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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-methyl-N'-nitro-N-nitrosoguanidine
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Accession:CHEBI:21759 term browser browse the term
Definition:An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Synonyms:related_synonym: 1-Methyl-1-nitroso-3-nitroguanidine;   1-Methyl-3-nitro-1-nitrosoguanidine;   1-Nitroso-3-nitro-1-methylguanidine;   Formula=C2H5N5O3;   InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4);   InChIKey=VZUNGTLZRAYYDE-UHFFFAOYSA-N;   MNG;   MNNG;   Methylnitronitrosoguanidine;   N'-Nitro-N-nitroso-N-methylguanidine;   N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide;   N-Methyl-N-nitroso-N'-nitroguanidine;   N-Methyl-N-nitrosonitroguanidin;   SMILES=CN(N=O)C(=N)N[N+]([O-])=O
 alt_id: CHEBI:34872
 xref: Beilstein:1779490;   CAS:70-25-7;   KEGG:C14592
 xref_mesh: MESH:D008769


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N-methyl-N'-nitro-N-nitrosoguanidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA CTD PMID:19840844 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of ACOX2 mRNA CTD PMID:15120970 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ADAM10 mRNA CTD PMID:12634122 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Agt angiotensinogen multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of AGT mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AGT mRNA CTD PMID:19840844 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
increases localization		 ISO benzamide inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein]; phenanthridone inhibits the reaction [Methylnitronitrosoguanidine results in increased localization of AIFM1 protein] CTD PMID:15589979 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of AKT1 mRNA]		 CTD PMID:35103375 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases secretion EXP Methylnitronitrosoguanidine results in decreased secretion of ALB protein CTD PMID:15772367 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of ALDH1A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ALDH1A1 mRNA CTD PMID:19840844 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Methylnitronitrosoguanidine results in increased expression of ALPL mRNA CTD PMID:12634122 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of AMBP mRNA CTD PMID:12773770 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Anxa5 annexin A5 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ANXA5 mRNA CTD PMID:19840844 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects response to substance
multiple interactions
decreases expression		 ISO APAF1 protein affects the susceptibility to Methylnitronitrosoguanidine
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein]		 CTD PMID:16019050 PMID:20434464 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression ISO Methylnitronitrosoguanidine results in increased expression of APC mRNA CTD PMID:12634122 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of APP mRNA CTD PMID:19840844 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of ARAF mRNA CTD PMID:12634122 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073 		JBrowse link
G Atm ATM serine/threonine kinase increases response to substance ISO ATM gene mutant form results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:15010311 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of ATP1B3 mRNA CTD PMID:12634122 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein] CTD PMID:26921499 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of AXL mRNA CTD PMID:12634122 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
multiple interactions
decreases phosphorylation		 ISO Methylnitronitrosoguanidine results in decreased expression of BAD mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAD mRNA]
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of BAD protein]		 CTD PMID:17828454 PMID:20434464 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bag1 BAG cochaperone 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of BAG1 mRNA CTD PMID:12634122 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO BAK1 protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib] CTD PMID:18376143 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression		 EXP
ISO		 [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BAX protein; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
BAX protein results in increased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BAX protein]
Methylnitronitrosoguanidine results in decreased expression of BAX mRNA; Methylnitronitrosoguanidine results in decreased expression of BAX protein		 CTD PMID:16030430 PMID:18376143 PMID:20434464 PMID:35103375 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BCAT2 mRNA CTD PMID:19840844 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases expression		 ISO
EXP		 Methylnitronitrosoguanidine results in decreased expression of BCL2 protein
[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]; Lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in increased expression of BCL2 protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2 protein]
Methylnitronitrosoguanidine results in increased expression of BCL2 mRNA; Methylnitronitrosoguanidine results in increased expression of BCL2 protein		 CTD PMID:16019050 PMID:16030430 PMID:20434464 PMID:35103375 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO BCL2L1 protein results in decreased susceptibility to [Methylnitronitrosoguanidine co-treated with veliparib]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BCL2L1 mRNA]		 CTD PMID:18376143 PMID:20434464 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions EXP [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of BCL2L11 protein] CTD PMID:16030430 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP Methylnitronitrosoguanidine results in increased expression of BDNF mRNA CTD PMID:15120970 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bgn biglycan multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of BGN mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of BGN mRNA CTD PMID:19840844 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
decreases expression		 ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of BID mRNA] CTD PMID:20434464 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of BIRC2 mRNA CTD PMID:12634122 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Blvrb biliverdin reductase B multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of BLVRB mRNA CTD PMID:19840844 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375 		JBrowse link
G Bmp4 bone morphogenetic protein 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of BMP4 mRNA CTD PMID:12773770 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Methylnitronitrosoguanidine results in increased expression of BRCA1 mRNA CTD PMID:12634122 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated increases expression ISO Methylnitronitrosoguanidine results in increased expression of BRCA2 mRNA CTD PMID:12634122 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Bsg basigin (Ok blood group) multiple interactions
increases expression		 EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of BSG mRNA] CTD PMID:35103375 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of BTG2 protein CTD PMID:24821435 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G C1qb complement C1q B chain increases expression EXP Methylnitronitrosoguanidine results in increased expression of C1QB mRNA CTD PMID:15120970 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1s complement C1s increases expression EXP Methylnitronitrosoguanidine results in increased expression of C1S mRNA CTD PMID:15120970 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CALM1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CALM1 mRNA CTD PMID:19840844 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
