Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spirapril
go back to main search page
Accession:CHEBI:135756 term browser browse the term
Synonyms:exact_synonym: (8S)-7-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
 related_synonym: Formula=C22H30N2O5S2;   InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1;   InChIKey=HRWCVUIFMSZDJS-SZMVWBNQSA-N;   SMILES=C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
 xref: CAS:83647-97-6;   DrugBank:DB01348;   Drug_Central:2474;   HMDB:HMDB0015438;   KEGG:D08529
 xref_mesh: MESH:C052555
 xref: PMID:10499560;   PMID:10499561;   PMID:12613273;   PMID:8638865;   PMID:9345854;   Reaxys:4277924;   Wikipedia:Spirapril



show annotations for term's descendants           Sort by:
spirapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ren renin increases expression
multiple interactions
EXP spirapril results in increased expression of REN mRNA; spirapril results in increased expression of REN protein
spirapril promotes the reaction [2-hexynyladenosine-5'-N-ethylcarboxamide results in increased expression of REN protein]
CTD PMID:1764812 PMID:9300315 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:104,944,461...104,991,316
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP
spirapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:77,519,565...77,548,609
Ensembl chr11:64,014,182...64,043,225
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19879
    role 19850
      application 19693
        pro-agent 11552
          prodrug 11295
            spirapril 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19879
    subatomic particle 19877
      composite particle 19877
        hadron 19877
          baryon 19877
            nucleon 19877
              atomic nucleus 19877
                atom 19877
                  main group element atom 19816
                    p-block element atom 19816
                      carbon group element atom 19756
                        carbon atom 19753
                          organic molecular entity 19753
                            heteroorganic entity 19521
                              organochalcogen compound 19281
                                organooxygen compound 19199
                                  carbon oxoacid 18676
                                    carboxylic acid 18673
                                      carboacyl group 17706
                                        univalent carboacyl group 17706
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              peptide 11448
                                                oligopeptide 1358
                                                  dipeptide 414
                                                    spiraprilat 3
                                                      spirapril 3
paths to the root