HEDGEHOG SIGNALING PATHWAY (PW:0000122)

View Ontology Report

Description

First discovered in Drosophila, the Hedgehog (Hh) signaling pathway is now regarded as a key regulator of mammalian embryogenesis important for processes such as cell proliferation and differentiation while in the adult it is involved in tissue repair and regeneration and the maintenance of stem cells. The three mammalian Hh genes - Dhh, Ihh and Shh, have distinct patterns of expression; only Shh is broadly expressed in many tissues. In the producing/sending cells, self-cleavage of Hh yields th

Pathway Diagram:

Ariadne Genomics Inc. Gli targets translocated Gli Gli proteins Gli modfiying kinases Ptch1 Lrp2 heparan sulfate proteoglycans secreted Hh Hh ligands palmitate GAS1 PTCH2 HHAT Btrc Gli modfiying kinases ---| Gli proteins Sufu ---| Gli proteins Smo_translocated ---| Sufu Sufu Hh ligands ---> secreted Hh Smo_translocated Smo Hh ligands ---- Lrp2 Lrp2 ---- secreted Hh Disp1 HHAT ---> Hh ligands Disp1 ---- Hh ligands secreted Hh ---| Ptch1 Gli proteins ---> translocated Gli translocated Gli ---> Gli targets Smo ---> Smo_translocated Cdon Boc PTCH2 ---| Smo Cdon --+> secreted Hh Boc ---- secreted Hh GAS1 ---- secreted Hh Btrc ---| Gli proteins secreted Hh ---| PTCH2 PTCH2 ---- secreted Hh Ptch1 ---- secreted Hh Hhip ---- secreted Hh Boc --+> secreted Hh GAS1 --+> secreted Hh Hhip ---| secreted Hh Cdon ---- secreted Hh Ptch1 ---| Smo Hhip
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Genes in Pathway:

show annotations for term's descendants       view all columns
Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6484113
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:6484113
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:6907045
G Bmp4 bone morphogenetic protein 4 JBrowse link 15 20,776,060 20,791,013 RGD:6907045
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:6907045
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:6907045
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:6907045
G Bmp8a bone morphogenetic protein 8a JBrowse link 5 141,007,462 141,033,511 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5510025
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:5510026
RGD:6907045
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:5510025
RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6484113
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6484113
RGD:6907045
G Csnk1d casein kinase 1, delta JBrowse link 10 110,147,786 110,182,413 RGD:6484113
RGD:6907045
G Csnk1e casein kinase 1, epsilon JBrowse link 7 120,651,976 120,675,559 RGD:6484113
RGD:6907045
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:6484113
RGD:6907045
G Csnk1g2 casein kinase 1, gamma 2 JBrowse link 7 11,944,957 11,963,268 RGD:6484113
RGD:6907045
G Csnk1g3 casein kinase 1, gamma 3 JBrowse link 18 48,831,209 48,913,341 RGD:6484113
RGD:6907045
G Dhh desert hedgehog JBrowse link 7 140,575,288 140,580,783 RGD:634737
RGD:5510013
RGD:5510025
RGD:6484113
RGD:6907045
G Disp1 dispatched RND transporter family member 1 JBrowse link 13 101,451,932 101,597,570 RGD:5510026
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:6484113
RGD:6907045
G Foxa2 forkhead box A2 JBrowse link 3 142,383,084 142,387,493 RGD:6484113
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5510013
RGD:5510026
RGD:6484113
RGD:6907045
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:5510013
RGD:5510026
RGD:6484113
RGD:6907045
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:5510013
RGD:5510026
RGD:6484113
RGD:6907045
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6484113
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6484113
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6484113
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:6484113
G Gnaz G protein subunit alpha z JBrowse link 20 14,593,072 14,644,020 RGD:6484113
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:6484113
G Gng2 G protein subunit gamma 2 JBrowse link 15 4,748,242 4,853,555 RGD:6484113
G Gpc1 glypican 1 JBrowse link 9 99,998,275 100,026,818 RGD:5510027
G Gpc2 glypican 2 JBrowse link 12 19,593,041 19,599,374 RGD:5510027
G Gpc3 glypican 3 JBrowse link X 139,579,268 139,947,093 RGD:5510027
G Gpc4 glypican 4 JBrowse link X 139,354,325 139,464,876 RGD:5510027
G Gpc5 glypican 5 JBrowse link 15 100,283,131 101,776,838 RGD:5510027
G Grk2 G protein-coupled receptor kinase 2 JBrowse link 1 219,536,220 219,544,329 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:5510026
RGD:6484113
RGD:6907045
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6484113
G Hdac2 histone deacetylase 2 JBrowse link 20 43,084,870 43,108,198 RGD:6484113
G Hhat hedgehog acyltransferase JBrowse link 13 111,235,325 111,489,075 RGD:6484113
G Hhip Hedgehog-interacting protein JBrowse link 19 31,525,134 31,614,487 RGD:5510025
RGD:6484113
RGD:6907045
G Hspg2 heparan sulfate proteoglycan 2 JBrowse link 5 155,812,096 155,913,751 RGD:5510033