decreases expression		 ISO
EXP		 Methylnitronitrosoguanidine results in increased activity of CASP3 protein
[Methylnitronitrosoguanidine co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in increased activity of CASP3 protein; [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein; [S-allylcysteine co-treated with Lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP3 protein]; corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP3 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Methylnitronitrosoguanidine results in increased activity of CASP3 protein]
Methylnitronitrosoguanidine results in decreased expression of CASP3 mRNA; Methylnitronitrosoguanidine results in decreased expression of CASP3 protein		 CTD PMID:15589979 PMID:16019050 PMID:16030430 PMID:17428624 PMID:20434464 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CASP4 mRNA CTD PMID:12634122 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP [Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein; [S-allylcysteine co-treated with lycopene] inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; lycopene inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein]; S-allylcysteine inhibits the reaction [[Methylnitronitrosoguanidine co-treated with Sodium Chloride] results in decreased expression of CASP8 protein] CTD PMID:16030430 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
decreases expression		 ISO
EXP		 Methylnitronitrosoguanidine results in increased activity of CASP9 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CASP9 protein]		 CTD PMID:15589979 PMID:16019050 PMID:20434464 PMID:35103375 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in decreased activity of CAT protein] CTD PMID:35103375 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbx5 chromobox 5 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CBX5 mRNA CTD PMID:12634122 NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CCNA1 mRNA CTD PMID:12634122 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
decreases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNA
Methylnitronitrosoguanidine results in decreased expression of CCNB1 mRNA		 CTD PMID:11516527 PMID:12135628 PMID:19851710 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA]
Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA; Methylnitronitrosoguanidine results in increased expression of CCND1 protein
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCND1 protein		 CTD PMID:12135628 PMID:19851710 PMID:21628965 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CCNG1 mRNA CTD PMID:11516527 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Ccnh cyclin H increases expression ISO Methylnitronitrosoguanidine results in increased expression of CCNH mRNA CTD PMID:12634122 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCT2 mRNA CTD PMID:19840844 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944 		JBrowse link
G Cd59b CD59b molecule increases mutagenesis ISO Methylnitronitrosoguanidine results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cd9 CD9 molecule multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CD9 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD9 mRNA CTD PMID:19840844 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression		 EXP geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDH1 protein] CTD PMID:28428697 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh8 cadherin 8 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CDH8 mRNA CTD PMID:12634122 NCBI chr19:5,494,038...5,901,810
Ensembl chr19:5,494,174...5,895,669 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression
multiple interactions		 EXP
ISO		 Methylnitronitrosoguanidine results in increased expression of CDK4 protein
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CDK4 protein		 CTD PMID:12135628 PMID:21628965 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CDK5 mRNA CTD PMID:12634122 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
multiple interactions		 ISO
EXP		 Methylnitronitrosoguanidine results in decreased expression of CDKN1A mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1A protein]		 CTD PMID:12634122 PMID:19851710 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression
increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA
Methylnitronitrosoguanidine results in increased expression of CDKN1B protein
Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDKN1B protein]; Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA]		 CTD PMID:11516527 PMID:12135628 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cep43 centrosomal protein 43 increases expression ISO Methylnitronitrosoguanidine results in increased expression of CEP43 mRNA CTD PMID:12634122 NCBI chr 1:52,533,418...52,564,025
Ensembl chr 1:52,533,428...52,563,923 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein] CTD PMID:26921499 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein] CTD PMID:26921499 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ckb creatine kinase B decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CKB mRNA CTD PMID:12634122 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Clta clathrin, light chain A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CLTA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CLTA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CLTA mRNA CTD PMID:19840844 NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL1A2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL1A2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL1A2 mRNA CTD PMID:19840844 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL6A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL6A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL6A1 mRNA CTD PMID:19840844 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Col8a1 collagen type VIII alpha 1 chain multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL8A1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL8A1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL8A1 mRNA CTD PMID:19840844 NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of COX6A1 mRNA CTD PMID:19840844 NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041 		JBrowse link
G Cox8a cytochrome c oxidase subunit 8A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of COX8A mRNA CTD PMID:19840844 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression		 EXP geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CTNNB1 mRNA] CTD PMID:28428697 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of CTSB mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of CTSB mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CTSB mRNA CTD PMID:19840844 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CTSL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CTSL mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CTSL mRNA CTD PMID:19840844 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CXCL12 mRNA CTD PMID:19840844 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CXCR4 mRNA CTD PMID:12634122 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyb561d2 cytochrome b561 family, member D2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of CYB561D2 mRNA CTD PMID:12634122 NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
