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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,3-dinitrobenzene | increases expression | EXP | | 6480464 | 3-dinitrobenzene results in increased expression of WNT2 mRNA | CTD | PMID:21983209 | 17beta-estradiol | increases expression | ISO | RGD:736431 | 6480464 | Estradiol results in increased expression of WNT2 mRNA | CTD | PMID:15072547 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:736432 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of WNT2 mRNA | CTD | PMID:18172886 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of WNT2 mRNA | CTD | PMID:23238561 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:736432 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of WNT2 mRNA | CTD | PMID:23238561 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736432 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to WNT2 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:736432 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of WNT2 mRNA | CTD | PMID:16214954 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:736432 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of WNT2 mRNA | CTD | PMID:18648102 | all-trans-retinoic acid | decreases expression | ISO | RGD:736431 | 6480464 | Tretinoin results in decreased expression of WNT2 mRNA | CTD | PMID:17045167 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of WNT2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:736432 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to WNT2 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases expression | ISO | RGD:736432 | 6480464 | Benzo(a)pyrene results in increased expression of WNT2 mRNA | CTD | PMID:22228805 | cadmium dichloride | multiple interactions | ISO | RGD:736431 | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNA | CTD | PMID:12634122 | chloroprene | decreases expression | ISO | RGD:736432 | 6480464 | Chloroprene results in decreased expression of WNT2 mRNA | CTD | PMID:23125180 | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of WNT2 mRNA | CTD | PMID:23125180 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of WNT2 mRNA | CTD | PMID:18502319 | diazinon | decreases expression | EXP | | 6480464 | Diazinon results in decreased expression of WNT2 mRNA | CTD | PMID:18502319 | dichromium trioxide | multiple interactions | ISO | RGD:736431 | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNA | CTD | PMID:12634122 | dieldrin | decreases expression | EXP | | 6480464 | Dieldrin results in decreased expression of WNT2 mRNA | CTD | PMID:19130878 | fulvestrant | decreases expression | ISO | RGD:736431 | 6480464 | fulvestrant results in decreased expression of WNT2 mRNA | CTD | PMID:15072547 | lead diacetate | multiple interactions | ISO | RGD:736431 | 6480464 | [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of WNT2 mRNA | CTD | PMID:12634122 | N-methyl-N'-nitro-N-nitrosoguanidine | increases expression | ISO | RGD:736431 | 6480464 | Methylnitronitrosoguanidine results in increased expression of WNT2 mRNA | CTD | PMID:12634122 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of WNT2 mRNA | CTD | PMID:19130878 | paracetamol | affects expression | ISO | RGD:736432 | 6480464 | Acetaminophen affects the expression of WNT2 mRNA | CTD | PMID:17562736 | phenobarbital | affects expression | ISO | RGD:736432 | 6480464 | Phenobarbital affects the expression of WNT2 mRNA | CTD | PMID:23091169 | silicon dioxide | increases expression | ISO | RGD:736431 | 6480464 | Silicon Dioxide results in increased expression of WNT2 mRNA | CTD | PMID:21540303 | valproic acid | decreases methylation | EXP | | 6480464 | Valproic Acid results in decreased methylation of WNT2 promoter | CTD | PMID:20734317 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of WNT2 mRNA; more ... | CTD | PMID:20734317 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Basal cell carcinoma |
| Hedgehog signaling pathway | |
| Hippo signaling pathway | |
| HTLV-I infection | |
| Melanogenesis | |
| Pathways in cancer | |
| Wnt signaling pathway | |
| Pathway Interaction Database | Wnt signaling network (PID:200067) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Basal cell carcinoma |
| Hedgehog signaling pathway | |
| Hippo signaling pathway | |
| HTLV-I infection | |
| Melanogenesis | |
| Pathways in cancer | |
| Wnt signaling pathway | |
| Pathway Interaction Database | Wnt signaling network (PID:200067) |
References - curated| 1. |
Bui TD, etal., Br J Cancer. 1997;75(8):1131-6. |
| 2. |
Erdreich-Epstein A and Shackleford GM, Growth Factors 1998;15(2):149-58. |
| 3. |
Fujise T, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1150-6. Epub 2006 Dec 28. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Habuchi T, etal., J Natl Cancer Inst. 1994 Sep 7;86(17):1331-5. |