G Ift172 intraflagellar transport 172 JBrowse link 6 26,390,686 26,485,459 RGD:6484113
G Ift88 intraflagellar transport 88 JBrowse link 15 37,690,417 37,786,855 RGD:6484113
G Ihh Indian hedgehog JBrowse link 9 82,208,223 82,214,440 RGD:1299259
RGD:5510013
RGD:5510025
RGD:6484113
RGD:6907045
G Kif3a kinesin family member 3a JBrowse link 10 38,918,705 38,953,958 RGD:6484113
G Lgals3 galectin 3 JBrowse link 15 24,153,602 24,165,537 RGD:6484113
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5510026
RGD:6484113
RGD:6907045
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:6484113
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6484113
G Mtss1 MTSS1, I-BAR domain containing JBrowse link 7 98,820,799 98,960,878 RGD:6484113
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:6484113
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6484113
RGD:6907045
G Prkacb protein kinase cAMP-activated catalytic subunit beta JBrowse link 2 252,602,197 252,691,886 RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:6484113
G Prkx protein kinase, X-linked JBrowse link X 45,080,963 45,125,095 RGD:6907045
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
RGD:5510013
RGD:5510026
RGD:6484113
RGD:6907045
G Pthlh parathyroid hormone-like hormone JBrowse link 4 181,663,425 181,674,181 RGD:6484113
G Rab23 RAB23, member RAS oncogene family JBrowse link 9 38,469,784 38,496,185 RGD:6484113
RGD:6907045
G Rbbp4 RB binding protein 4, chromatin remodeling factor JBrowse link 5 147,499,880 147,535,240 RGD:6484113
G Rbbp7 RB binding protein 7, chromatin remodeling factor JBrowse link X 33,648,682 33,665,821 RGD:6484113
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:628387
RGD:5510013
RGD:5510025
RGD:6484113
RGD:6907045
G Sin3a SIN3 transcription regulator family member A JBrowse link 8 61,748,590 61,803,314 RGD:6484113
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355
RGD:5510013
RGD:5510026
RGD:6484113
RGD:6907045
G Spop speckle type BTB/POZ protein JBrowse link 10 83,231,187 83,311,987 RGD:6484113
G Sspo SCO-spondin JBrowse link 4 78,076,695 78,133,676 RGD:6484113
G Stil STIL, centriolar assembly protein JBrowse link 5 133,819,302 133,851,362 RGD:6484113
G Stk36 serine/threonine kinase 36 JBrowse link 9 81,880,175 81,908,014 RGD:6484113
RGD:6907045
G Sufu SUFU negative regulator of hedgehog signaling JBrowse link 1 266,143,766 266,241,742 RGD:5510013
RGD:6484113
RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6484113
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:6907045
G Wnt10a Wnt family member 10A JBrowse link 9 82,053,581 82,066,047 RGD:6907045
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:6907045
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:6907045
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:6907045
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:6907045
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:6907045
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:6907045
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6907045
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:6907045
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:6907045
G Wnt5b Wnt family member 5B JBrowse link 4 151,500,962 151,516,894 RGD:6907045
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:6907045
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:6907045
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:6907045
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:6907045
G Wnt8b Wnt family member 8B JBrowse link 1 264,244,150 264,266,136 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:6907045
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:6907045
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:6484113
G Zic2 Zic family member 2 JBrowse link 15 108,908,366 108,913,812 RGD:6907045
altered Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Dhh desert hedgehog JBrowse link 7 140,575,288 140,580,783 RGD:634737
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5490966
RGD:5491005
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:5490966
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:628387
RGD:5490965
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional Classsecreted HhHh ligands, processed and secreted
Functional ClassGli modifying kinaseskinases, families and pathways that modify Gli
Functional Classheparan sulfate proteoglycansproteoglycans involved in in logn distance transport and regulation of Hh signaling
Gene GroupGli targetstarget genes of Gli
Functional ClassGli membersthe members of Gli family of transcription factors
Functional ClassHh ligandsthe three Hedgehog ligands

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Hedgehog signaling pathway
Disease TermsGene Symbols
15q24 MicrodeletionSin3a
46,XX Sex Reversal with Dysgenesis of Kidneys, Adrenals, and LungsWnt4
46,XY Gonadal Dysgenesis, Complete or Partial, DHH-RelatedDhh
46,Xy Gonadal Dysgenesis, Partial, with Minifascicular NeuropathyDhh
