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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ADAM10 mRNA | CTD | PMID:22808131 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:735848 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of ADAM10 mRNA | CTD | PMID:20829426 | 5-fluorouracil | multiple interactions | ISO | RGD:735847 | 6480464 | TP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAM10 mRNA] | CTD | PMID:15016801 | acrolein | decreases expression | EXP | | 6480464 | Acrolein results in decreased expression of ADAM10 protein | CTD | PMID:23296102 | acrolein | decreases expression | ISO | RGD:735848 | 6480464 | Acrolein results in decreased expression of ADAM10 protein | CTD | PMID:23296102 | all-trans-retinoic acid | affects localization | ISO | RGD:735847 | 6480464 | Tretinoin affects the localization of ADAM10 protein | CTD | PMID:19476501 | all-trans-retinoic acid | increases expression | ISO | RGD:735847 | 6480464 | Tretinoin results in increased expression of ADAM10 mRNA | CTD | PMID:15972296 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:735847 | 6480464 | Tretinoin results in increased expression of ADAM10 mRNA | CTD | PMID:16279945 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:735847 | 6480464 | Tretinoin results in increased expression of ADAM10 protein | CTD | PMID:16279945 PMID:19476501 | all-trans-retinoic acid | increases expression | ISO | RGD:735847 | 6480464 | Tretinoin results in increased expression of ADAM10 mRNA | CTD | PMID:15972296 more ... | all-trans-retinoic acid | increases expression | ISO | RGD:735848 | 6480464 | Tretinoin results in increased expression of ADAM10 mRNA; more ... | CTD | PMID:19476501 | all-trans-retinoic acid | affects localization | ISO | RGD:735848 | 6480464 | Tretinoin affects the localization of ADAM10 protein | CTD | PMID:19476501 | all-trans-retinoic acid | increases expression | ISO | RGD:735847 | 6480464 | Tretinoin results in increased expression of ADAM10 protein | CTD | PMID:19476501 PMID:16279945 | all-trans-retinoic acid | increases expression | ISO | RGD:735847 | 6480464 | Tretinoin results in increased expression of ADAM10 mRNA | CTD | PMID:16279945 more ... | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ADAM10 mRNA | CTD | PMID:16483693 | arsenic atom | decreases expression | ISO | RGD:735848 | 6480464 | Arsenic results in decreased expression of ADAM10 mRNA | CTD | PMID:19654921 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:735848 | 6480464 | Mustard Gas results in increased expression of ADAM10 mRNA | CTD | PMID:15674844 | cadmium dichloride | decreases expression | ISO | RGD:735847 | 6480464 | Cadmium Chloride results in decreased expression of ADAM10 mRNA | CTD | PMID:18560533 | calcium dichloride | increases expression | EXP | | 6480464 | Calcium Chloride results in increased expression of ADAM10 mRNA; more ... | CTD | PMID:20621845 | cisplatin | affects response to substance | ISO | RGD:735847 | 6480464 | ADAM10 protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | cobalt dichloride | decreases expression | ISO | RGD:735847 | 6480464 | cobaltous chloride results in decreased expression of ADAM10 mRNA | CTD | PMID:19376846 PMID:19320972 | cobalt dichloride | decreases expression | ISO | RGD:735847 | 6480464 | cobaltous chloride results in decreased expression of ADAM10 mRNA | CTD | PMID:19320972 PMID:19376846 | dexamethasone | multiple interactions | EXP | | 6480464 | [APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA; more ... | CTD | PMID:22484447 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of ADAM10 mRNA | CTD | PMID:21551480 | fluoxetine | increases expression | EXP | | 6480464 | Fluoxetine results in increased expression of ADAM10 mRNA | CTD | PMID:17033635 | indomethacin | increases expression | EXP | | 6480464 | Indomethacin results in increased expression of ADAM10 mRNA | CTD | PMID:16771604 | methoxychlor | affects expression | ISO | RGD:735848 | 6480464 | Methoxychlor affects the expression of ADAM10 mRNA | CTD | PMID:20829426 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | RGD:735847 | 6480464 | Methylnitronitrosoguanidine results in increased expression of ADAM10 mRNA | CTD | PMID:12634122 | paracetamol | affects expression | ISO | RGD:735848 | 6480464 | Acetaminophen affects the expression of ADAM10 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:735847 | 6480464 | Acetaminophen results in decreased expression of ADAM10 mRNA | CTD | PMID:21420995 | phorbol 12,13-dibutanoate | increases expression | ISO | RGD:735847 | 6480464 | Phorbol 12,13-Dibutyrate results in increased expression of ADAM10 protein | CTD | PMID:19476501 | pirinixic acid | decreases expression | ISO | RGD:735848 | 6480464 | pirinixic acid results in decreased expression of ADAM10 mRNA | CTD | PMID:18445702 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of ADAM10 mRNA | CTD | PMID:12734012 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Pathway Interaction Database | Notch signaling pathway (PID:200015) |
| Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) | |
| Presenilin action in Notch and Wnt signaling (PID:200063) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Alzheimer's disease |
| Pathway Interaction Database | Notch signaling pathway (PID:200015) |
| Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) | |
| Presenilin action in Notch and Wnt signaling (PID:200063) | |
References - curated| 1. |
Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43. |
| 2. |
