RGD Reference Report - Analysis of genetic alterations related to the development and progression of breast carcinoma. - Rat Genome Database

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Analysis of genetic alterations related to the development and progression of breast carcinoma.

Authors: Nagayama, K  Watatani, M 
Citation: Nagayama K and Watatani M, Jpn J Cancer Res. 1993 Nov;84(11):1159-64.
RGD ID: 2291879
Pubmed: PMID:7903963   (View Abstract at PubMed)
PMCID: PMC5919097   (View Article at PubMed Central)

To study genetic alterations related to the development and/or progression of breast carcinoma, we examined amplification of the ERBB2, INT2, and MYC genes, as well as loss of heterozygosity (LOH) at loci on 11p, 16q, 17p (D17S5 and TP53), 17q (D17S74 and NME1), and 18q by restriction fragment length polymorphism analysis. The subjects were 26 patients with small breast carcinomas (< or = 2 cm) and 88 patients with larger breast carcinomas (2 to < 5 cm). All patients were free of distant metastasis. As tumor diameter increased, the frequency of oncogene amplification and LOH at all loci except D17S5 increased. However, there was no relationship between tumor diameter and amplification of specific oncogenes or allelic loss at specific loci. LOH at D17S5 was detected in 40% of small breast carcinomas (< or = 2 cm) and 43% of larger breast carcinomas (2 to < 5 cm). There was a significant correlation of LOH at D17S5 with INT2 amplification or with LOH on 11p, 16q, and 18q. These findings suggest that LOH at D17S5 may be involved in the early stage of breast carcinoma development, while INT2 amplification and LOH at 11p, 16q, and 18q appear to be genetic alterations that occur with tumor progression. In addition, as lymph node metastases were significantly related to amplification of the ERBB2 and MYC genes, and LOH of the NME1 gene, these genetic alterations may play a role in the mechanism of lymph node metastases.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WNT2Humanbreast carcinoma disease_progressionIAGP DNA:amplification:breastRGD 
Wnt2Ratbreast carcinoma disease_progressionISOWNT2 (Homo sapiens)DNA:amplification:breastRGD 
Wnt2Mousebreast carcinoma disease_progressionISOWNT2 (Homo sapiens)DNA:amplification:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Wnt2  (Wnt family member 2)

Genes (Mus musculus)
Wnt2  (wingless-type MMTV integration site family, member 2)

Genes (Homo sapiens)
WNT2  (Wnt family member 2)


Additional Information