Ptp4a1 (protein tyrosine phosphatase 4A1) - Rat Genome Database

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Gene: Ptp4a1 (protein tyrosine phosphatase 4A1) Rattus norvegicus
Analyze
Symbol: Ptp4a1
Name: protein tyrosine phosphatase 4A1
RGD ID: 61970
Description: Enables protein tyrosine phosphatase activity. Predicted to be involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100360241; LOC103693189; MGC93357; PRL-1; protein tyrosine phosphatase 4a1-like; protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA, member 1; protein-tyrosine phosphatase 4a1; protein-tyrosine phosphatase of regenerating liver 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ptp4a1-ps5  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: The loci 103693189 and 29463 are annotated independently on Rnor_6.0 (Annotation Release 105) assembly. [04 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8940,710,250 - 40,718,176 (-)NCBIGRCr8
mRatBN7.2933,214,201 - 33,245,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl933,214,208 - 33,221,964 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx941,706,932 - 41,714,858 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0946,838,082 - 46,846,016 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0945,119,940 - 45,127,874 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0937,223,363 - 37,254,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl937,223,729 - 37,231,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl93,896,337 - 3,899,315 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0936,028,286 - 36,059,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4929,617,636 - 29,625,197 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1929,618,696 - 29,626,440 (-)NCBI
Celera931,034,176 - 31,042,102 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
aldrin  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phytoestrogen  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
rimonabant  (ISO)
rotenone  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
triacsin C  (ISO)
trichloroethene  (EXP)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Diamond RH, etal., Mol Cell Biol 1994 Jun;14(6):3752-62.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8840018   PMID:10679780   PMID:10940933   PMID:12782572   PMID:15489334   PMID:15682487   PMID:16142898   PMID:17032584   PMID:23376485   PMID:34689832   PMID:35255961  


Genomics

Comparative Map Data
Ptp4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8940,710,250 - 40,718,176 (-)NCBIGRCr8
mRatBN7.2933,214,201 - 33,245,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl933,214,208 - 33,221,964 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx941,706,932 - 41,714,858 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0946,838,082 - 46,846,016 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0945,119,940 - 45,127,874 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0937,223,363 - 37,254,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl937,223,729 - 37,231,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl93,896,337 - 3,899,315 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0936,028,286 - 36,059,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4929,617,636 - 29,625,197 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1929,618,696 - 29,626,440 (-)NCBI
Celera931,034,176 - 31,042,102 (-)NCBICelera
Cytogenetic Map9q21NCBI
PTP4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38663,516,440 - 63,583,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl663,521,746 - 63,583,588 (+)EnsemblGRCh38hg38GRCh38
GRCh37664,226,345 - 64,293,493 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36664,339,879 - 64,351,448 (+)NCBINCBI36Build 36hg18NCBI36
Build 34664,340,378 - 64,351,244NCBI
Celera662,442,473 - 62,454,047 (+)NCBICelera
Cytogenetic Map6q12NCBI
HuRef661,461,747 - 61,473,329 (+)NCBIHuRef
CHM1_1664,448,190 - 64,459,766 (+)NCBICHM1_1
T2T-CHM13v2.0664,662,355 - 64,729,529 (+)NCBIT2T-CHM13v2.0
Ptp4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39130,979,384 - 30,988,838 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl130,979,383 - 30,988,851 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl130,979,383 - 30,988,390 (-)EnsemblGRCm39 Ensembl
GRCm38130,940,303 - 30,949,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl130,940,302 - 30,949,770 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl130,940,302 - 30,949,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv37130,997,148 - 31,006,600 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36130,886,135 - 30,894,291 (-)NCBIMGSCv36mm8
Celera130,745,276 - 30,754,732 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map111.47NCBI
Ptp4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955502322,105 - 329,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955502322,827 - 329,226 (-)NCBIChiLan1.0ChiLan1.0
PTP4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2578,439,210 - 78,443,766 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1673,099,104 - 73,105,570 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0661,257,780 - 61,269,097 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1666,529,894 - 66,541,665 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl666,530,382 - 66,541,672 (+)Ensemblpanpan1.1panPan2
PTP4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11227,044,470 - 27,053,181 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1227,044,533 - 27,052,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1226,953,087 - 26,961,741 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01227,579,933 - 27,588,608 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1227,579,753 - 27,622,432 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11227,084,459 - 27,093,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01227,166,923 - 27,175,589 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01227,264,042 - 27,272,715 (+)NCBIUU_Cfam_GSD_1.0
Ptp4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494662,514,567 - 62,524,902 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364761,435,295 - 1,441,142 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTP4A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl145,170,468 - 45,180,289 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1145,169,913 - 45,180,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2150,511,780 - 50,521,596 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTP4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11711,215,005 - 11,248,911 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605817,511,518 - 17,545,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptp4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475321,918,461 - 21,923,873 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475321,918,445 - 21,926,451 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptp4a1
120 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:135
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000016237
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat

Markers in Region
RH128958  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q21UniSTS
RH140279  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q21UniSTS
Ptp4a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X137,875,660 - 137,876,614 (-)MAPPERmRatBN7.2
Rnor_6.0965,085,524 - 65,086,268NCBIRnor6.0
Rnor_6.01372,154,591 - 72,155,544NCBIRnor6.0
Rnor_5.01377,096,527 - 77,097,480UniSTSRnor5.0
Rnor_5.0964,882,122 - 64,882,866UniSTSRnor5.0
RGSC_v3.4X145,027,098 - 145,028,051UniSTSRGSC3.4
RGSC_v3.4956,853,881 - 56,854,858UniSTSRGSC3.4
Celera957,179,170 - 57,180,147UniSTS
CeleraX133,964,534 - 133,965,487UniSTS
Cytogenetic Map9q21UniSTS
Cytogenetic Map13q21UniSTS
Cytogenetic Map9q31UniSTS
Cytogenetic MapXq36UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016237   ⟹   ENSRNOP00000016237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl933,214,208 - 33,221,964 (-)Ensembl
Rnor_6.0 Ensembl937,223,729 - 37,231,291 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079166   ⟹   ENSRNOP00000074101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl93,896,337 - 3,899,315 (+)Ensembl
RefSeq Acc Id: NM_031579   ⟹   NP_113767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8940,710,250 - 40,718,176 (-)NCBI
mRatBN7.2933,214,201 - 33,222,127 (-)NCBI
Rnor_6.0937,223,363 - 37,231,291 (-)NCBI
Rnor_5.0936,028,286 - 36,059,131 (-)NCBI
RGSC_v3.4929,617,636 - 29,625,197 (-)RGD
Celera931,034,176 - 31,042,102 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266813   ⟹   XP_063122883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8940,710,250 - 40,714,846 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113767   ⟸   NM_031579
- UniProtKB: Q4QRA5 (UniProtKB/Swiss-Prot),   Q8VH48 (UniProtKB/Swiss-Prot),   Q78EG7 (UniProtKB/Swiss-Prot),   A6IN79 (UniProtKB/TrEMBL),   A0A8I5Y1B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016237   ⟸   ENSRNOT00000016237
RefSeq Acc Id: ENSRNOP00000074101   ⟸   ENSRNOT00000079166
RefSeq Acc Id: XP_063122883   ⟸   XM_063266813
- Peptide Label: isoform X1
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q78EG7-F1-model_v2 AlphaFold Q78EG7 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696586
Promoter ID:EPDNEW_R7111
Type:initiation region
Name:Ptp4a1_1
Description:protein tyrosine phosphatase type IVA, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0937,231,300 - 37,231,360EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61970 AgrOrtholog
BioCyc Gene G2FUF-27898 BioCyc
Ensembl Genes ENSRNOG00000011771 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000057009 Ensembl
  ENSRNOG00000063494 UniProtKB/TrEMBL
  ENSRNOG00055001636 UniProtKB/Swiss-Prot
  ENSRNOG00060026808 UniProtKB/Swiss-Prot
  ENSRNOG00065010876 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016237 ENTREZGENE
  ENSRNOT00000016237.4 UniProtKB/Swiss-Prot
  ENSRNOT00000103874.1 UniProtKB/TrEMBL
  ENSRNOT00055002621 UniProtKB/Swiss-Prot
  ENSRNOT00060046525 UniProtKB/Swiss-Prot
  ENSRNOT00065017676 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124031 IMAGE-MGC_LOAD
  IMAGE:7446277 IMAGE-MGC_LOAD
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29463 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114303 IMAGE-MGC_LOAD
  MGC:93357 IMAGE-MGC_LOAD
NCBI Gene 29463 ENTREZGENE
PANTHER PROTEIN TYROSINE PHOSPHATASE TYPE IVA 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PhenoGen Ptp4a1 PhenoGen
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011771 RatGTEx
  ENSRNOG00000057009 RatGTEx
  ENSRNOG00000063494 RatGTEx
  ENSRNOG00055001636 RatGTEx
  ENSRNOG00060026808 RatGTEx
  ENSRNOG00065010876 RatGTEx
SMART PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP (Phosphotyrosine protein) phosphatases II UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC229389
UniProt A0A8I5Y1B8 ENTREZGENE, UniProtKB/TrEMBL
  A6IN79 ENTREZGENE, UniProtKB/TrEMBL
  Q4QRA5 ENTREZGENE
  Q78EG7 ENTREZGENE
  Q8VH48 ENTREZGENE
  TP4A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q4QRA5 UniProtKB/Swiss-Prot
  Q8VH48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ptp4a1  protein tyrosine phosphatase 4A1  LOC103693189  protein tyrosine phosphatase type IVA 1  Data merged from RGD:9374124 737654 PROVISIONAL
2019-04-03 Ptp4a1  protein tyrosine phosphatase 4A1  Ptp4a1  protein tyrosine phosphatase type IVA, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693189  protein tyrosine phosphatase type IVA 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-04-12 Ptp4a1  protein tyrosine phosphatase type IVA, member 1  LOC100360241  protein tyrosine phosphatase 4a1-like  Data merged from RGD:2322509 737654 PROVISIONAL
2011-02-22 Ptp4a1  protein tyrosine phosphatase type IVA, member 1  Ptp4a1  protein tyrosine phosphatase 4a1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100360241  protein tyrosine phosphatase 4a1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ptp4a1  protein tyrosine phosphatase 4a1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology similarity to other protein tyrosine phosphatases is limited to the active site consensus sequence 61722
gene_process involved in normal cell growth control and may play a role in cellular tumorigenicity 61722