| 6. |
Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21. |
| 7. |
Karasawa T, etal., J Biol Chem 2002 Oct 4;277(40):37479-86. |
| 8. |
Klein D, etal., Hepatology. 2008 Mar;47(3):1018-31. |
| 9. |
Levay-Young BK and Navre M, Am J Physiol. 1992 Jun;262(6 Pt 1):L672-83. |
| 10. |
Madsen TM, etal., Biol Psychiatry. 2003 Nov 15;54(10):1006-14. |
| 11. |
MGD data from the GO Consortium |
| 12. |
Nagayama K and Watatani M, Jpn J Cancer Res. 1993 Nov;84(11):1159-64. |
| 13. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 14. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 15. |
RGD automated data pipeline |
| 16. |
RGD automated import pipeline for gene-chemical interactions |
| 17. |
RGD comprehensive gene curation |
| 18. |
Ricken A, etal., Endocrinology 2002 Jul;143(7):2741-9. |
| 19. |
Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA |
| 20. |
Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58. |
| 21. |
van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9. |
| 22. |
Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73. |
| 23. |
Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8. |
| 24. |
Watanabe O, etal., Anticancer Res. 2004 Nov-Dec;24(6):3851-6. |
| 25. |
Wissmann C, etal., J Pathol 2003 Oct;201(2):204-12. |
| 26. |
Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86. |
References - uncuratedRGD Disease Portals| Wnt2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Wnt2 (Rattus norvegicus) |
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| WNT2 (Homo sapiens) |
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| Wnt2 (Mus musculus) |
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Position Markers| RH141342 |
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| RH130031 |
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| REN63976 |
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| Wnt2 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | XM_001059030 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_575397 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06029880 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01028821 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC095247 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF352176 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF352177 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF352178 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473959 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DP000027 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001059030 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_001059030 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_575397 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | XP_575397 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | XP_001059030 | (Get FASTA) |
| XP_575397 | (Get FASTA) | |
| GenBank Protein | AAK32712 | (Get FASTA) |
| AAK32713 | (Get FASTA) | |
| AAR16313 | (Get FASTA) | |
| EDM15125 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000007843 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000010427 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000010427 | UniProtKB/TrEMBL |
| Entrez Gene | 114487 | ENTREZGENE |
| HomoloGene Group ID | 20719 | ENTREZGENE |
| InterPro | Wnt2 | UniProtKB/TrEMBL |
| Wnt_CS | UniProtKB/TrEMBL | |
| Wnt_SF | UniProtKB/TrEMBL | |
| IPI | IPI00325021 | UniProtKB/TrEMBL |
| KEGG Report | rno:114487 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | PTHR12027:SF21 | UniProtKB/TrEMBL |
| Wnt | UniProtKB/TrEMBL | |
| Pfam | wnt | UniProtKB/TrEMBL |
| PRINTS | WNT2PROTEIN | UniProtKB/TrEMBL |
| WNTPROTEIN | UniProtKB/TrEMBL | |
| PROSITE | WNT1 | UniProtKB/TrEMBL |
| SMART | WNT1 | UniProtKB/TrEMBL |
| UniGene | Rn.223092 | ENTREZGENE |
| UniProt | Q2IBD1_RAT | UniProtKB/TrEMBL |
| Q99MC2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-11-14 | Wnt2 | wingless-type MMTV integration site family member 2 | Wnt2 | wingless-related MMTV integration site 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2003-04-09 | Wnt2 | wingless-related MMTV integration site 2 | Symbol and Name updated | 2574 | APPROVED | ||
| 2003-03-12 | Wnt2 | wingless-related MMTV integration site 2 | Wnt | Data Merged | 2447 | PROVISIONAL | |
| 2002-08-07 | Wnt2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL | |||
| 2002-08-07 | Wnt | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in uterus | 70557 |
| gene_process | upregulated in uterine tumors | 70557 |
| More on Wnt2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621346 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.