RGD Reference Report - Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis. - Rat Genome Database

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Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis.

Authors: Madsen, TM  Newton, SS  Eaton, ME  Russell, DS  Duman, RS 
Citation: Madsen TM, etal., Biol Psychiatry. 2003 Nov 15;54(10):1006-14.
RGD ID: 2326231
Pubmed: PMID:14625142   (View Abstract at PubMed)

BACKGROUND: Beta-catenin was discovered as a cytoskeletal protein, constituting a link between the cadherins to the actin cytoskeleton. Aside from this function, beta-catenin is a key effector molecule in the Wnt signaling pathway, serving as a downstream transcription factor. METHODS: In this study, we examined the influence of electroconvulsive seizures (ECS) on the expression of beta-catenin, as well as expression of Wnt-2, in rat hippocampus. Repeated administration of generalized seizures increased levels of beta-catenin immunoreactivity in the subgranular zone of the hippocampus. To assess the relationship of beta-catenin to cell division in the dentate gyrus of the adult rat hippocampus, colocalization of beta-catenin with a marker of cell division was examined. RESULTS: Beta-catenin immunoreactivity was consistently localized in newborn cells in this region, indicating a possible role in cell division and differentiation in adult hippocampus. We also found that ECS treatment significantly increased levels of Wnt-2, one of the ligands that activates beta-catenin signaling. CONCLUSIONS: These results demonstrate that ECS increases Wnt-beta-catenin signaling and suggest that this pathway could mediate in part the neuronal adaptations underlying the therapeutic action of this treatment paradigm.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WNT2Humanvisual epilepsy  ISOWnt2 (Rattus norvegicus)mRNA:increased expression:hippocampusRGD 
Wnt2Ratvisual epilepsy  IEP mRNA:increased expression:hippocampusRGD 
Wnt2Mousevisual epilepsy  ISOWnt2 (Rattus norvegicus)mRNA:increased expression:hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Wnt2  (Wnt family member 2)

Genes (Mus musculus)
Wnt2  (wingless-type MMTV integration site family, member 2)

Genes (Homo sapiens)
WNT2  (Wnt family member 2)


Additional Information