Aberrant Crypt FociGsk3b
Abnormalities, Drug-InducedWnt11
Abnormalities, MultipleCrebbp , Gnao1 , Gsk3b , Hdac1
Abortion, SpontaneousLgals3 , Pthlh
Absence of Tibia with PolydactylyShh
Acrocapitofemoral DysplasiaIhh
ACTH-Secreting Pituitary AdenomaBmp4 , Gnai2
Acute Kidney InjuryGsk3b , Hdac2 , Lgals3 , Wnt4
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaPik3ca
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungAkt1 , Crebbp , Map2k1 , Pik3ca
ADENOCARCINOMA OF STOMACHAkt1 , Crebbp , Map2k1 , Pik3ca
Adenocarcinoma, ColorectalGsk3b
Adenocarcinoma, ProstaticAkt1 , Map2k1 , Pik3ca , Spop , Xpo1
Adenomatous Polyposis ColiAkt1 , Hdac2 , Ihh
Adrenal Cortex NeoplasmsGnai2
Adrenal Gland NeoplasmsPrkaca
Adrenocortical CarcinomaPik3ca
Advanced Sleep Phase Syndrome, Familial, 2Csnk1d
Advanced Sleep-Phase Syndrome, Familial, 1Csnk1d
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Agenesis of Corpus CallosumSin3a
Al Awadi SyndromeWnt7a
AlbuminuriaGpc5 , Lrp2
AlcoholismHdac2
Alopecia AreataHdac1 , Hdac2
Alzheimer DiseaseAkt1 , Bmp4 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Gsk3b , Hdac2 , Lrpap1 , Pik3r1
AmeloblastomaSmo
AmnesiaGnai1 , Gnai3
Amphetamine-Related DisordersAkt1 , Arrb2
Amyotrophic Lateral SclerosisAkt1 , Gsk3b
Amyotrophic Lateral Sclerosis 1Crebbp , Wnt7a
AnemiaBmp6
Angina, UnstableAkt1
AnodontiaGli3
Anorectal AnomaliesGli2
Anorectal AtresiaBmp4 , Gli2 , Gli3 , Shh
Anterior Segment Dysgenesis 5Ptch1
Anxiety DisordersGnb1 , Hdac2
Aortic Aneurysm, ThoracicTgfb2
Aortic Valve InsufficiencyTgfb2
Aortic Valve StenosisLgals3
Aortic Valve, Calcification ofAkt1
Arsenic PoisoningPias1
Arteriovenous FistulaArrb2
Arthritis, ExperimentalAkt1 , Arrb2 , Gli1 , Gsk3b , Lgals3 , Ptch1 , Shh , Smo
Arthritis, JuvenileMtss1
Arthritis, PsoriaticBmp4
Arthritis, RheumatoidBmp4 , Bmp6 , Grk2
AsthmaHdac2 , Kif3a , Lgals3
AstrocytomaAkt1
AtherosclerosisAkt1
Atrial FibrillationWnt8a
Atrioventricular BlockGnai2
Atrioventricular Septal DefectShh
Attention Deficit Disorder with HyperactivityCrebbp , Lgals3
Auriculo-condylar syndromeGnai3
Autism Spectrum DisorderIhh , Shh , Sin3a
Autistic DisorderWnt2
Autoimmune DiseasesTgfb2
Autoimmune Lymphoproliferative Syndrome, Type IIIPrkcd
Axenfeld-Rieger SyndromePtch1
Barrett EsophagusBmp4
Basal Cell Nevus SyndromeGli1 , Gli2 , Ptch1 , Shh , Smo , Sufu
Biliary AtresiaGli2 , Shh
Biliary Tract NeoplasmsPrkacb
Bipolar DisorderAkt1 , Gsk3b
Bladder ExstrophyWnt10a , Wnt11 , Wnt3 , Wnt6 , Wnt7a
bladder urothelial carcinomaAkt1 , Crebbp , Map2k1 , Pik3ca
Blindness, CorticalGnb1
Bone DiseasesBmp2
Bone Diseases, DevelopmentalKif3a , Tgfb2
Bone Diseases, MetabolicLrp2
Bone ResorptionBmp7 , Pthlh
BrachydactylyIhh
Brachydactyly Type A1Ihh , Shh
Brachydactyly Type A2Bmp2
Brachydactyly, Type E2Pthlh
BradycardiaGnai2
Brain InjuriesAkt1 , Bmp6 , Gsk3b , Pias1
Brain IschemiaAkt1 , Bmp6 , Lgals3 , Map2k1 , Prkaca , Prkacb , Prkcd
Brain NeoplasmsPtch1 , Smo
Breast AdenocarcinomaAkt1 , Pik3ca
Breast NeoplasmsAkt1 , Bmp2 , Bmp4 , Bmp6 , Bmp7 , Gnai2 , Hdac1 , Map2k1 , Pik3ca , Pik3r1 , Pthlh , Wnt10b , Wnt2 , Wnt7b , Wnt9a , Xpo1
BronchitisHdac2
Burkitt LymphomaPik3r1
BurnsGsk3b , Prkcd
CachexiaPthlh
CakutBmp7
CalcinosisBmp4
CarcinomaGnai2 , Pik3r1
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticCrebbp , Pik3ca , Wnt5b
Carcinoma, Basal CellGli2 , Hhip , Pik3ca , Ptch1 , Shh , Smo , Sufu
Carcinoma, Ductal, BreastAkt1 , Csnk1e
Carcinoma, EndometrioidAkt1 , Bmp4
Carcinoma, HepatocellularAkt1 , Crebbp , Gli1 , Gpc3 , Hdac2 , Hhip , Pik3ca , Shh
Carcinoma, Non-Small-Cell LungAkt1 , Map2k1 , Pik3ca , Pthlh
Carcinoma, Pancreatic DuctalHdac1 , Smo
Carcinoma, Renal CellAkt1 , Bmp4 , Bmp6 , Bmp7 , Map2k1 , Pik3ca , Wnt11
Carcinoma, Squamous CellAkt1 , Crebbp , Hdac1 , Hdac2 , Pik3ca
Carcinoma, Squamous Cell of Head and NeckAkt1 , Crebbp , Map2k1 , Pik3ca
Carcinoma, Transitional CellAkt1 , Crebbp , Map2k1 , Pik3ca
Cardiofaciocutaneous SyndromeMap2k1
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bmp4 , Grk2 , Gsk3b , Hdac2 , Prkcd
CardiomyopathiesAkt1 , Grk2
Cardiomyopathy, DilatedDhh
Cardiomyopathy, HypertrophicPrkaca
Cardiomyopathy, RestrictivePrkcd
Cardiovascular AbnormalitiesMap2k1
Cardiovascular DiseasesGrk2
Carotid Artery DiseasesHspg2
Carpenter Syndrome 1Rab23
Cartilage DiseasesBmp4
CataractMap2k1
Cell Transformation, NeoplasticLgals3 , Wnt5a
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b
Cervical Intraepithelial NeoplasiaHdac1 , Hdac2
CHARGE SyndromeBmp4
CholangiocarcinomaPrkaca , Prkacb
CholangitisTgfb2
ChondromaIhh , Smo
Choroidal NeovascularizationBmp4
Choroidal Neovascularization, ExperimentalSmo
Chronic Lymphoid LeukemiaXpo1
Cleft LipBmp4 , Ptch1
Cleft PalateGli3 , Gnb1 , Ptch1 , Shh , Tgfb2
ClubfootGli3
Cognition DisordersGsk3b , Hdac2 , Zic2
ColitisBmp6
colon cancerAkt1 , Pik3ca
Colonic NeoplasmsAkt1 , Gsk3b , Hdac1 , Hdac2 , Pik3ca , Pik3r1
Colonic PolypsHdac2
colorectal cancerAkt1 , Pik3ca