decreases expression		 ISO Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of CYCS protein]
Methylnitronitrosoguanidine results in decreased expression of CYCS mRNA; Methylnitronitrosoguanidine results in decreased expression of CYCS protein		 CTD PMID:20434464 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of DAB2 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dcn decorin decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of DCN mRNA CTD PMID:15120970 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of DEAF1 mRNA CTD PMID:12634122 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Dek DEK proto-oncogene increases expression ISO Methylnitronitrosoguanidine results in increased expression of DEK mRNA CTD PMID:12634122 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of DLG1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of DLG1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DLG1 mRNA CTD PMID:19840844 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dstn destrin, actin depolymerizing factor increases expression ISO Methylnitronitrosoguanidine results in increased expression of DSTN mRNA CTD PMID:12634122 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379 		JBrowse link
G Dut deoxyuridine triphosphatase affects localization
increases secretion		 ISO Methylnitronitrosoguanidine affects the localization of DUT protein
Methylnitronitrosoguanidine results in increased secretion of DUT protein		 CTD PMID:21658424 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of E2F1 protein
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F1 protein]; E2F1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein results in increased expression of RRM2 mRNA]		 CTD PMID:26921499 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f3 E2F transcription factor 3 multiple interactions ISO [[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; [Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; CHIR-124 inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of E2F3 protein]; E2F3 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]] CTD PMID:26921499 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253 		JBrowse link
G Egf epidermal growth factor affects activity
multiple interactions		 ISO Methylnitronitrosoguanidine affects the activity of EGF protein
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]; Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]		 CTD PMID:15708576 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor affects localization
multiple interactions		 ISO Methylnitronitrosoguanidine affects the localization of EGFR protein
Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]		 CTD PMID:15708576 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EGR1 mRNA CTD PMID:19840844 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF1 mRNA CTD PMID:19840844 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 		JBrowse link
G Eif3e eukaryotic translation initiation factor 3 subunit E increases expression ISO Methylnitronitrosoguanidine results in increased expression of EIF3E mRNA CTD PMID:12634122 NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of EIF5 mRNA CTD PMID:12634122 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EIF5A mRNA CTD PMID:19840844 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Elk3 ETS transcription factor ELK3 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ELK3 mRNA CTD PMID:12634122 NCBI chr 7:27,768,582...27,831,088
Ensembl chr 7:27,768,599...27,804,084 		JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of EMP1 mRNA CTD PMID:12634122 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of ENPP2 mRNA CTD PMID:15120970 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Epcam epithelial cell adhesion molecule increases expression ISO Methylnitronitrosoguanidine results in increased expression of EPCAM mRNA CTD PMID:12634122 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Epha1 Eph receptor A1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of EPHA1 mRNA CTD PMID:12634122 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846 		JBrowse link
G Ephb3 Eph receptor B3 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of EPHB3 mRNA CTD PMID:12634122 NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370 		JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of EPS8 mRNA CTD PMID:19840844 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ERBB2 mRNA CTD PMID:12634122 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of ERBB4 mRNA CTD PMID:12634122 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of ESR2 mRNA; Methylnitronitrosoguanidine results in increased expression of ESR2 protein CTD PMID:21628965 PMID:22330348 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO Methylnitronitrosoguanidine results in increased expression of ETS1 mRNA CTD PMID:12634122 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010 		JBrowse link
G Faslg Fas ligand decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of FASLG protein CTD PMID:24821435 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Methylnitronitrosoguanidine results in increased expression of FASN mRNA CTD PMID:12634122 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fau FAU ubiquitin like and ribosomal protein S30 fusion multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of FAU mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of FAU mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FAU mRNA CTD PMID:19840844 NCBI chr 1:203,350,226...203,351,741
Ensembl chr 1:203,350,189...203,351,742 		JBrowse link
G Fcer1a Fc epsilon receptor Ia increases expression EXP Methylnitronitrosoguanidine results in increased expression of FCER1A mRNA CTD PMID:15120970 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Fcgr2a Fc gamma receptor 2A increases expression EXP Methylnitronitrosoguanidine results in increased expression of FCGR3 mRNA CTD PMID:15120970 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgrt Fc gamma receptor and transporter decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of FCGRT mRNA CTD PMID:12634122 NCBI chr 1:95,574,436...95,584,171
Ensembl chr 1:95,567,175...95,584,084 		JBrowse link
G Fes FES proto-oncogene, tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of FES mRNA CTD PMID:12634122 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934 		JBrowse link
G Fgf10 fibroblast growth factor 10 increases expression EXP Methylnitronitrosoguanidine results in increased expression of FGF10 mRNA CTD PMID:15120970 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases expression		 EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA] CTD PMID:20434464 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Folr1 folate receptor alpha increases methylation ISO Methylnitronitrosoguanidine results in increased methylation of FOLR1 promoter CTD PMID:29644877 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in decreased expression of FOSL1 mRNA
Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein results in increased expression of RRM2 mRNA]		 CTD PMID:12634122 PMID:26921499 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fst follistatin increases expression EXP Methylnitronitrosoguanidine results in increased expression of FST mRNA CTD PMID:15120970 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571 		JBrowse link
