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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1315103 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNA] | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1315103 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNA | CTD | PMID:11007951 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1315103 | 6480464 | decitabine results in increased expression of PIK3CG mRNA | CTD | PMID:17785578 | acetohydrazide | decreases expression | ISO | RGD:1315104 | 6480464 | acetylhydrazine results in decreased expression of PIK3CG mRNA | CTD | PMID:15282401 | afimoxifene | decreases response to substance | ISO | RGD:1315103 | 6480464 | PIK3CG results in decreased susceptibility to 4-hydroxytamoxifen | CTD | PMID:21233418 | all-trans-retinoic acid | increases expression | ISO | RGD:1315103 | 6480464 | Tretinoin results in increased expression of PIK3CG mRNA | CTD | PMID:16054129 | all-trans-retinoic acid | increases expression | ISO | RGD:1315103 | 6480464 | Tretinoin results in increased expression of PIK3CG protein | CTD | PMID:19176369 | all-trans-retinoic acid | increases expression | ISO | RGD:1315103 | 6480464 | Tretinoin results in increased expression of PIK3CG mRNA | CTD | PMID:15498508 PMID:16054129 | all-trans-retinoic acid | increases expression | ISO | RGD:1315103 | 6480464 | Tretinoin results in increased expression of PIK3CG mRNA | CTD | PMID:16054129 PMID:15498508 | arsenite(3-) | decreases expression | ISO | RGD:1315104 | 6480464 | arsenite results in decreased expression of PIK3CG mRNA | CTD | PMID:18191166 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:1315104 | 6480464 | Mustard Gas results in increased expression of PIK3CG mRNA | CTD | PMID:18955075 | cisplatin | decreases response to substance | ISO | RGD:1315103 | 6480464 | PIK3CG results in decreased susceptibility to Cisplatin | CTD | PMID:21652733 | cycloheximide | multiple interactions | ISO | RGD:1315103 | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3CG mRNA] | CTD | PMID:11007951 | diazoxide | multiple interactions | ISO | RGD:1315104 | 6480464 | wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]; more ... | CTD | PMID:15178407 | diazoxide | increases activity | ISO | RGD:1315104 | 6480464 | Isoproterenol results in increased activity of PIK3CG protein | CTD | PMID:15178407 | glycyrrhetinate | decreases activity | ISO | RGD:1315104 | 6480464 | 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CG protein | CTD | PMID:21644799 | glycyrrhetinic acid | decreases activity | ISO | RGD:1315104 | 6480464 | 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CG protein | CTD | PMID:21644799 | glycyrrhizinic acid | decreases activity | ISO | RGD:1315104 | 6480464 | Glycyrrhizic Acid results in decreased activity of PIK3CG protein | CTD | PMID:21644799 | hydrazine | decreases expression | ISO | RGD:1315104 | 6480464 | hydrazine results in decreased expression of PIK3CG mRNA | CTD | PMID:15282401 | isoprenaline | multiple interactions | ISO | RGD:1315104 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]; more ... | CTD | PMID:15178407 | isoprenaline | increases activity | ISO | RGD:1315104 | 6480464 | Isoproterenol results in increased activity of PIK3CG protein | CTD | PMID:15178407 | LY294002 | multiple interactions | ISO | RGD:1315103 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Am 80 results in increased expression of and results in increased activity of PIK3CG protein]; more ... | CTD | PMID:15020266 | LY294002 | decreases activity | ISO | RGD:1315103 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CG protein | CTD | PMID:16794257 | LY294002 | multiple interactions | ISO | RGD:1315104 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein] | CTD | PMID:15178407 | LY294002 | decreases activity | ISO | RGD:1315104 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CG protein | CTD | PMID:16179367 | quercetin | decreases activity | ISO | RGD:1315103 | 6480464 | Quercetin results in decreased activity of PIK3CG protein | CTD | PMID:16794257 | resveratrol | decreases activity | ISO | RGD:1315103 | 6480464 | resveratrol results in decreased activity of PIK3CG protein | CTD | PMID:17550345 | silicon dioxide | decreases expression | ISO | RGD:1315104 | 6480464 | Silicon Dioxide results in decreased expression of PIK3CG mRNA | CTD | PMID:19073995 | tamibarotene | increases expression | ISO | RGD:1315103 | 6480464 | Am 80 results in increased expression of PIK3CG mRNA; more ... | CTD | PMID:15020266 PMID:15498508 | tamibarotene | multiple interactions | ISO | RGD:1315103 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Am 80 results in increased expression of and results in increased activity of PIK3CG protein]; more ... | CTD | PMID:15020266 | tamibarotene | increases expression | ISO | RGD:1315103 | 6480464 | Am 80 results in increased expression of PIK3CG mRNA | CTD | PMID:15498508 PMID:15020266 | trans-resveratrol | decreases activity | ISO | RGD:1315103 | 6480464 | resveratrol results in decreased activity of PIK3CG protein | CTD | PMID:17550345 | wortmannin | multiple interactions | ISO | RGD:1315104 | 6480464 | wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein] | CTD | PMID:15178407 | wortmannin | decreases activity | ISO | RGD:1315104 | 6480464 | wortmannin results in decreased activity of PIK3CG protein | CTD | PMID:21644799 | zinc dichloride | multiple interactions | ISO | RGD:1315104 | 6480464 | PIK3CG protein affects the reaction [zinc chloride results in increased activity of MAP3K1 protein]; more ... | CTD | PMID:11306679 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Aldosterone-regulated sodium reabsorption | |
| Amoebiasis | |
| Apoptosis | |
| B cell receptor signaling pathway | |
| Bacterial invasion of epithelial cells | |
| Carbohydrate digestion and absorption | |
| Chagas disease (American trypanosomiasis) | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Endometrial cancer | |
| Epstein-Barr virus infection | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Fc gamma R-mediated phagocytosis | |
| Focal adhesion | |
| Glioma | |
| Hepatitis B | |
| Hepatitis C | |
| HIF-1 signaling pathway | |
| HTLV-I infection | |
| Influenza A | |
| Inositol phosphate metabolism | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| Leukocyte transendothelial migration | |
| Measles | |
| Melanoma | |
| mTOR signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Neurotrophin signaling pathway | |
| Non-small cell lung cancer | |
| Osteoclast differentiation | |
| Pancreatic cancer | |
| Pathways in cancer | |
| Phosphatidylinositol signaling system | |
| PI3K-Akt signaling pathway | |
| Progesterone-mediated oocyte maturation | |
| Prostate cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| Small cell lung cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Toxoplasmosis | |
| Type II diabetes mellitus | |
| VEGF signaling pathway | |
| Viral carcinogenesis | |
| Pathway Interaction Database | Class I PI3K signaling events (PID:200116) |
| Class IB PI3K non-lipid kinase events (PID:200097) | |
| CXCR4-mediated signaling events (PID:200099) | |
| EPHA forward signaling (PID:200142) | |
| IL8- and CXCR1-mediated signaling events (PID:200199) | |
| IL8- and CXCR2-mediated signaling events (PID:200167) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Thromboxane A2 receptor signaling (PID:200082) | |
References - curated| 1. |
Baragli A, etal., Biochim Biophys Acta. 2011 Jun;1811(6):386-96. Epub 2011 Mar 22. |