Colorectal NeoplasmsAkt1 , Bmp4 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Xpo1
Congenital AbnormalitiesGrk2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Coronary Artery DiseaseAkt1
Costello SyndromeMap2k1
COWDEN SYNDROME 5Pik3ca
Cranial Nerve InjuriesBmp4
Craniofacial AbnormalitiesCsnk1a1 , Gpc4 , Hspg2 , Kif3a , Lrp2 , Ptch1 , Sin3a , Tgfb2
CraniosynostosesBmp2
Craniosynostosis 7Bmp2
Crossed Polydactyly, Type IGli3
Culler-Jones SyndromeGli2
Currarino TriadPik3ca
CyanosisTgfb2
CyclopiaDisp1 , Ptch1
DementiaLrpap1
Demyelinating DiseasesHdac1 , Ptch1 , Shh
Depressive DisorderGnb1 , Gsk3b
Dermatitis, Allergic ContactBmp6 , Grk2
Developmental DisabilitiesGnb1 , Lrp2
Diabetes Mellitus, ExperimentalAkt1 , Foxa2 , Hdac1 , Hdac2 , Hspg2 , Lgals3 , Lrp2 , Pik3r1 , Prkcd , Tgfb2
Diabetes Mellitus, Type 1Hdac1 , Hdac2 , Lgals3
Diabetes Mellitus, Type 2Akt1 , Foxa2 , Gsk3b , Hdac1 , Hdac2 , Pik3r1
Diabetic NephropathiesBmp7 , Hdac2
Diabetic NeuropathiesHhip , Tgfb2
Disease Models, AnimalAkt1 , Wnt11
Donnai-Barrow SyndromeLrp2
Drug-Induced Liver InjuryLgals3
DwarfismSin3a , Wnt4
Dyssegmental dysplasiaHspg2
DystoniaGnb1
EctromeliaWnt3
EdemaPthlh
Embryo LossGrk2
Encephalomyelitis, Autoimmune, ExperimentalGli1 , Shh , Tgfb2
Endodermal Sinus TumorWnt2b
Endometrial NeoplasmsHdac1 , Hdac2 , Pik3ca , Spop , Wnt2 , Wnt3 , Wnt4 , Wnt5a
EndometriosisBmp7 , Hdac1 , Hdac2 , Ihh , Tgfb2
Epidermal NevusPik3ca
EpilepsyAkt1 , Bmp4 , Gnb1
Epilepsy, Temporal LobeHdac2 , Shh
Epilepsy, Tonic-ClonicGnb1
Epileptic Encephalopathy, Early Infantile, 17Gnao1
Erectile DysfunctionAkt1
Esophageal Atresia with or without Tracheoesophageal FistulaGli2 , Gli3 , Shh
Esophageal NeoplasmsLgals3 , Pik3ca
Esophageal Squamous Cell CarcinomaBmp6 , Crebbp
EsophagitisBmp4
Esophagitis, PepticBmp4
Eye AbnormalitiesShh , Tgfb2
Eye Diseases, HereditaryLrp2
Facial AsymmetryPik3ca
Failure to ThriveGnb1
Familial Primary Pulmonary HypertensionHdac1
Familial SchizencephalyShh
Fatty LiverPrkcd
Female Urogenital DiseasesWnt4 , Wnt5a , Wnt7a
Femoral FracturesBmp4 , Bmp7
Fetal Growth RetardationBmp4 , Hdac1 , Hdac2 , Sin3a
FibroadenomaWnt2 , Wnt4
FibrosisAkt1
Fluoride PoisoningGli1 , Shh , Smo
Focal Cortical Dysplasia of TaylorBmp4
Foot Deformities, CongenitalPthlh
Fractures, BoneBmp2 , Bmp7
Fractures, CartilageBmp4
Fuhrmann SyndromeWnt7a
Gastrointestinal NeoplasmsPik3ca
Genetic Diseases, InbornCrebbp , Gli2 , Gnao1 , Gnb1 , Hdac1 , Ptch1 , Stil , Wnt10a
GlaucomaCrebbp , Tgfb2
GlioblastomaAkt1 , Crebbp , Pik3ca , Pik3r1
GliomaLgals3 , Pik3ca
GliosisBmp4 , Bmp7
Glomerulonephritis, IGAShh
Glomerulonephritis, MembranousLrp2 , Lrpap1 , Shh
Glomerulosclerosis, Focal SegmentalPias1 , Shh
Gonadal Dysgenesis, 46,XYDhh
Granulosa Cell TumorBmp4 , Gnai2
Granulosa Cell Tumor of the OvaryGnai2
Greig cephalopolysyndactyly syndromeGli3
Growth DisordersPik3ca , Pthlh
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Hand Deformities, CongenitalPthlh
Head and Neck NeoplasmsPik3ca
Hearing LossBmp4
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, SensorineuralLrp2
Heart ArrestAkt1
Heart Defects, CongenitalPtch1 , Tgfb2
Heart DiseasesHdac1
Heart FailureGrk2 , Gsk3b , Lgals3 , Prkaca
HemimegalencephalyPik3ca
HemochromatosisBmp2 , Bmp6
Hernia, DiaphragmaticBmp4 , Foxa2 , Lrp2
Hernias, Diaphragmatic, CongenitalBmp4 , Wnt11
High MyopiaLrp2
Hirschsprung DiseaseShh , Wnt8b
Hirschsprung Disease 1Crebbp , Ptch1
HIV InfectionsPtch1
HoloprosencephalyCdon , Disp1 , Gli2 , Ptch1 , Shh , Sufu , Zic2
Holoprosencephaly 11Cdon
Holoprosencephaly 3Shh
Holoprosencephaly 5Zic2
Holoprosencephaly 7Ptch1
Holoprosencephaly 9Gli2
Holt-Oram SyndromeTgfb2
Huntington DiseaseHdac1 , Sin3a
HydrocephalusSin3a
HyperalgesiaPthlh , Sin3a
HypercalcemiaPthlh
HyperglycemiaGrk2 , Hspg2 , Ptch1
HyperinsulinismFoxa2 , Prkcd
HyperoxiaBmp4
Hyperoxic Lung InjuryPtch1 , Shh
HyperplasiaAkt1 , Pik3ca
HypertensionAkt1 , Grk2 , Gsk3b , Hspg2 , Lgals3 , Lrp2 , Pik3r1 , Prkcd
Hypertension, PortalGrk2 , Pik3r1 , Prkcd
Hypertension, PulmonaryHdac1 , Hdac2
Hypertrophy, Left VentricularGrk2 , Prkcd
Hypertrophy, Right VentricularAkt1 , Hdac1 , Prkcd
Hypoglossal Nerve InjuriesPrkaca , Prkacb
HypoglycemiaPik3r1
HypopigmentationGli3
HypospadiasGli3
Hypothalamic HamartomasGli3
HypothyroidismGnb1 , Shh , Wnt3a
Hypoxia-Ischemia, BrainBmp4
Immunodeficiency 36Pik3r1
Infarction, Middle Cerebral ArteryShh , Smo
InflammationAkt1
Insulin ResistanceGrk2 , Pik3r1 , Prkcd
Intellectual DisabilityGnb1 , Sin3a
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsGsk3b , Prkcd
Intestinal PolyposisGli3
Ischemic Attack, TransientSin3a
Jaw AbnormalitiesSmo
Joubert SyndromeIft172
Joubert Syndrome 1Ift172
KeratoconusBmp4
Keratoderma, PalmoplantarWnt10a
Keratosis, SeborrheicPik3ca
Kidney DiseasesBmp7 , Lrp2 , Wnt4
Kidney Failure, ChronicLrp2
Kidney NeoplasmsAkt1
Kidney Reperfusion InjuryLgals3 , Shh
Kidney Tubular Necrosis, AcuteBmp7
Language Development DisordersHdac2
LeiomyomaWnt5b , Wnt7a
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellXpo1