G Fstl1 follistatin-like 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of FSTL1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of FSTL1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FSTL1 mRNA CTD PMID:19840844 NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of FYN mRNA CTD PMID:12634122 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of GADD45A mRNA]		 CTD PMID:19851710 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gcgr glucagon receptor decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of GCGR mRNA CTD PMID:15120970 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Methylnitronitrosoguanidine results in increased expression of GDF15 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GJA1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GJA1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GJA1 mRNA CTD PMID:19840844 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb2 gap junction protein, beta 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of GJB2 mRNA CTD PMID:15120970 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177 		JBrowse link
G Gli1 GLI family zinc finger 1 increases expression EXP MNNG increases expression of Gli1 mRNA in rat stomach RGD PMID:30537251 RGD:150520178 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gpc4 glypican 4 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GPC4 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GPC4 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GPC4 mRNA CTD PMID:19840844 NCBI chr  X:131,644,711...131,755,349
Ensembl chr  X:131,644,704...131,755,284 		JBrowse link
G Gss glutathione synthetase decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of GSS mRNA CTD PMID:12634122 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GSTM2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GSTM2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GSTM2 mRNA CTD PMID:19840844 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTO1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTO1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTO1 mRNA CTD PMID:19840844 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTP1 mRNA CTD PMID:19840844 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gtf2i general transcription factor II I multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [GTF2I protein binds to RRM2 promoter] CTD PMID:26921499 NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form
[[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; E2F3 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; RRM2 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]		 CTD PMID:26921499 PMID:27233451 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of H4C2 mRNA CTD PMID:12634122 NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048 		JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 increases expression EXP Methylnitronitrosoguanidine results in increased expression of HBA1 mRNA CTD PMID:15120970 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HIF1A mRNA]		 CTD PMID:35103375 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions		 ISO
EXP		 Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA]		 CTD PMID:12634122 PMID:35103375 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgb2 high mobility group box 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of HMGB2 mRNA CTD PMID:12634122 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of HPGD mRNA CTD PMID:15120970 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HPRT1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of HPRT1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HPRT1 mRNA CTD PMID:19840844 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein] CTD PMID:15708576 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AA1 mRNA CTD PMID:19840844 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSP90AB1 mRNA CTD PMID:19840844 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of HSP90B1 mRNA CTD PMID:12634122 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of HSPA1A mRNA CTD PMID:15120970 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of HSPD1 mRNA CTD PMID:19840844 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases response to substance
increases expression
multiple interactions		 ISO ICAM1 protein results in decreased susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in increased expression of ICAM1 mRNA; Methylnitronitrosoguanidine results in increased expression of ICAM1 protein
prolinedithiocarbamate inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of ICAM1 protein]		 CTD PMID:22001597 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of ID1 mRNA CTD PMID:12634122 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IER3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IER3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IER3 mRNA CTD PMID:19840844 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of IFITM1 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of IFRD1 mRNA CTD PMID:12634122 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igkc immunoglobulin kappa constant increases expression EXP Methylnitronitrosoguanidine results in increased expression of IGKC mRNA CTD PMID:15120970
G Igsf6 immunoglobulin superfamily, member 6 increases expression EXP Methylnitronitrosoguanidine results in increased expression of IGSF6 mRNA CTD PMID:15120970 NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
increases expression		 EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of IKBKB protein] CTD PMID:19851710 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of IRAK1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of IRAK1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IRAK1 mRNA CTD PMID:19840844 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of ITGB4 mRNA CTD PMID:12634122 PMID:12773770 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of JMJD6 mRNA CTD PMID:19840844 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182 		JBrowse link
G Jpt1 Jupiter microtubule associated homolog 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of JPT1 mRNA CTD PMID:19840844 NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 increases expression EXP Methylnitronitrosoguanidine results in increased expression of KCTD12 mRNA CTD PMID:15120970 NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282 		JBrowse link
G Kdm8 lysine demethylase 8 multiple interactions ISO Methylnitronitrosoguanidine inhibits the reaction [TP53 protein binds to KDM8 protein] CTD PMID:26025680 NCBI chr 1:180,013,969...180,028,829
Ensembl chr 1:180,020,656...180,028,841 		JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of KIT mRNA CTD PMID:12634122 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652 		JBrowse link
G Kitlg KIT ligand decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of KITLG mRNA CTD PMID:15120970 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Klf10 KLF transcription factor 10 decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of KLF10 mRNA CTD PMID:15120970 NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases expression		 EXP geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of KRAS mRNA] CTD PMID:28428697 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt17 keratin 17 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of KRT17 mRNA CTD PMID:12634122 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 EXP corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of LDHA mRNA] CTD PMID:35103375 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Lgals3 galectin 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LGALS3 mRNA CTD PMID:19840844 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lgals8 galectin 8 increases expression ISO Methylnitronitrosoguanidine results in increased expression of LGALS8 mRNA CTD PMID:12634122 NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of LIG1 mRNA CTD PMID:12634122 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lipa lipase A, lysosomal acid type increases expression EXP Methylnitronitrosoguanidine results in increased expression of LIP1 mRNA CTD PMID:15120970 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633 		JBrowse link