| 2. |
Barber DF, etal., J Immunol. 2006 Jan 1;176(1):589-93. |
| 3. |
Becattini B, etal., Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. Epub 2011 Sep 26. |
| 4. |
Bony C, etal., J Cell Biol. 2001 Feb 19;152(4):717-28. |
| 5. |
Castor MG, etal., J Leukoc Biol. 2011 Jun;89(6):955-64. Epub 2011 Mar 14. |
| 6. |
Chang JD, etal., Proc Natl Acad Sci U S A. 2007 May 8;104(19):8077-82. Epub 2007 May 2. |
| 7. |
Druse MJ, etal., Brain Res. 2007 May 30;1150:46-54. Epub 2007 Mar 13. |
| 8. |
Dutra RC, etal., Br J Pharmacol. 2011 May;163(2):358-74. doi: 10.1111/j.1476-5381.2011.01226.x. |
| 9. |
Ferrandi C, etal., J Pharmacol Exp Ther. 2007 Sep;322(3):923-30. Epub 2007 May 25. |
| 10. |
GOA data from the GO Consortium |
| 11. |
Gonzalez-Garcia A, etal., Gastroenterology. 2010 Apr;138(4):1374-83. Epub 2009 Dec 11. |
| 12. |
Gruen M, etal., BMC Musculoskelet Disord. 2010 Apr 7;11:63. |
| 13. |
Haubner BJ, etal., PLoS One. 2010 Feb 22;5(2):e9350. |
| 14. |
Hohenester S, etal., J Hepatol. 2010 Nov;53(5):918-26. Epub 2010 Jul 17. |
| 15. |
Jantarajit W, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E372-84. Epub 2007 May 8. |
| 16. |
Jin R, etal., Stroke. 2011 Jul;42(7):2033-44. Epub 2011 May 5. |
| 17. |
Kaplan-Albuquerque N, etal., J Biol Chem. 2003 Oct 10;278(41):39830-8. Epub 2003 Jul 25. |
| 18. |
Kim DI, etal., J Clin Immunol. 2012 Apr;32(2):340-51. Epub 2011 Dec 24. |
| 19. |
Kobayashi T and Puro DG, Invest Ophthalmol Vis Sci. 2007 May;48(5):2350-5. |
| 20. |
Lionetti V, etal., Crit Care Med. 2006 Jan;34(1):134-41. |
| 21. |
Martin EL, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):762-73. Epub 2010 May 27. |
| 22. |
MGD data from the GO Consortium |
| 23. |
Nguyen T, etal., Am J Pathol. 2007 Apr;170(4):1219-28. |
| 24. |
Passos GF, etal., Brain Behav Immun. 2010 Mar;24(3):493-501. Epub 2009 Dec 16. |
| 25. |
Perrino C, etal., J Am Coll Cardiol. 2005 Jun 7;45(11):1862-70. |
| 26. |
Pigeau GM, etal., Diabetes. 2009 Sep;58(9):2084-92. Epub 2009 Jun 23. |
| 27. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 28. |
Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24. |
| 29. |
RGD automated data pipeline |
| 30. |
RGD automated import pipeline for gene-chemical interactions |
| 31. |
RGD comprehensive gene curation |
| 32. |
Rodrigues DH, etal., J Neuroimmunol. 2010 May;222(1-2):90-4. Epub 2010 Mar 19. |
| 33. |
Serajee FJ, etal., J Med Genet. 2003 Nov;40(11):e119. |
| 34. |
Siragusa M, etal., Circ Res. 2010 Mar 5;106(4):757-68. Epub 2010 Jan 7. |
| 35. |
Song LF, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):471-4. |
| 36. |
Thomas M, etal., Immunology. 2009 Mar;126(3):413-22. Epub 2008 Aug 27. |
| 37. |
Tosaka S, etal., J Anesth. 2007;21(2):176-80. Epub 2007 May 30. |
| 38. |
Wierod L, etal., Cell Prolif. 2007 Aug;40(4):475-87. |
| 39. |
Yu HP, etal., Ann Surg. 2007 Jun;245(6):971-7. |
| 40. |
Yuan G, etal., Endocrinology. 2007 May;148(5):2016-26. Epub 2007 Feb 1. |
| 41. |
Zhang Y, etal., Planta Med. 2007 Apr;73(4):341-7. Epub 2007 Apr 18. |
References - uncurated| PubMed | 12538627 |
| 14762792 | |
| 15385964 | |
| 16130182 | |
| 16343426 | |
| 16414349 | |
| 16762504 | |
| 16989733 | |
| 17016676 | |
| 17555093 | |
| 17630321 | |
| 17885802 | |
| 17893321 | |
| 17942284 | |
| 18071753 | |
| 18163378 | |
| 18163380 | |
| 18269915 | |
| 18299886 | |
| 18410228 | |
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| 18616564 | |
| 18635661 | |
| 18663086 | |
| 18785877 | |
| 18791856 | |
| 19015400 | |
| 19060913 | |
| 19255141 | |
| 19279233 | |
| 19381068 | |
| 19531027 | |
| 19698760 | |
| 19709371 | |
| 19804812 | |
| 19896516 | |
| 19997978 | |
| 20093365 | |
| 20333648 | |
| 20371878 | |
| 20383584 | |
| 20404059 | |
| 20665543 | |