Leukemia, MyeloidHdac2
Leukemia, Myeloid, AcuteCrebbp
Leukemia, Promyelocytic, AcuteAkt1 , Gli1 , Gli2 , Smo
Leukemia-Lymphoma, Adult T-CellBmp6 , Csnk1a1
Lichen Planus, OralBmp4
Limb Deformities, CongenitalBmp4 , Shh , Tgfb2
Liver CirrhosisHdac2 , Hhip , Lgals3
Liver Cirrhosis, BiliaryHhip
Liver Cirrhosis, ExperimentalArrb2 , Bmp4 , Bmp7 , Foxa2 , Gnai2 , Grk2 , Lgals3 , Prkcd
Liver NeoplasmsAkt1 , Crebbp , Ift88 , Pik3ca
Liver Neoplasms, ExperimentalArrb2 , Map2k1
Loeys-Dietz SyndromeTgfb2
Loeys-Dietz Syndrome 4Tgfb2
lung cancerPik3ca
Lung DiseasesFoxa2 , Pthlh
Lung NeoplasmsAkt1 , Pik3ca , Wnt5a
Lymphatic MetastasisPik3ca
Lymphoma, FollicularCrebbp
Lymphoma, Large B-Cell, DiffuseGli1 , Pik3ca
Lymphoma, Mantle-CellGsk3b , Wnt10a , Wnt3
Lymphoma, Non-HodgkinMap2k1 , Pik3ca
Lymphoma, T-CellAkt1
Macular DegenerationBmp4
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalGnai2 , Pik3r1 , Wnt1 , Wnt3 , Wnt6
Mammary Neoplasms, ExperimentalAkt1 , Gnai2 , Pik3r1 , Wnt1 , Wnt2 , Wnt3 , Wnt3a , Wnt5b , Wnt6 , Wnt7a , Wnt7b
Mandibular FracturesIhh
Marijuana AbuseAkt1
Maxillary NeoplasmsSmo
MedulloblastomaCrebbp , Pik3ca , Ptch1 , Smo , Sufu
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
MegalencephalyGli3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
MelanomaAkt1 , Bmp4 , Crebbp , Hdac2 , Lgals3 , Map2k1 , Pik3ca , Pik3r1 , Rab23 , Sufu
Memory DisordersHdac2
Meningeal NeoplasmsAkt1
MeningiomaAkt1 , Smo
Meningioma, FamilialSufu
Meningitis, PneumococcalLgals3
MesotheliomaGpc3
Mesothelioma, MalignantTgfb2 , Wnt3
Metabolic Syndrome XLrpap1
Methylmalonic Aciduria due to Methylmalonyl-CoA Mutase DeficiencyPtch1
MicrocephalyGli2 , Sin3a , Stil
Microcephaly, Primary Autosomal Recessive, 7Stil
Microphthalmia, Isolated, with Coloboma 5Shh
Microphthalmia, Syndromic 1Gli2 , Ift172 , Ptch1 , Wnt7a
Microphthalmia, Syndromic 6Bmp4
Microsatellite InstabilityHdac2
Mixed Tumor, MullerianPik3ca , Pik3r1
Mood DisordersAkt1
Mouth NeoplasmsPik3ca
Mullerian Aplasia and HyperandrogenismWnt4
Multiple MyelomaPik3ca , Pthlh
Multiple SclerosisGli1 , Hdac1 , Shh
Multiple Sclerosis, Chronic ProgressiveShh
Muscle HypotoniaGnb1 , Hdac2
Muscular AtrophyAkt1 , Gsk3b
Muscular DiseasesPrkcd
Musculoskeletal AbnormalitiesTgfb2
Myelodysplastic SyndromesGnb1
Myocardial InfarctionAkt1 , Gsk3b , Lrpap1 , Shh , Tgfb2
Myocardial IschemiaPrkcd
Myocardial Reperfusion InjuryAkt1 , Gsk3b , Prkcd , Shh
MyopiaBmp2
Myopia 23, Autosomal RecessiveLrpap1
Myositis OssificansBmp4
Myositis, Inclusion BodyCsnk1a1
Nasopharyngeal CarcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
NecrosisLgals3
Nematode InfectionsPik3r1
NeointimaLgals3
Neoplasm MetastasisBmp6 , Bmp7 , Lgals3
Neoplasm Recurrence, LocalGnai2
NeoplasmsMap2k1 , Pik3ca , Pik3r1
Neoplastic Syndromes, HereditaryPik3ca , Ptch1
NephritisLgals3
NephrosisLrp2
Nephrotic SyndromeGpc5
Neural Tube DefectsGli3 , Zic2
NeuroblastomaPik3ca
NEURODEVELOPMENTAL DISORDER WITH INVOLUNTARY MOVEMENTSGnao1
Neuroectodermal Tumors, PrimitivePtch1 , Smo
Neuroendocrine TumorsPthlh
Neurotoxicity SyndromesPrkcd
Noonan SyndromeMap2k1
ObesityAkt1 , Foxa2 , Pik3r1 , Prkcd , Wnt10b
Ocular HypertensionBmp4 , Gli1 , Shh , Smo
Odontoonychodermal DysplasiaWnt10a
Orofacial CleftBmp4
Orofacial Cleft 11Bmp4
Osseous Heteroplasia, ProgressiveBmp4
Ossification of the Posterior Longitudinal Ligament of the SpineBmp4
OsteoarthritisBmp2 , Bmp4 , Bmp6 , Ihh
Osteoarthritis, ExperimentalBmp4 , Lrpap1
OsteochondrodysplasiasHspg2 , Tgfb2
Osteogenesis Imperfecta, Type XVWnt1
OsteolysisPthlh
OsteoporosisBmp2
OsteosarcomaAkt1
OtosclerosisBmp2 , Bmp4
Ovarian CystsIhh
Ovarian Epithelial CancerPik3ca , Wnt4
Ovarian NeoplasmsAkt1 , Bmp7 , Hdac1 , Hdac2 , Map2k1 , Pik3ca , Pik3r1 , Wnt7a
PainAkt1
Pallister-Hall SyndromeGli3
Pallister-Hall Syndrome 2Gli2
Pancreatic AdenocarcinomaPik3ca
Pancreatic Intraepithelial NeoplasiaHdac1
Pancreatic NeoplasmsBoc , Gli1 , Gli3 , Lrp2 , Ptch1 , Pthlh , Shh , Smo , Wnt9a
PancreatitisSmo
Pancreatitis, Acute NecrotizingPthlh
Pancreatitis, AlcoholicPthlh
Pancreatitis, ChronicPthlh
Pancreatitis, Experimental, Chronic Gli1 , Ptch1 , Smo
papillary renal cell carcinoma Pik3ca
Papillary Renal Cell Carcinoma, SporadicPik3ca
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Grk2 , Gsk3b
Parkinson Disease, SecondaryShh
Parkinsonian DisordersPrkcd , Shh
Patterson Stevenson SyndromeShh
Penile IndurationHdac2
Penile NeoplasmsPik3ca
Peripheral Arterial DiseaseBmp2 , Bmp8a
Peripheral Nerve InjuriesHhip , Shh
Peripheral Nervous System DiseasesGli1
PeritonitisGsk3b
Persistent CloacaShh
PiebaldismGli3
Pigmented Nodular Adrenocortical Disease, Primary, 4Prkaca
Pituitary ACTH HypersecretionGnai2
Pleomorphic Xanthoastrocytoma Gli3 , Gnai1 , Gpc2 , Smo , Wnt16 , Wnt2
PoisoningGsk3b
Polycystic Kidney, Autosomal DominantLrp2
Polycystic Kidney, Autosomal RecessiveAkt1 , Ift88 , Pik3ca
PolydactylyGli3 , Ift88 , Kif3a , Shh
Polydactyly, PostaxialGli3
Polydactyly, Preaxial 4Gli3
Polydactyly, Preaxial IIShh