G Lox lysyl oxidase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LOX mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LOX mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LOX mRNA CTD PMID:19840844 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of LPL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of LPL mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LPL mRNA CTD PMID:19840844 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MAP2K1 mRNA]		 CTD PMID:28428697 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MAP3K12 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MAP3K12 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MAP3K12 mRNA CTD PMID:19840844 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK1 protein]] CTD PMID:17828454 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Methylnitronitrosoguanidine results in increased phosphorylation of MAPK14 protein CTD PMID:22001597 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased phosphorylation of MAPK3 protein]] CTD PMID:17828454 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk4 mitogen-activated protein kinase 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MAPK4 mRNA CTD PMID:12634122 NCBI chr18:67,512,805...67,661,271
Ensembl chr18:67,512,807...67,661,842 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Methylnitronitrosoguanidine results in increased phosphorylation of MAPK8 protein CTD PMID:22001597 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MAPK9 mRNA CTD PMID:12634122 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of MARCKS mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of MARCKS mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MARCKS mRNA CTD PMID:19840844 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Max MYC associated factor X increases expression ISO Methylnitronitrosoguanidine results in increased expression of MAX mRNA CTD PMID:12634122 NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:95,636,858...95,662,137 		JBrowse link
G Mcam melanoma cell adhesion molecule increases expression ISO Methylnitronitrosoguanidine results in increased expression of MCAM mRNA CTD PMID:12634122 PMID:12773770 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in decreased expression of MCM2 mRNA
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM2 mRNA		 CTD PMID:12634122 PMID:19840844 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847 		JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MCM4 mRNA CTD PMID:12634122 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of MCM6 mRNA CTD PMID:19840844 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of MDM2 mRNA
Methylnitronitrosoguanidine results in increased expression of MDM2 protein
Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MDM2 protein]		 CTD PMID:12135628 PMID:12634122 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mecom MDS1 and EVI1 complex locus increases expression ISO Methylnitronitrosoguanidine results in increased expression of MECOM mRNA CTD PMID:12634122 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Methylnitronitrosoguanidine results in increased expression of MET mRNA CTD PMID:12634122 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:1727384 PMID:15010311 PMID:16043385 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MGST2 mRNA CTD PMID:12634122 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MGST3 mRNA CTD PMID:19840844 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Mir21 microRNA 21 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MIR21 mRNA CTD PMID:24821435 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MLH1 protein CTD PMID:17671175 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP2 mRNA]; Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP2 protein
[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of MMP2 mRNA		 CTD PMID:19840844 PMID:20434464 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of MMP9 mRNA]; Methylnitronitrosoguanidine results in increased expression of and results in increased activity of MMP9 protein CTD PMID:20434464 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases response to substance ISO MPG protein results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:15299078 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mpp1 MAGUK p55 scaffold protein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of MPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of MPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MPP1 mRNA CTD PMID:19840844
G Msh2 mutS homolog 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MSH2 mRNA CTD PMID:12634122 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mst1 macrophage stimulating 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of MST1 mRNA CTD PMID:15120970 NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases methylation ISO Methylnitronitrosoguanidine results in increased methylation of MTHFR promoter CTD PMID:29644877 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mutyh mutY DNA glycosylase multiple interactions ISO MUTYH protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PARP1 protein] CTD PMID:26954031 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MYBL1 mRNA CTD PMID:12634122 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of MYC protein
Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of MYC protein]		 CTD PMID:12135628 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myl2 myosin light chain 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MYL2 mRNA CTD PMID:12634122 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Myl9 myosin light chain 9 increases expression ISO Methylnitronitrosoguanidine results in increased expression of MYL9 mRNA CTD PMID:12634122 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk myosin light chain kinase decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of MYLK mRNA CTD PMID:12634122 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of NBL1 mRNA CTD PMID:12634122 NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKB1 protein]
Methylnitronitrosoguanidine results in increased expression of NFKB1 mRNA; Methylnitronitrosoguanidine results in increased expression of NFKB1 protein		 CTD PMID:19851710 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
increases expression		 EXP
ISO		 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]
Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA; Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein
Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased degradation of NFKBIA protein		 CTD PMID:19851710 PMID:22001597 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfya nuclear transcription factor Y subunit alpha multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [NFYA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [NFYB protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein] CTD PMID:26921499 NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565 		JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [NFYC protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377 		JBrowse link
G Nrp1 neuropilin 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of NRP1 mRNA CTD PMID:15120970 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ODC1 mRNA CTD PMID:19840844 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PA2G4 mRNA CTD PMID:19840844 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331 		JBrowse link
