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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3171 Species: Rattus norvegicus RGD Object: Gene Symbol: Nfkbia Name: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Acc ID: CHEBI:21759 Term: N-methyl-N'-nitro-N-nitrosoguanidine Definition: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position CasRN: 70-25-7 Chemical ID: MESH:D008769

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA] Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein] Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form]	PMID:19851710
decreases expression	EXP		6480464	CTD	Methylnitronitrosoguanidine results in decreased expression of NFKBIA mRNA Methylnitronitrosoguanidine results in decreased expression of NFKBIA protein	PMID:19851710
increases expression	EXP		6480464	CTD	Methylnitronitrosoguanidine results in increased expression of NFKBIA protein modified form	PMID:19851710
multiple interactions	ISO	RGD:735440	6480464	CTD	Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased degradation of NFKBIA protein	PMID:22001597