Precancerous ConditionsAkt1 , Ift88
Precursor Cell Lymphoblastic Leukemia-LymphomaCrebbp , Gnb1 , Hdac1 , Hdac2
Primary Hyperoxaluria Type 1Gpc1
ProlactinomaBmp4 , Lrp2
Prostatic Intraepithelial NeoplasiaHdac1
Prostatic NeoplasmsAkt1 , Bmp2 , Bmp4 , Bmp6 , Bmp7 , Crebbp , Gli1 , Gsk3b , Hdac1 , Hdac2 , Lrp2 , Lrpap1 , Map2k1 , Pik3ca , Pik3r1 , Prkacb , Pthlh , Spop , Sufu , Wnt11 , Wnt2 , Wnt4 , Zic2
Proteus SyndromeAkt1
Psychoses, Substance-InducedAkt1
Pulmonary Disease, Chronic ObstructiveHdac2 , Hhip
Pulmonary EmphysemaHdac2 , Hhip
Pulmonary FibrosisBmp7
PyelonephritisBmp7
RASopathiesMap2k1
Rectal NeoplasmsPik3ca
Renal FibrosisBmp6
Renal Insufficiency, ChronicShh
Reperfusion InjuryAkt1 , Bmp6 , Pik3r1 , Wnt3a
Respiratory System AbnormalitiesTgfb2
Retina Reperfusion InjuryHdac2
Retinitis Pigmentosa 71Ift172
Retinopathy of PrematurityIhh
RhabdomyosarcomaPtch1
Robinow Syndrome, Autosomal DominantWnt5a
Rubinstein-Taybi SyndromeCrebbp
Salivary Gland NeoplasmsWnt5b
SarcomaPik3ca
Schistosomiasis MansoniIhh
SchizencephalyShh
SchizophreniaAkt1 , Gnaz , Gsk3b , Xpo1
Schizophrenia, ChildhoodHspg2
Schopf-Schulz-Passarge SyndromeWnt10a
ScoliosisCrebbp
SeizuresGnai1 , Gnb1 , Hdac2 , Prkcd , Smo , Wnt2
SepsisGrk2 , Gsk3b
Septic PeritonitisPik3r1
Septo-Optic DysplasiaCdon
Sezary SyndromeCrebbp
SHORT SyndromePik3r1
Short-Rib Thoracic Dysplasia 10 with or without PolydactylyIft172
Simpson-Golabi-Behmel SyndromeGpc3 , Gpc4
Single Upper Central IncisorShh
Skin DiseasesPias1
Skin NeoplasmsAkt1 , Gli2 , Ptch1 , Smo
Skull FracturesBmp4
Small Cell Lung CarcinomaAkt1 , Crebbp , Pik3ca
Smith-Magenis SyndromeCsnk1d , Spop , Wnt3 , Wnt9b
Spinal Cord InjuriesAkt1 , Bmp2 , Bmp4 , Shh , Tgfb2
Spinal DysraphismGli1 , Gli2 , Ptch1
Split-Hand/Foot Malformation 6Wnt10b
Squamous Cell Carcinoma of the LungAkt1 , Crebbp , Pik3ca
Status EpilepticusGsk3b
Stomach NeoplasmsBmp2 , Bmp7 , Gli3 , Hdac2 , Lgals3 , Mtss1 , Pik3ca
StrabismusBmp4 , Gnb1
StrokeAkt1 , Bmp4 , Hdac1 , Hdac2 , Prkcd
Subarachnoid HemorrhageGli1 , Ptch1 , Shh
Substance Withdrawal SyndromeGnai1 , Gnao1
Superior Vena Cava SyndromePthlh
SyndactylyGli3
Syndactyly, Type IIhh
Syndactyly, Type IVShh
Tachycardia, VentricularGnai2
TauopathiesGsk3b , Hdac1
TeratomaWnt2b
Tetra-Amelia Autosomal RecessiveWnt3
ThecomaGnai2
Thumb DeformityCrebbp
Thyroiditis, AutoimmuneLrp2
Tibial FracturesBmp2 , Bmp4 , Bmp6 , Bmp7
Tooth Agenesis, Selective, 4Wnt10a
TOOTH AGENESIS, SELECTIVE, 8Wnt10b
Tracheoesophageal FistulaBmp4
Tuberous SclerosisBmp4
UremiaBmp2
Ureteral ObstructionAkt1 , Shh , Tgfb2
Urinary Bladder NeoplasmsAkt1 , Crebbp , Gli1 , Wnt7b
Urogenital AbnormalitiesTgfb2 , Wnt4
Urogenital NeoplasmsWnt7a
Urologic NeoplasmsWnt2
Uterine Cervical NeoplasmsAkt1 , Crebbp , Hdac1 , Hdac2 , Pik3ca , Wnt2 , Wnt5a
Uterine NeoplasmsMap2k1 , Pik3ca , Pik3r1 , Spop , Xpo1
VACTERL/VATER AssociationShh
Vascular MalformationsPik3ca
Ventilator-Induced Lung InjuryAkt1
Ventricular Tachycardia, FamilialGnai2
Vitamin A DeficiencyBmp4
Vitamin D DeficiencyLrp2
Wallerian DegenerationTgfb2
Weight GainPik3ca
Wilms TumorBmp7 , Gpc3 , Gpc4
Winter Shortland Temple SyndromeSmo
Wounds and InjuriesTgfb2
X-Linked Infantile Spasm SyndromeGnao1
Pathway Annotations Associated with Genes in the Hedgehog signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca
acetylcholine signaling pathway via muscarinic acetylcholine receptorGrk2
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein familyGnai1 , Gnai2
acute myeloid leukemia pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
adenosine signaling pathwayAkt1 , Gnb1 , Pik3ca , Prkacb
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca
aldosterone signaling pathwayCrebbp , Pias1 , Pik3ca , Pik3r1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1
altered Hedgehog signaling pathwayBoc , Dhh , Gli1 , Gli3 , Lrp2 , Ptch1 , Shh , Smo
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Pik3ca
altered Wnt signaling, canonical pathwayWnt9a
Alzheimer disease pathwayGsk3b
amiodarone pharmacodynamics pathwayPrkaca
amlodipine pharmacodynamics pathwayPrkaca
androgen signaling pathwayCrebbp
angiotensin II signaling pathway via AT1 receptorArrb2 , Grk2
angiotensin II signaling pathway via AT2 receptorGnai2 , Gnai3
apoptotic cell death pathwayAkt1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
atenolol pharmacodynamics pathwayPrkaca
B cell receptor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
basal cell carcinoma pathwayBmp2 , Bmp4 , Gli1 , Gli2 , Gli3 , Gsk3b , Hhip , Ptch1 , Shh , Smo , Stk36 , Sufu , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
betaxolol pharmacodynamics pathwayPrkaca
bile acid transport pathwayPrkaca , Prkacb , Prkx
bisoprolol pharmacodynamics pathwayPrkaca
bladder cancer pathwayMap2k1
Bone morphogenetic proteins signaling pathwayBmp2 , Bmp4 , Bmp6 , Bmp7 , Gsk3b
bupranolol drug pathwayPrkaca
bupranolol pharmacodynamics pathwayPrkaca
calcium signaling pathway via the calcium-sensing receptorArrb2 , Grk2
