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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpx1
Name: glutathione peroxidase 1
Acc ID: CHEBI:8427
Term: probucol
Definition: A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
Chemical ID: MESH:D011341
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx1multiple interactionsEXP 6480464CTDProbucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol Dietary] results in decreased expression of GPX1 mRNA] Probucol inhibits the reaction [Doxorubicin results in decreased expression of GPX1 protein]

PMID:28734741 PMID:7805190
Gpx1increases activityISORGD:106816480464CTDProbucol results in increased activity of GPX1 protein

PMID:19770487
Gpx1multiple interactionsISORGD:106816480464CTDProbucol inhibits the reaction [methylmercuric chloride results in decreased activity of GPX1 protein] Probucol promotes the reaction [methylmercury II results in decreased expression of GPX1 mRNA]

PMID:19770487 PMID:27241350
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