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1,3-benzothiazole-2-thiol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1,3-benzothiazole-2-thiol
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Accession:CHEBI:34292 term browser browse the term
Definition:1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.
Synonyms:related_synonym: 1,3-Benzothiazol-2-yl hydrosulfide;   2-Benzothiazolethiol;   2-MBT;   2-Mercaptobenzothiazole;   2-sulfanyl-1,3-benzothiazole;   Benzothiazole-2-thiol;   Benzothiazolethiol;   Captax;   Formula=C7H5NS2;   InChI=1S/C7H5NS2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9);   InChIKey=YXIWHUQXZSMYRE-UHFFFAOYSA-N;   MBT;   Mercaptobenzothiazole;   SMILES=Sc1nc2ccccc2s1;   benzothiazolyl mercaptan
 alt_id: CHEBI:282886
 xref: Beilstein:508810;   CAS:149-30-4;   KEGG:C14437;   LINCS:LSM-18993
 xref_mesh: MESH:C005563
 xref: PMID:18568896;   PMID:18844695;   PMID:19158128;   PMID:21616561;   PMID:23063874;   PMID:23178179;   PMID:23340394;   UM-BBD_compID:c1019

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1,3-benzothiazole-2-thiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO captax results in increased expression of AHR mRNA CTD PMID:21590714 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
increases expression		 ISO captax results in increased activity of AKR1C2 promoter
captax results in increased expression of AKR1C2 mRNA		 CTD PMID:20491607 PMID:20713136 PMID:21195160 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO captax results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:164,885,320...164,929,887 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO captax results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO captax results in decreased expression of CCL2 mRNA CTD PMID:20713136 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO captax results in increased secretion of CCL4 protein CTD PMID:16314067 NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO captax results in increased expression of CCR2 mRNA CTD PMID:20713136 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO captax results in increased expression of CCR5 mRNA CTD PMID:20713136 NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Cd86 CD86 molecule increases expression ISO captax results in increased expression of CD86 protein CTD PMID:12423654 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO captax results in decreased expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO captax results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO captax results in decreased expression of CXCL14 mRNA; captax results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO captax results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO captax results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO captax results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO captax results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO captax results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO captax results in increased expression of ENPP2 protein CTD PMID:22952646 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO captax results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO captax results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO captax results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO captax results in increased expression of GCLC mRNA CTD PMID:20491607 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO captax results in increased expression of GCLM mRNA CTD PMID:23999411 PMID:24211530 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO captax results in increased expression of H2AX protein
1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein]; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [captax results in increased expression of H2AX protein]; Acetylcysteine inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein]		 CTD PMID:35279910 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO captax results in increased expression of HMOX1 mRNA CTD PMID:20713136 PMID:23445166 PMID:24211530 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO captax results in increased expression of HSPA6 mRNA CTD PMID:23999411 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Ifng interferon gamma increases secretion ISO captax results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il18 interleukin 18 increases expression ISO captax results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO captax results in increased expression of IL1A protein
captax results in increased expression of IL1A mRNA		 CTD PMID:23178550 PMID:33715048 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion		 ISO captax results in increased expression of IL1B mRNA
captax results in increased secretion of IL1B protein		 CTD PMID:33715048 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 increases secretion ISO captax results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases secretion ISO captax results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il7r interleukin 7 receptor increases expression ISO captax results in increased expression of IL7R mRNA CTD PMID:20713136 NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Mir146a microRNA 146a increases expression ISO captax results in increased expression of MIR146A mRNA CTD PMID:37326882 NCBI chr10:28,349,996...28,350,090
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO captax results in increased expression of MMP9 mRNA; captax results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO captax results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects expression ISO captax affects the expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Notch3 notch receptor 3 decreases expression ISO captax results in decreased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:11,783,550...11,834,585
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO captax results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO captax results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO captax results in increased expression of RGS1 mRNA CTD PMID:20713136 NCBI chr13:58,568,844...58,573,187
Ensembl chr13:56,018,554...56,022,984 		JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO captax results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:61,988,350...62,095,542
Ensembl chr14:57,775,501...57,882,644 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO captax results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO captax results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO captax results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:100,272,729...100,586,364
Ensembl chr 6:94,537,088...94,848,064 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO captax results in decreased expression of TNF mRNA CTD PMID:20385217 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO captax results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tpo thyroid peroxidase multiple interactions
decreases activity		 ISO
EXP		 captax binds to and results in decreased activity of TPO protein
captax results in decreased activity of TPO protein		 CTD PMID:23959146 PMID:26865668 PMID:26884060 PMID:31629072 NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO captax results in increased expression of TXNRD1 mRNA CTD PMID:23445166 PMID:24211530 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO captax results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
dibenzothiazol-2-yl disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO [dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein CTD PMID:12062936 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein CTD PMID:12062936 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        biochemical role 19566
          metabolite 19554
            1,3-benzothiazole-2-thiol 52
              dibenzothiazol-2-yl disulfide 2
              tyrphostin AG 825 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              chalcogen hydride 2599
                                sulfur hydride 2111
                                  hydrogen sulfide 2111
                                    thiol group 1992
                                      thiol 1992
                                        aryl thiol 330
                                          1,3-benzothiazole-2-thiol 52
                                            dibenzothiazol-2-yl disulfide 2
                                            tyrphostin AG 825 0
paths to the root