calcium/calcium-mediated signaling pathwayPrkaca , Prkacb , Prkx
carvedilol pharmacodynamics pathwayPrkaca
cell cycle pathway, mitoticCrebbp , Gsk3b , Hdac1 , Hdac2 , Tgfb2
ceramide signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd , Tgfb2
CHD family mediated chromatin remodeling pathwayHdac1 , Hdac2 , Rbbp4 , Rbbp7
chemokine mediated signaling pathwayAkt1 , Arrb2 , Gnai1 , Gnai2 , Gnai3 , Gnb1 , Gng2 , Grk2 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkcd , Prkx
chronic myeloid leukemia pathwayAkt1 , Hdac1 , Hdac2 , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
colorectal cancer pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
CRM1 export pathwayXpo1
cytokine mediated signaling pathwayTgfb2
dilated cardiomyopathy pathwayPrkaca , Prkacb , Prkx , Tgfb2
diltiazem pharmacodynamics pathwayPrkaca
disopyramide pharmacodynamics pathwayPrkaca
DNA modification pathwaySin3a
dobutamine pharmacodynamics pathwayPrkaca
dopamine signaling pathwayCsnk1a1 , Prkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsArrb2 , Gnb1 , Grk2 , Prkacb
dopamine signaling pathway via D2 family of receptorsArrb2 , Gnai2 , Gnao1 , Grk2
E-cadherin signaling pathwayAkt1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Arrb2 , Gnai2 , Gnb1 , Gng2 , Grk2 , Prkaca , Prkcd
endocytosis pathwayArrb2 , Grk2 , Tgfb2
endometrial cancer pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
endothelin signaling pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Map2k1 , Prkcd
Entamoeba histolyca infection pathwayPik3ca , Pik3r1 , Prkaca , Prkacb , Prkx , Tgfb2
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Gnai1 , Gnai3 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
epinephrine signaling pathway via adrenergic receptor betaArrb2 , Grk2
erythropoietin signaling pathwayPik3r1
esmolol pharmacodynamics pathwayPrkaca
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd
Fc gamma receptor mediated signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1 , Prkcd
fibroblast growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayPrkaca
follicle-stimulating hormone signaling pathwayGnb1 , Prkacb
forkhead class A signaling pathwayAkt1 , Crebbp , Foxa2 , Shh
fosphenytoin pharmacodynamics pathwayPrkaca
G protein mediated signaling pathwayGnao1
G protein mediated signaling pathway via Galpha12/Galpha13 familyGnb1
G protein mediated signaling pathway via Galphai familyGnai1 , Gnai2 , Gnai3 , Gnao1
G protein mediated signaling pathway via Galphas familyGrk2
glioma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
glutamate signaling pathwayGnai1 , Gnai2 , Gnai3 , Gnao1 , Gnb1 , Gng2 , Grk2 , Prkaca , Prkacb , Prkx
glycogen biosynthetic pathwayGsk3b
glypican signaling pathwayBmp4 , Gpc1 , Gpc2 , Gpc3 , Ptch1 , Shh , Tgfb2
gonadotropin-releasing hormone signaling pathwayMap2k1 , Prkaca , Prkacb , Prkcd , Prkx
granulocyte-macrophage colony-stimulating factor signaling pathwayMap2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb
Hedgehog signaling pathwayAkt1 , Arrb2 , Bmp2 , Bmp4 , Bmp5 , Bmp6 , Bmp7 , Bmp8a , Boc , Btrc , Cdon , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Dhh , Disp1 , Fbxw11 , Foxa2 , Gli1 , Gli2 , Gli3 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Gnb1 , Gng2 , Gpc1 , Gpc2 , Gpc3 , Gpc4 , Gpc5 , Grk2 , Gsk3b , Hdac1 , Hdac2 , Hhat , Hhip , Hspg2 , Ift172 , Ift88 , Ihh , Kif3a , Lgals3 , Lrp2 , Lrpap1 , Map2k1 , Mtss1 , Pias1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkcd , Prkx , Ptch1 , Pthlh , Rab23 , Rbbp4 , Rbbp7 , Shh , Sin3a , Smo , Spop , Sspo , Stil , Stk36 , Sufu , Tgfb2 , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b , Xpo1 , Zic2
hepatitis C virus infection pathwayAkt1 , Gsk3b , Pias1 , Pik3ca , Pik3r1
histamine signaling pathway, immunologicalGnb1 , Prkacb
histone modification pathwayCrebbp , Hdac1 , Hdac2 , Rbbp4 , Rbbp7
Huntington disease pathwayCrebbp , Hdac1 , Hdac2 , Sin3a
hypertrophic cardiomyopathy pathwayTgfb2
hypoxia inducible factor pathwayAkt1 , Crebbp
ibutilide pharmacodynamics pathwayPrkaca
influenza A virus infection pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Xpo1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Gsk3b , Kif3a
insulin signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkacb , Prkx
insulin-like growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1 , Prkcd
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayMap2k1 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayHdac1 , Pik3ca , Pik3r1 , Prkaca , Prkacb
interleukin-4 signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
isoprenaline pharmacodynamics pathwayPrkaca
isradipine pharmacodynamics pathwayPrkaca
ISWI family mediated chromatin remodeling pathwayRbbp4 , Rbbp7
Jak-Stat signaling pathwayAkt1 , Crebbp , Pias1 , Pik3ca , Pik3r1
kinin signaling pathwayArrb2
Leishmania infection pathwayTgfb2
levobunolol pharmacodynamics pathwayPrkaca
lidocaine pharmacodynamics pathwayPrkaca
