOD3 mRNA] CTD PMID:28734741 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Probucol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Probucol inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
[cilostazol co-treated with Probucol] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]]; cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol inhibits the reaction [TNF protein results in increased expression of CCL2]; Probucol inhibits the reaction [TNF protein results in increased expression of MMP2 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of SELE protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of CCL2]]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]]
Probucol decreases expression of Tnf mRNA in liver, protein in serum
NFE2L2 protein affects the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Probucol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
RGD
PMID:16769766 PMID:17964422 PMID:19967051 PMID:28881715 PMID:19220660 RGD:2312478 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO cilostazol promotes the reaction [Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Probucol inhibits the reaction [TNF protein results in increased expression of VCAM1]; Probucol promotes the reaction [cilostazol inhibits the reaction [TNF protein results in increased expression of VCAM1]] CTD PMID:16769766 PMID:19967051 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

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  CHEBI ontology 19823
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                          organic molecular entity 19633
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                                  thioacetal 298
                                    dithioacetal 46
                                      dithioketal 46
                                        probucol 43
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