G Parg poly (ADP-ribose) glycohydrolase multiple interactions
affects response to substance		 ISO [Hydrolyzable Tannins results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; [nobotanin B results in decreased activity of PARG protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; benzamide inhibits the reaction [PARG affects the susceptibility to Methylnitronitrosoguanidine] CTD PMID:11593040 PMID:15591342 NCBI chr16:7,436,429...7,544,276
Ensembl chr16:7,436,476...7,544,273 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity
affects cleavage
increases response to substance
increases expression		 ISO [benzamide results in decreased activity of PARP1 protein] which results in decreased susceptibility to Methylnitronitrosoguanidine; [Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD; benzamide inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; Eugenol affects the reaction [Methylnitronitrosoguanidine affects the cleavage of PARP1 protein]; Hydrolyzable Tannins inhibits the reaction [[Methylnitronitrosoguanidine results in increased activity of PARP1 protein] which results in decreased abundance of NAD]; MUTYH protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PARP1 protein]
PARP1 protein results in increased susceptibility to Methylnitronitrosoguanidine		 CTD PMID:11593040 PMID:20434464 PMID:22001597 PMID:26954031 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PCBP2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PCBP2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCBP2 mRNA CTD PMID:19840844 NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863 		JBrowse link
G Pcdh7 protocadherin 7 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PCDH7 mRNA CTD PMID:12634122 NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions
increases expression		 ISO
EXP		 Methylnitronitrosoguanidine results in decreased expression of PCNA mRNA
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]; geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PCNA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PCNA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PCNA mRNA; Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PCNA mRNA]; Cadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in increased expression of PCNA protein]
Methylnitronitrosoguanidine results in increased expression of PCNA mRNA; Methylnitronitrosoguanidine results in increased expression of PCNA protein		 CTD PMID:11516527 PMID:12135628 PMID:12634122 PMID:19840844 PMID:19851710 More... NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO Methylnitronitrosoguanidine results in increased expression of PDGFB mRNA CTD PMID:12634122 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PDGFRA mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PDGFRA mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PDGFRA mRNA CTD PMID:19840844 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PDIA3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PDIA3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDIA3 mRNA CTD PMID:19840844 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PEA15 mRNA CTD PMID:12634122 NCBI chr13:84,657,815...84,667,437
Ensembl chr13:84,654,870...84,667,499 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PGK1 mRNA CTD PMID:12634122 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pgr progesterone receptor decreases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in decreased expression of PGR protein
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PGR protein]		 CTD PMID:28428697 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3CG mRNA]		 CTD PMID:35103375 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of PIK3R1 mRNA]		 CTD PMID:28428697 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plxna3 plexin A3 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PLXNA3 mRNA CTD PMID:12634122 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Podxl podocalyxin-like multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PODXL mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PODXL mRNA CTD PMID:19840844 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Postn periostin decreases expression EXP Methylnitronitrosoguanidine results in decreased expression of POSTN mRNA CTD PMID:15120970 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha decreases response to substance ISO PPP2R2A protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:25772433 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma increases response to substance ISO PPP2R5C protein results in increased susceptibility to Methylnitronitrosoguanidine CTD PMID:25772433 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon decreases response to substance ISO PPP2R5E protein results in decreased susceptibility to Methylnitronitrosoguanidine CTD PMID:25772433 NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872 		JBrowse link
G Prkd1 protein kinase D1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PRKD1 mRNA CTD PMID:12634122 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Pten phosphatase and tensin homolog decreases response to substance
decreases expression
multiple interactions		 ISO
EXP		 PTEN protein results in decreased susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in decreased expression of PTEN protein
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PTEN protein]		 CTD PMID:20530668 PMID:28428697 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptn pleiotrophin multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PTN mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PTN mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTN mRNA CTD PMID:19840844 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of PTP4A1 mRNA CTD PMID:12634122 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PTPRA mRNA CTD PMID:12634122 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728 		JBrowse link
G Ptprg protein tyrosine phosphatase, receptor type, G decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PTPRG mRNA CTD PMID:12634122 NCBI chr15:12,871,706...13,552,186
Ensembl chr15:12,871,721...13,554,094 		JBrowse link
G Ptprs protein tyrosine phosphatase, receptor type, S decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of PTPRS mRNA CTD PMID:12634122 NCBI chr 9:1,245,408...1,307,015
Ensembl chr 9:1,245,410...1,306,947 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PTTG1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PTTG1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTTG1 mRNA CTD PMID:19840844 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837 		JBrowse link
G Pura purine rich element binding protein A multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [PURA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [PURA protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr18:27,885,071...27,905,509
Ensembl chr18:27,884,556...27,905,513 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RACGAP1 mRNA CTD PMID:19840844 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831 		JBrowse link
G Rad21 RAD21 cohesin complex component multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RAD21 mRNA CTD PMID:19840844 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of RAD23A mRNA CTD PMID:12634122 PMID:12773770 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit increases expression ISO Methylnitronitrosoguanidine results in increased expression of RBBP5 mRNA CTD PMID:12634122 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107 		JBrowse link