| 20821260 | |
| 20870746 | |
| 20953735 | |
| 20967511 | |
| 21042752 | |
| 21182226 | |
| 21219473 | |
| 21498085 | |
| 21683721 | |
| 21822733 | |
| 21984198 | |
| 22166507 | |
| 22316281 | |
| 22447946 | |
| 22490886 | |
| 22553040 | |
| 22702339 |
RGD Disease Portals| Pik3cg has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pik3cg (Rattus norvegicus) |
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| PIK3CG (Homo sapiens) |
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| Pik3cg (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | XM_003750140 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_003754199 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06043313 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01043257 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01043258 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473947 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001106723 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003750140 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_003750188 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003754199 |
| RefSeq Status: | |
| Type: | CODING |
| Protein Acc Id: | XP_003754247 |
| Position: | No map positions available. |
Protein Sequences| Protein RefSeqs | XP_003750188 | (Get FASTA) |
| XP_003754247 | (Get FASTA) | |
| GenBank Protein | EDM03267 | (Get FASTA) |
| EDM03268 | (Get FASTA) | |
| EDM03269 | (Get FASTA) | |
| EDM03270 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009385 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000012487 | UniProtKB/TrEMBL |
| ENSRNOP00000047877 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000012487 | UniProtKB/TrEMBL |
| ENSRNOT00000045589 | UniProtKB/TrEMBL | |
| Entrez Gene | 298947 | ENTREZGENE |
| Gene3D-CATH | 070.11 | UniProtKB/TrEMBL |
| PI3Ka | UniProtKB/TrEMBL | |
| HomoloGene Group ID | 68269 | ENTREZGENE |
| InterPro | ARM-type_fold | UniProtKB/TrEMBL |
| C2_Ca/lipid-bd_dom_CaLB | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| PI3/4_kinase_cat_dom | UniProtKB/TrEMBL | |
| PI3/4_kinase_CS | UniProtKB/TrEMBL | |
| PI3K_adapt-bd_dom | UniProtKB/TrEMBL | |
| PI3K_C2 | UniProtKB/TrEMBL | |
| PI3K_ras-bd | UniProtKB/TrEMBL | |
| PI_Kinase | UniProtKB/TrEMBL | |
| PInositide-3_kin_accessory_dom | UniProtKB/TrEMBL | |
| IPI | IPI00366901 | UniProtKB/TrEMBL |
| IPI00561856 | UniProtKB/TrEMBL | |
| KEGG Report | rno:298947 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | PI_Kinase | UniProtKB/TrEMBL |
| Pfam | PI3_PI4_kinase | UniProtKB/TrEMBL |
| PI3K_C2 | UniProtKB/TrEMBL | |
| PI3K_rbd | UniProtKB/TrEMBL | |
| PI3Ka | UniProtKB/TrEMBL | |
| PROSITE | PI3_4_KINASE_1 | UniProtKB/TrEMBL |
| PI3_4_KINASE_2 | UniProtKB/TrEMBL | |
| PI3_4_KINASE_3 | UniProtKB/TrEMBL | |
| PI3K_ABD | UniProtKB/TrEMBL | |
| PI3K_C2 | UniProtKB/TrEMBL | |
| PI3K_RBD | UniProtKB/TrEMBL | |
| PIK_HELICAL | UniProtKB/TrEMBL | |
| SMART | PI3K_C2 | UniProtKB/TrEMBL |
| PI3K_rbd | UniProtKB/TrEMBL | |
| PI3Ka | UniProtKB/TrEMBL | |
| PI3Kc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | ARM-type_fold | UniProtKB/TrEMBL |
| C2_CaLB | UniProtKB/TrEMBL | |
| Kinase_like | UniProtKB/TrEMBL | |
| UniProt | D3ZFJ0_RAT | UniProtKB/TrEMBL |
| D3ZRN0_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-10 | Pik3cg | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | Pik3cg_predicted | phosphoinositide-3-kinase, catalytic, gamma polypeptide (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Pik3cg_predicted | phosphoinositide-3-kinase, catalytic, gamma polypeptide (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Pik3cg | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1306468 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