Chalaris A, etal., Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8. |
| 3. |
Dallas DJ, etal., Bone 1999 Jul;25(1):9-15. |
| 4. |
Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74. |
| 5. |
Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Hartmann D, etal., Hum Mol Genet 2002 Oct 1;11(21):2615-24. |
| 8. |
Howard L, etal., Biochem J 1996 Jul 1;317 ( Pt 1):45-50. |
| 9. |
Lizama C, etal., J Cell Physiol. 2012 Feb;227(2):829-38. doi: 10.1002/jcp.22795. |
| 10. |
MGD data from the GO Consortium |
| 11. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 12. |
Ortiz RM, etal., Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):272-5. Epub 2005 Apr 20. |
| 13. |
Pasternak SH, etal., J Biol Chem 2003 Jul 18;278(29):26687-94. |
| 14. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 15. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 16. |
RGD automated data pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
References - uncurated
RGD Disease Portals| Adam10 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Adam10 (Rattus norvegicus) |
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| ADAM10 (Homo sapiens) |
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| Adam10 (Mus musculus) |
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Position Markers| RH17532 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_019254 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_001054737 | (Get FASTA) | Search GEO for Microarray Profiles | |
| XM_217197 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06055591 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06055592 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055593 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055594 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055595 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055596 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06055597 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055396 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055397 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055398 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055399 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055400 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055401 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055402 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01055403 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474041 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z48444 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001054737 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_001054737 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_217197 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | XP_217197 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_062127 | (Get FASTA) |
| XP_001054737 | (Get FASTA) | |
| XP_217197 | (Get FASTA) | |
| GenBank Protein | CAA88359 | (Get FASTA) |
| EDL84174 | (Get FASTA) | |
| Q10743 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015038 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000021066 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000021066 | UniProtKB/TrEMBL |
| Entrez Gene | 29650 | ENTREZGENE |
| Gene3D-CATH | Blood-coag_inhib_Disintegrin | UniProtKB/Swiss-Prot |
| G3DSA:3.40.390.10 | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000015038 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 865 | ENTREZGENE |
| InterPro | ADAM_10 | UniProtKB/Swiss-Prot |
| Blood-coag_inhib_Disintegrin | UniProtKB/Swiss-Prot | |
| MetalloPept_cat_dom | UniProtKB/Swiss-Prot | |
| Peptidase_M12B | UniProtKB/Swiss-Prot | |
| Peptidase_M12B_N | UniProtKB/TrEMBL | |
| KEGG Report | rno:29650 | ENTREZGENE |
| PANTHER | PTHR11905:SF4 | UniProtKB/Swiss-Prot |
| Pfam | Disintegrin | UniProtKB/Swiss-Prot |
| Pep_M12B_propep | UniProtKB/TrEMBL | |
| PROSITE | ADAM_MEPRO | UniProtKB/Swiss-Prot |
| CYSTEINE_SWITCH; FALSE_NEG | UniProtKB/Swiss-Prot | |
| DISINTEGRIN_1; FALSE_NEG | UniProtKB/Swiss-Prot | |
| DISINTEGRIN_2 | UniProtKB/Swiss-Prot | |
| ZINC_PROTEASE | UniProtKB/Swiss-Prot | |
| SMART | DISIN | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Disintegrin | UniProtKB/Swiss-Prot |
| TIGR | TC231107 | |
| UniGene | Rn.42924 | ENTREZGENE |
| UniProt | ADA10_RAT | UniProtKB/Swiss-Prot |
| F1M8W5_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-18 | Adam10 | ADAM metallopeptidase domain 10 | Adam10 | a disintegrin and metallopeptidase domain 10 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-14 | Adam10 | a disintegrin and metallopeptidase domain 10 | Adam10 | a disintegrin and metalloprotease domain 10 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-14 | Adam10 | a disintegrin and metallopeptidase domain 10 | Adam10 | a disintegrin and metallopeptidase domain 10 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-14 | Adam10 | a disintegrin and metallopeptidase domain 10 | Adam10 | a disintegrin and metallopeptidase domain 10 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Adam10 | a disintegrin and metalloprotease domain 10 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in rat brain | 69738 |
| gene_expression | expressed in neonatal cartilage and bone | 631800 |
| gene_product | member of the reprolysin family | 69738 |
| More on Adam10 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2032 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-06-04 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