G Rbm6 RNA binding motif protein 6 increases expression ISO Methylnitronitrosoguanidine results in increased expression of RBM6 mRNA CTD PMID:12634122 NCBI chr 8:108,452,687...108,552,783
Ensembl chr 8:108,452,687...108,552,771 		JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs multiple interactions
decreases expression		 EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein]
Methylnitronitrosoguanidine results in decreased expression of RECK mRNA; Methylnitronitrosoguanidine results in decreased expression of RECK protein		 CTD PMID:20434464 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 EXP Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RELA protein]
Methylnitronitrosoguanidine results in increased expression of RELA mRNA; Methylnitronitrosoguanidine results in increased expression of RELA protein		 CTD PMID:19851710 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Reln reelin increases expression EXP Methylnitronitrosoguanidine results in increased expression of RELN mRNA CTD PMID:15120970 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rgs18 regulator of G-protein signaling 18 increases expression EXP Methylnitronitrosoguanidine results in increased expression of RGS18 mRNA CTD PMID:15120970 NCBI chr13:56,493,134...56,516,045
Ensembl chr13:56,494,010...56,516,098 		JBrowse link
G Ros1 ROS proto-oncogene 1 , receptor tyrosine kinase increases expression EXP Methylnitronitrosoguanidine results in increased expression of ROS1 mRNA CTD PMID:15120970 NCBI chr20:31,432,636...31,583,998
Ensembl chr20:31,432,637...31,583,865 		JBrowse link
G Rpl7 ribosomal protein L7 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of RPL7 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RPL7 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of RPL7 mRNA CTD PMID:19840844 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rps11 ribosomal protein S11 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of RPS11 mRNA CTD PMID:19840844 NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874 		JBrowse link
G Rps20 ribosomal protein S20 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of RPS20 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of RPS20 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of RPS20 mRNA CTD PMID:19840844 NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475 		JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Methylnitronitrosoguanidine results in increased expression of RPSA mRNA CTD PMID:12773770 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA
[[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]; [Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; CHEK1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; CHIR-124 inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [[FOSL1 protein binds to JUNB protein] which results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [DP1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [DP1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [FOSL1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [GTF2I protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [IFI16 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [IFI16 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYA protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYB protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [NFYC protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [PURA protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [PURA protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine promotes the reaction [YY1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [YY1 protein results in increased expression of RRM2 mRNA]; Methylnitronitrosoguanidine results in increased expression of and affects the localization of RRM2 protein; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein binds to RRM2 promoter]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine promotes the reaction [E2F3 protein results in increased expression of RRM2 mRNA]]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 mRNA]; NFYB protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2 protein]; RRM2 protein inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form]		 CTD PMID:26921499 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression
affects expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA
Methylnitronitrosoguanidine affects the expression of RRM2B mRNA
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]; E2F1 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; E2F3 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B mRNA]; Methylnitronitrosoguanidine results in increased expression of and affects the localization of RRM2B protein; TP53 protein mutant form inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]		 CTD PMID:21704725 PMID:26921499 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of HLA-DRB1 mRNA CTD PMID:12634122 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [RUVBL1 protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 4:120,932,486...120,967,400
Ensembl chr 4:120,932,417...121,029,384 		JBrowse link
G Sec61g Sec61 translocon subunit gamma multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SEC61G mRNA CTD PMID:19840844 NCBI chr14:90,899,766...90,906,143
Ensembl chr14:90,899,768...90,906,162 		JBrowse link
G Selenop selenoprotein P multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of SELENOP mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of SELENOP mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SELENOP mRNA CTD PMID:19840844 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Methylnitronitrosoguanidine results in increased expression of SERPINE1 mRNA CTD PMID:15120970 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serping1 serpin family G member 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of SERPING1 mRNA CTD PMID:12634122 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Slc16a3 solute carrier family 16 member 3 increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA
corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of SLC16A3 mRNA]		 CTD PMID:35103375 NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562 		JBrowse link
G Smad2 SMAD family member 2 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of SMAD2 mRNA CTD PMID:12634122 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression EXP MNNG increases expression of Smo mRNA in rat stomach RGD PMID:30537251 RGD:150520178 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Snora62 small nucleolar RNA, H/ACA box 62 increases expression ISO Methylnitronitrosoguanidine results in increased expression of SNORA62 mRNA CTD PMID:12773770 NCBI chr 8:119,853,958...119,854,106
Ensembl chr 8:119,853,958...119,854,106 		JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N increases expression ISO Methylnitronitrosoguanidine results in increased expression of SNRPN mRNA CTD PMID:12634122 NCBI chr 1:111,101,327...111,123,400
Ensembl chr 1:111,101,329...111,123,634 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of SPARC mRNA CTD PMID:12634122 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of SPINK1 mRNA CTD PMID:12634122 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Spint2 serine peptidase inhibitor, Kunitz type, 2 decreases expression
increases expression		 ISO Methylnitronitrosoguanidine results in decreased expression of SPINT2 mRNA
Methylnitronitrosoguanidine results in increased expression of SPINT2 mRNA		 CTD PMID:12634122 NCBI chr 1:84,558,159...84,580,616
Ensembl chr 1:84,558,166...84,580,616 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SPP1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SPP1 mRNA CTD PMID:19840844 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqle squalene epoxidase increases expression
multiple interactions		 ISO Methylnitronitrosoguanidine results in increased expression of SQLE mRNA
[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SQLE mRNA		 CTD PMID:12634122 PMID:19840844 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of SRSF7 mRNA CTD PMID:12634122 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965 		JBrowse link
G Stk39 serine threonine kinase 39 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of STK39 mRNA CTD PMID:12634122 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling decreases expression EXP MNNG decreases expression of Sufu mRNA in rat stomach RGD PMID:30537251 RGD:150520178 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SUMO2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SUMO2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SUMO2 mRNA CTD PMID:19840844 NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513 		JBrowse link
G Syn1 synapsin I multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of SYN1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of SYN1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of SYN1 mRNA CTD PMID:19840844 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Tbrg4 transforming growth factor beta regulator 4 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TBRG4 mRNA CTD PMID:12634122 NCBI chr14:81,481,977...81,490,781
Ensembl chr14:81,481,981...81,490,756 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 EXP Methylnitronitrosoguanidine results in increased expression of TGFB1 mRNA
geraniol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TGFB1 mRNA]		 CTD PMID:28428697 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS1 mRNA CTD PMID:19840844 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Thbs2 thrombospondin 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of THBS2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of THBS2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA CTD PMID:19840844 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TIAM1 mRNA CTD PMID:12634122 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions		 EXP
ISO		 Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA; Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 mRNA]; Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TIMP2 protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TIMP2 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TIMP2 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TIMP2 mRNA		 CTD PMID:19840844 PMID:20434464 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression EXP Methylnitronitrosoguanidine results in increased expression of TLR4 mRNA CTD PMID:15120970 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TMSB4X mRNA CTD PMID:19840844 NCBI chr  X:27,144,666...27,146,667
Ensembl chr  X:27,128,610...27,146,667 		JBrowse link
G Tnc tenascin C increases expression ISO Methylnitronitrosoguanidine results in increased expression of TNC mRNA CTD PMID:12634122 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnfrsf25 TNF receptor superfamily member 25 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TNFRSF25 mRNA CTD PMID:12634122 NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TOP2A mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TOP2A mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TOP2A mRNA CTD PMID:19840844 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases response to substance
increases response to substance
increases acetylation
multiple interactions
decreases expression		 ISO
EXP		 Methylnitronitrosoguanidine results in increased expression of TP53 mRNA; Methylnitronitrosoguanidine results in increased expression of TP53 protein
TP53 protein mutant form results in decreased susceptibility to Methylnitronitrosoguanidine
TP53 protein results in increased susceptibility to Methylnitronitrosoguanidine
Methylnitronitrosoguanidine results in increased acetylation of TP53 protein
Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of TP53 protein]; resveratrol inhibits the reaction [Methylnitronitrosoguanidine results in increased acetylation of TP53 protein]
[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TRP53 mRNA; Cadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of TRP53 protein]
ATR protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]; CHEK2 protein promotes the reaction [Methylnitronitrosoguanidine results in increased expression of TP53 protein]; Methylnitronitrosoguanidine inhibits the reaction [TP53 protein binds to KDM8 protein]; TP53 protein mutant form inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of RRM2B protein]		 CTD PMID:9667752 PMID:11516527 PMID:12135628 PMID:12634122 PMID:15589979 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tram1 translocation associated membrane protein 1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of TRAM1 mRNA CTD PMID:12634122 NCBI chr 5:5,642,579...5,667,666
Ensembl chr 5:5,642,546...5,686,971 		JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of TSC22D1 mRNA CTD PMID:12634122 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958 		JBrowse link
G Ttc3 tetratricopeptide repeat domain 3 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of TTC3 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of TTC3 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of TTC3 mRNA CTD PMID:19840844 NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TXN1 mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of TXN1 mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of TXN1 mRNA CTD PMID:19840844 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of UBC mRNA; [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of UBC mRNA; [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of UBC mRNA CTD PMID:19840844 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression ISO Methylnitronitrosoguanidine results in increased expression of UCHL1 mRNA CTD PMID:12634122 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of UCP2 mRNA CTD PMID:19840844 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vim vimentin increases expression ISO Methylnitronitrosoguanidine results in increased expression of VIM mRNA CTD PMID:12634122 PMID:12773770 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 decreases expression ISO Methylnitronitrosoguanidine results in decreased expression of WARS1 mRNA CTD PMID:12634122 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO Methylnitronitrosoguanidine results in increased expression of WNT2 mRNA CTD PMID:12634122 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402 		JBrowse link
G Yy1 YY1 transcription factor multiple interactions ISO Methylnitronitrosoguanidine promotes the reaction [YY1 protein binds to RRM2 promoter]; Methylnitronitrosoguanidine promotes the reaction [YY1 protein results in increased expression of RRM2 mRNA] CTD PMID:26921499 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19814
      chemical role 19449
        explosive 4720
          nitroguanidine 733
            N-methyl-N'-nitro-N-nitrosoguanidine 303
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            heteroorganic entity 19488
                              organonitrogen compound 18810
                                guanidines 2325
                                  guanidine 743
                                    nitroguanidine 733
                                      N-methyl-N'-nitro-N-nitrosoguanidine 303
paths to the root