long term depressionGnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz , Gsk3b , Map2k1
long term potentiationCrebbp , Map2k1 , Prkaca , Prkacb , Prkx
luteinizing hormone signaling pathwayGnb1 , Prkacb
maturity onset diabetes of the young pathwayFoxa2
measles infection pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
melanocortin system pathwayGnb1 , Prkacb
melanoma pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
metoprolol pharmacodynamics pathwayPrkaca
mexiletine pharmacodynamics pathwayPrkaca
mitogen activated protein kinase signaling pathwayAkt1 , Arrb2 , Map2k1 , Prkaca , Prkacb , Prkx , Tgfb2
mTOR signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Sspo
Mycobacterium tuberculosis infection pathwayAkt1 , Crebbp , Tgfb2
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayPrkaca
nebivolol pharmacodynamics pathwayPrkaca
neurotrophic factor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1 , Prkcd
nifedipine pharmacodynamics pathwayPrkaca
nimodipine pharmacodynamics pathwayPrkaca
nisoldipine pharmacodynamics pathwayPrkaca
nitrendipine pharmacodynamics pathwayPrkaca
non-small cell lung cancer pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
Notch signaling pathwayCrebbp , Hdac1 , Hdac2 , Sspo
nuclear factor kappa B signaling pathwayArrb2 , Btrc , Pik3ca , Pik3r1 , Sspo , Xpo1
nuclear factor, erythroid 2 like 2 signaling pathwayBtrc , Crebbp , Gsk3b
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnai1
p38 MAPK signaling pathwayCdon
p53 signaling pathwayAkt1 , Crebbp , Csnk1a1 , Csnk1d , Csnk1e , Csnk1g1 , Csnk1g2 , Csnk1g3 , Gsk3b , Hdac1 , Prkcd
pancreatic cancer pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
parathyroid hormone signaling pathwayArrb2 , Grk2
penbutolol pharmacodynamics pathwayPrkaca
phenytoin pharmacodynamics pathwayPrkaca
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1 , Prkaca
phosphoinositide metabolic pathwayPik3ca , Pik3r1
pindolol pharmacodynamics pathwayPrkaca
Plasmodium infection pathwayTgfb2
platelet-derived growth factor signaling pathwayMap2k1 , Pik3ca , Pik3r1 , Prkcd
prion diseases pathwayMap2k1 , Prkaca , Prkacb , Prkx
procainamide pharmacodynamics pathwayPrkaca
propranolol pharmacodynamics pathwayPrkaca
prostaglandin D2 signaling pathwayGnb1 , Prkacb
prostaglandin I2 signaling pathwayGnb1 , Prkacb
prostate cancer pathwayAkt1 , Crebbp , Gsk3b , Map2k1 , Pik3ca , Pik3r1
protein kinase A (PKA) signaling pathwayPrkaca , Prkacb
protein kinase C (PKC) signaling pathwayPrkcd
quinidine pharmacodynamics pathwayPrkaca
Reelin signaling pathwayAkt1 , Gsk3b , Lrpap1 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
rheumatoid arthritis disease pathwayTgfb2
ribosome biogenesis pathwayCsnk1d , Csnk1e , Xpo1
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayXpo1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
serotonin signaling pathway via receptors engaging G alphas protein familyGnb1 , Prkacb
small cell lung cancer pathwayAkt1 , Pias1 , Pik3ca , Pik3r1
sotalol pharmacodynamics pathwayPrkaca
sphingosine 1-phosphate signaling pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Gnaz
syndecan signaling pathwayPrkaca , Prkcd
T cell receptor signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1 , Prkcd
the Wnt/calcium signaling pathwayWnt11
thyroid cancer pathwayMap2k1
timolol pharmacodynamics pathwayPrkaca
Toll-like receptor signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
Toxoplasma gondii infection pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Pik3ca , Pik3r1 , Tgfb2
Trail mediated signaling pathwayPik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayArrb2 , Crebbp , Tgfb2
transforming growth factor-beta superfamily mediated signaling pathwayBmp2 , Bmp4 , Bmp5 , Bmp6 , Bmp7 , Bmp8a , Crebbp , Tgfb2
Trypanosoma cruzi infection pathwayAkt1 , Gnai1 , Gnai2 , Gnai3 , Gnao1 , Pik3ca , Pik3r1 , Tgfb2
type 2 diabetes mellitus pathwayPik3ca , Pik3r1 , Prkcd
type II interferon signaling pathwayAkt1 , Crebbp , Map2k1 , Pias1 , Pik3ca , Pik3r1 , Prkcd
ubiquitin/proteasome degradation pathwayBtrc , Fbxw11 , Pias1
vascular endothelial growth factor signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Prkaca , Prkcd
vasopressin signaling pathway via receptor type 2Gnb1 , Prkaca , Prkacb , Prkx
verapamil pharmacodynamics pathwayPrkaca
visual phototransduction pathwayArrb2 , Gnb1
Wnt signaling pathwayBtrc , Crebbp , Csnk1a1 , Csnk1e , Fbxw11 , Gsk3b , Prkaca , Prkacb , Prkx , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, canonical pathwayBtrc , Crebbp , Csnk1a1 , Csnk1g1 , Gsk3b , Wnt1 , Wnt10a , Wnt10b , Wnt11 , Wnt16 , Wnt2 , Wnt2b , Wnt3 , Wnt3a , Wnt4 , Wnt5a , Wnt5b , Wnt6 , Wnt7a , Wnt7b , Wnt8a , Wnt8b , Wnt9a , Wnt9b
Wnt signaling, non-canonical pathwayArrb2 , Csnk1a1 , Wnt5a , Wnt7a
Wnt signaling, the planar cell polarity pathwayWnt7b
Phenotype Annotations Associated with Genes in the Hedgehog signaling pathway

References Associated with the Hedgehog signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: