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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lithocholic acid
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Accession:CHEBI:16325 term browser browse the term
Definition:A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Synonyms:exact_synonym: 3alpha-hydroxy-5beta-cholan-24-oic acid
 related_synonym: (3alpha,5beta)-3-hydroxycholan-24-oic acid;   3alpha-Hydroxy-5beta-cholanate;   3alpha-hydroxy-5beta-cholanic acid;   3alpha-hydroxy-5beta-cholanoic acid;   5beta-cholanic acid-3alpha-ol;   Formula=C24H40O3;   InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1;   InChIKey=SMEROWZSTRWXGI-HVATVPOCSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@H](O)C2
 alt_id: CHEBI:1711;   CHEBI:20238;   CHEBI:20239
 xref: Beilstein:3217757;   CAS:434-13-9;   HMDB:HMDB0000761;   KEGG:C03990;   LINCS:LSM-5371;   LIPID_MAPS_instance:LMST04010003
 xref_mesh: MESH:D008095
 xref: MetaCyc:CPD-7235;   PDBeChem:4OA;   PMID:20622262;   PMID:23639599;   PMID:24270587;   PMID:24332653;   PMID:24399466;   PMID:7068113;   Reaxys:3217757;   Wikipedia:Lithocholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:29744


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lithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
increases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of ABCA1 mRNA; Lithocholic Acid results in decreased expression of ABCA1 protein
Lithocholic Acid results in increased expression of ABCA1 mRNA
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]		 CTD PMID:15883047 PMID:20977460 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
decreases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of ABCB11 mRNA
Lithocholic Acid results in decreased expression of ABCB11 mRNA
Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA]
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA		 CTD PMID:17256725 PMID:17963371 PMID:20359477 PMID:20977460 PMID:23034213 More... NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of ABCB1 mRNA
VDR protein promotes the reaction [Lithocholic Acid results in increased expression of ABCB1 mRNA]		 CTD PMID:19460946 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression ISO Lithocholic Acid results in increased expression of ABCB1B mRNA CTD PMID:20977460 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Lithocholic Acid results in increased expression of ABCB4 mRNA CTD PMID:20359477 PMID:25582706 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of ABCC1 mRNA; Lithocholic Acid results in increased expression of ABCC1 protein
Lithocholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]		 CTD PMID:16101123 PMID:18032408 PMID:20977460 PMID:23034213 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
affects localization
multiple interactions		 ISO
EXP		 Lithocholic Acid results in increased expression of ABCC2 mRNA
Lithocholic Acid results in increased expression of ABCC2 mRNA; Lithocholic Acid results in increased expression of ABCC2 protein
Lithocholic Acid affects the localization of ABCC2 protein
[Cyclosporine results in decreased activity of ABCC2 protein] which results in increased abundance of Lithocholic Acid; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA
[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA
[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]		 CTD PMID:14570758 PMID:16436656 PMID:18032408 PMID:20888898 PMID:20977460 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
decreases expression
increases expression
increases activity		 ISO [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC3 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]
Lithocholic Acid results in decreased expression of ABCC3 mRNA
Lithocholic Acid results in increased activity of ABCC3 protein
[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA
Lithocholic Acid results in increased expression of ABCC3 mRNA; Lithocholic Acid results in increased expression of ABCC3 protein		 CTD PMID:14570758 PMID:15358766 PMID:15824121 PMID:16436656 PMID:18032408 More... NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
decreases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of ABCC4 mRNA
Lithocholic Acid results in decreased expression of ABCC4 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC4 protein; [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]		 CTD PMID:17256725 PMID:18032408 PMID:20977460 PMID:23034213 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression		 ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]
Lithocholic Acid results in increased expression of ABCC5 mRNA; Lithocholic Acid results in increased expression of ABCC5 protein		 CTD PMID:18032408 PMID:20977460 PMID:23034213 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression ISO Lithocholic Acid results in decreased expression of ABCC6 protein CTD PMID:18032408 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression		 ISO NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA] CTD PMID:20977460 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions
increases expression		 ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA
Lithocholic Acid results in increased expression of ABCG5 mRNA		 CTD PMID:20359477 PMID:25055961 PMID:25582706 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression
increases expression		 ISO Lithocholic Acid results in decreased expression of ABCG8 mRNA
Lithocholic Acid results in increased expression of ABCG8 mRNA		 CTD PMID:20359477 PMID:25582706 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACACA mRNA] CTD PMID:20359477 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Lithocholic Acid results in decreased expression of ACADVL mRNA CTD PMID:20359477 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of ACSL1 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA]		 CTD PMID:20359477 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases abundance
increases secretion		 ISO AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Lithocholic Acid]
AHR gene mutant form results in decreased abundance of Lithocholic Acid
AHR gene mutant form results in increased secretion of Lithocholic Acid		 CTD PMID:29452137 PMID:32679164 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 affects binding
decreases activity		 ISO AKR1C1 protein binds to Lithocholic Acid
Lithocholic Acid results in decreased activity of AKR1C1 protein		 CTD PMID:8573067 PMID:12604236 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 affects binding
decreases activity		 ISO AKR1C2 protein binds to Lithocholic Acid; Lithocholic Acid binds to AKR1C2 protein
Lithocholic Acid results in decreased activity of AKR1C2 protein		 CTD PMID:8486699 PMID:8573067 PMID:12604236 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Lithocholic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin affects binding ISO Lithocholic Acid analog binds to ALB protein CTD PMID:19900495 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Lithocholic Acid co-treated with lysophosphatidic acid] results in increased activity of ALPL protein; EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein] CTD PMID:19646460 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Anxa1 annexin A1 increases expression ISO Lithocholic Acid results in increased expression of ANXA1 mRNA CTD PMID:20359477 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 multiple interactions
increases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA2 mRNA] CTD PMID:20359477 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa3 annexin A3 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of ANXA3 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA]		 CTD PMID:20359477 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Anxa4 annexin A4 multiple interactions
increases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA] CTD PMID:20359477 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Anxa5 annexin A5 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of ANXA5 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA5 mRNA]		 CTD PMID:20359477 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Apoa4 apolipoprotein A4 increases expression ISO Lithocholic Acid results in increased expression of APOA4 mRNA CTD PMID:20359477 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoc1 apolipoprotein C1 decreases expression ISO Lithocholic Acid results in decreased expression of APOC1 mRNA CTD PMID:20359477 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Apoc2 apolipoprotein C2 increases expression ISO Lithocholic Acid results in increased expression of APOC2 mRNA CTD PMID:20359477 NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476 		JBrowse link
G Apoc4 apolipoprotein C4 decreases expression ISO Lithocholic Acid results in decreased expression of APOC4 mRNA CTD PMID:20359477 NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981 		JBrowse link
G Ar androgen receptor multiple interactions
affects binding		 ISO Lithocholic Acid inhibits the reaction [Dihydrotestosterone binds to AR protein]
Lithocholic Acid binds to AR protein		 CTD PMID:15206167 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of BAAT mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]		 CTD PMID:19196849 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAK1 protein; [Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAK1 protein; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein CTD PMID:19433268 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Lithocholic Acid results in increased expression of BAX mRNA
[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAX protein; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of BAX mRNA; [Lithocholic Acid co-treated with oltipraz] results in increased expression of BAX mRNA; [Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAX protein; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAX protein; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BAX mRNA]		 CTD PMID:17881359 PMID:19433268 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]; [Lithocholic Acid co-treated with oltipraz] results in increased expression of BCL2L1 mRNA; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA] CTD PMID:19433268 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression		 ISO Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of BGLAP mRNA]
Lithocholic Acid results in increased expression of BGLAP mRNA		 CTD PMID:20055894 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases cleavage		 ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of BID protein]
Lithocholic Acid results in increased cleavage of BID protein		 CTD PMID:19054763 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases response to substance ISO BRCA2 protein results in decreased susceptibility to Lithocholic Acid CTD PMID:20028873 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Calr calreticulin affects expression EXP Lithocholic Acid affects the expression of CALR mRNA CTD PMID:18246545 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression		 ISO [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA; HR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA]
Lithocholic Acid analog results in increased expression of CAMP mRNA; Lithocholic Acid results in increased expression of CAMP mRNA; Lithocholic Acid results in increased expression of CAMP protein		 CTD PMID:18180267 PMID:19733911 PMID:22466564 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of CASP1 mRNA; Lithocholic Acid results in increased expression of CASP1 protein
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of CASP1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of CASP1 protein]		 CTD PMID:29794447 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP2 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:19054763 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases expression		 ISO Lithocholic Acid results in increased cleavage of CASP3 protein
[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP3 protein; TNF protein promotes the reaction [Lithocholic Acid results in increased expression of CASP3 protein]
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:19054763 PMID:19433268 PMID:23627780 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; [[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:19054763 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:19054763 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Lithocholic Acid results in increased localization of [VDR protein co-treated with CAV1 protein] CTD PMID:20371703 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Lithocholic Acid results in increased expression of CCNB1 mRNA CTD PMID:19000923 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A decreases expression ISO Lithocholic Acid results in decreased expression of CCT6A protein CTD PMID:21224350 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337 		JBrowse link
G Cd14 CD14 molecule increases expression
multiple interactions		 ISO Lithocholic Acid analog results in increased expression of CD14 mRNA; Lithocholic Acid results in increased expression of CD14 mRNA
Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CD14 mRNA]		 CTD PMID:18180267 PMID:19244278 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]] CTD PMID:15489543 PMID:31472180 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cers1 ceramide synthase 1 increases expression ISO Lithocholic Acid results in increased expression of CERS1 mRNA CTD PMID:21480330 NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,104,466...19,112,519 		JBrowse link
G Cers2 ceramide synthase 2 increases expression ISO Lithocholic Acid results in increased expression of CERS2 mRNA CTD PMID:21480330 NCBI chr 2:182,890,527...182,898,805
Ensembl chr 2:182,890,493...182,933,314 		JBrowse link
G Ces1d carboxylesterase 1D decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of CES1D mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CES1D mRNA]		 CTD PMID:20359477 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cfl1 cofilin 1 increases expression ISO Lithocholic Acid results in increased expression of CFL1 protein CTD PMID:21224350 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Chka choline kinase alpha increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of CHKA mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Chpt1 choline phosphotransferase 1 multiple interactions
decreases expression		 ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of CHPT1 mRNA
Lithocholic Acid results in decreased expression of CHPT1 mRNA		 CTD PMID:20359477 PMID:21480330 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Cldn1 claudin 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]] CTD PMID:31472180 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Lithocholic Acid results in increased expression of COL1A1 mRNA CTD PMID:16436656 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Lithocholic Acid results in decreased expression of CPT2 mRNA CTD PMID:20359477 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA] CTD PMID:18648741 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crot carnitine O-octanoyltransferase multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CROT mRNA] CTD PMID:20359477 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Lithocholic Acid binds to VDR protein] which results in decreased activity of CTNNB1 mRNA CTD PMID:20043299 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Lithocholic Acid results in increased expression of CXCL2 mRNA CTD PMID:24742700 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Lithocholic Acid results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
multiple interactions		 ISO
EXP		 Lithocholic Acid results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Lithocholic Acid
[CYP1A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog		 CTD PMID:18039809 PMID:18420780 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Lithocholic Acid results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO
EXP		 [Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]
Lithocholic Acid analog results in increased expression of CYP24A1 mRNA; Lithocholic Acid results in increased expression of CYP24A1 mRNA
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Vitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]		 CTD PMID:15489543 PMID:17535892 PMID:18180267 PMID:19244278 PMID:20055894 More... NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of CYP26A1 mRNA
Lithocholic Acid promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA]		 CTD PMID:18059332 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA] CTD PMID:19196849 PMID:20359477 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 decreases activity EXP Lithocholic Acid results in decreased activity of CYP2A1 protein CTD PMID:8889968 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity ISO Lithocholic Acid results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
increases expression
multiple interactions		 ISO Lithocholic Acid results in decreased activity of CYP2B10 protein
Lithocholic Acid results in increased expression of CYP2B10 mRNA
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]		 CTD PMID:15358766 PMID:18420780 PMID:19433268 PMID:20359477 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases metabolic processing
decreases activity
multiple interactions		 EXP CYP2C11 protein results in increased metabolism of Lithocholic Acid
Lithocholic Acid results in decreased activity of CYP2C11 protein
[CYP2C11 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid		 CTD PMID:8889968 PMID:18039809 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 increases expression EXP Lithocholic Acid results in increased expression of CYP2C22 mRNA CTD PMID:21311750 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
decreases activity
multiple interactions		 EXP
ISO		 CYP2C6 protein results in increased metabolism of Lithocholic Acid
Lithocholic Acid results in decreased activity of CYP2C29 protein
[CYP2C6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog		 CTD PMID:18039809 PMID:18420780 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 multiple interactions
increases metabolic processing		 EXP [CYP2D1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog CTD PMID:18039809 NCBI chr 7:113,908,950...113,913,420
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
multiple interactions		 EXP
ISO		 CYP2D6 protein results in increased metabolism of Lithocholic Acid
Lithocholic Acid results in decreased activity of CYP2D22 protein
[CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid		 CTD PMID:18039809 PMID:18420780 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Lithocholic Acid results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; [Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA] CTD PMID:19196849 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
increases hydroxylation
increases activity
increases oxidation
multiple interactions
increases metabolic processing
affects metabolic processing
decreases activity		 EXP
ISO		 Lithocholic Acid results in increased expression of CYP3A2 mRNA
CYP3A4 protein results in increased hydroxylation of Lithocholic Acid
Lithocholic Acid results in increased activity of CYP3A4 protein mutant form
CYP3A4 protein results in increased oxidation of Lithocholic Acid
[CYP3A4 protein results in increased hydroxylation of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of 3-ketocholanoic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid; [CYP3A4 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Lithocholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA]
CYP3A4 protein affects the metabolism of Lithocholic Acid
Lithocholic Acid results in decreased activity of CYP3A2 protein
CYP3A2 protein results in increased metabolism of Lithocholic Acid
[CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid; [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog; [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] affects the abundance of Lithocholic Acid		 CTD PMID:8889968 PMID:15489543 PMID:15578590 PMID:15708356 PMID:17965521 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
increases metabolic processing		 EXP [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] affects the abundance of Lithocholic Acid; [CYP3A23-3A1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid; [CYP3A23-3A1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog; [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A23-3A1 mRNA; Chenodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:18039809 PMID:20006981 PMID:20888898 PMID:21311750 PMID:34461081 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression
increases oxidation
multiple interactions		 EXP
ISO		 Lithocholic Acid results in increased expression of CYP3A9 mRNA
CYP3A5 protein results in increased oxidation of Lithocholic Acid
[CYP3A5 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; CYP3A5 gene polymorphism affects the reaction [CYP3A5 gene results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; plastochromanol 8 inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]		 CTD PMID:20888898 PMID:31102695 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of CYP4F14 mRNA
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP4F14 mRNA]		 CTD PMID:20359477 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO Lithocholic Acid results in decreased expression of CYP51 mRNA CTD PMID:20359477 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
decreases activity		 EXP
ISO		 Lithocholic Acid results in decreased expression of CYP7A1 mRNA
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]
Lithocholic Acid results in decreased activity of CYP7A1 protein		 CTD PMID:1175606 PMID:16436656 PMID:17963371 PMID:19196849 PMID:20359477 More... NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of CYP7B1 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]		 CTD PMID:19196849 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions
decreases expression		 ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA] CTD PMID:16436656 PMID:19196849 PMID:20359477 PMID:25582706 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 increases expression ISO Lithocholic Acid results in increased expression of DEGS1 mRNA CTD PMID:21480330 NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases oxidation ISO DHRS11 protein results in increased oxidation of Lithocholic Acid CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression
multiple interactions
increases activity		 ISO Lithocholic Acid results in increased expression of DIO2 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein]		 CTD PMID:19036883 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity ISO Lithocholic Acid results in increased activity of DIO3 protein CTD PMID:19036883 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO Lithocholic Acid results in increased expression of DMP1 mRNA CTD PMID:19000923 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323 		JBrowse link
G Efna1 ephrin A1 multiple interactions ISO Lithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]; Lithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]; Lithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]; Lithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein] CTD PMID:21479221 PMID:22529030 PMID:23489211 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Efnb2 ephrin B2 multiple interactions ISO Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein] CTD PMID:21479221 NCBI chr16:80,783,389...80,827,420
Ensembl chr16:80,783,417...80,824,391 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein]; EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein] CTD PMID:19646460 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Epha2 Eph receptor A2 multiple interactions
increases expression		 ISO Lithocholic Acid analog binds to and results in decreased phosphorylation of and results in decreased activity of EPHA2 protein; Lithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]; Lithocholic Acid binds to and results in decreased activity of EPHA2 protein; Lithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]; Lithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]; Lithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein]
Lithocholic Acid results in increased expression of EPHA2 protein
Lithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein]		 CTD PMID:21479221 PMID:22529030 PMID:22845314 PMID:23489211 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Ephb4 EPH receptor B4 multiple interactions ISO Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein] CTD PMID:21479221 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of EPHX1 mRNA CTD PMID:20359477 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Lithocholic Acid results in increased expression of FABP6 mRNA CTD PMID:15821044 PMID:25582706 NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Lithocholic Acid results in decreased expression of FADS1 mRNA CTD PMID:20359477 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression ISO Lithocholic Acid results in decreased expression of FADS2 mRNA CTD PMID:20359477 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789 		JBrowse link
G Fads6 fatty acid desaturase 6 decreases expression ISO Lithocholic Acid results in decreased expression of FADS6 mRNA CTD PMID:20359477 NCBI chr10:100,522,981...100,538,181
Ensembl chr10:100,522,981...100,538,181 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; [[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein; [Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased activity of FAS protein; [Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein; Lithocholic Acid results in increased localization of and results in increased activity of FAS protein CTD PMID:19054763 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of FASN mRNA] CTD PMID:20359477 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgb fibrinogen beta chain multiple interactions EXP [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA CTD PMID:21311750 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions
increases expression		 ISO [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA]
Lithocholic Acid results in increased expression of FGF15 mRNA		 CTD PMID:17696253 PMID:22561792 PMID:25055961 PMID:25582706 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA CTD PMID:17724089 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gcg glucagon multiple interactions
increases secretion		 ISO GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein] CTD PMID:23341498 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
decreases expression
multiple interactions
affects expression		 ISO Lithocholic Acid results in increased expression of GCLC mRNA; Lithocholic Acid results in increased expression of GCLC protein
Lithocholic Acid results in decreased expression of GCLC mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]
Lithocholic Acid affects the expression of GCLC mRNA; Lithocholic Acid affects the expression of GCLC protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of GCLC mRNA]		 CTD PMID:17724089 PMID:20146260 PMID:20977460 PMID:29794447 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit affects expression
decreases expression
multiple interactions
increases expression		 ISO Lithocholic Acid affects the expression of GCLM mRNA; Lithocholic Acid affects the expression of GCLM protein
Lithocholic Acid results in decreased expression of GCLM mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of GCLM mRNA]
Lithocholic Acid results in increased expression of GCLM protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]		 CTD PMID:17724089 PMID:20146260 PMID:29794447 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gnat3 G protein subunit alpha transducin 3 multiple interactions ISO GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein] CTD PMID:23341498 NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of GOT1 protein
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GOT1 protein]		 CTD PMID:38104874 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 affects binding
increases expression
multiple interactions
increases response to substance		 ISO Lithocholic Acid binds to GPBAR1 protein
Lithocholic Acid results in increased expression of GPBAR1 mRNA
[Lithocholic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Lithocholic Acid analog binds to and results in increased activity of GPBAR1 protein; Lithocholic Acid binds to and results in increased activity of GPBAR1 protein
GPBAR1 protein results in increased susceptibility to Lithocholic Acid		 CTD PMID:17963371 PMID:18180267 PMID:20023205 PMID:21454404 PMID:23041323 More... NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of GPT protein
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]
cryptotanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]; dihydrotanshinone I inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]; tanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]		 CTD PMID:24742700 PMID:36804361 PMID:38104874 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Lithocholic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gss glutathione synthetase affects expression
multiple interactions		 ISO Lithocholic Acid affects the expression of GSS mRNA; Lithocholic Acid affects the expression of GSS protein
S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]		 CTD PMID:20146260 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO
EXP		 Lithocholic Acid binds to and results in decreased activity of GSTA1 protein
Lithocholic Acid binds to [GSTA1 protein co-treated with GSTA1 protein]; Lithocholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]		 CTD PMID:3783048 PMID:12206662 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Lithocholic Acid results in increased expression of GSTA2 mRNA CTD PMID:21311750 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP Lithocholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein] CTD PMID:3783048 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
increases expression		 EXP Lithocholic Acid binds to and results in decreased activity of GSTA4 protein
Lithocholic Acid results in increased expression of GSTA4 mRNA		 CTD PMID:3954743 PMID:21311750 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression
multiple interactions		 ISO
EXP		 Lithocholic Acid results in increased expression of GSTM1 mRNA
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA]
Lithocholic Acid binds to and results in decreased activity of GSTM1 protein		 CTD PMID:3954743 PMID:20977460 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression		 EXP Lithocholic Acid binds to and results in decreased activity of GSTM2 protein
Lithocholic Acid results in increased expression of GSTM2 mRNA		 CTD PMID:3954743 PMID:21311750 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of HIF1A mRNA; Lithocholic Acid results in increased expression of HIF1A protein
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A protein]		 CTD PMID:38104874 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA CTD PMID:20359477 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA] CTD PMID:20359477 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
increases expression		 ISO NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of HMOX1 mRNA]
Lithocholic Acid results in increased expression of HMOX1 mRNA; Lithocholic Acid results in increased expression of HMOX1 protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]		 CTD PMID:17724089 PMID:20977460 PMID:24742700 PMID:29794447 PMID:31472180 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A decreases expression EXP Lithocholic Acid results in decreased expression of HNF1A mRNA CTD PMID:20888898 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression
multiple interactions		 EXP
ISO		 Lithocholic Acid results in decreased expression of HNF4A mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of HNF4A mRNA		 CTD PMID:20359477 PMID:20888898 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor multiple interactions ISO HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to HR protein]; trichostatin A inhibits the reaction [HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]] CTD PMID:22466564 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases phosphorylation ISO Lithocholic Acid results in increased phosphorylation of HSPB1 protein CTD PMID:21224350 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Lithocholic Acid results in increased expression of ICAM1 mRNA; Lithocholic Acid results in increased expression of ICAM1 protein CTD PMID:16582018 PMID:24742700 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression ISO Lithocholic Acid results in decreased expression of IDH1 mRNA CTD PMID:20359477 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Il10 interleukin 10 increases expression
decreases abundance		 ISO Lithocholic Acid results in increased expression of IL10 mRNA
IL10 gene mutant form results in decreased abundance of Lithocholic Acid		 CTD PMID:24742700 PMID:27580383 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]
Lithocholic Acid results in increased expression of and results in increased secretion of IL1B protein; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased secretion of IL1B protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA]		 CTD PMID:18515093 PMID:24742700 PMID:29794447 PMID:38104874 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of IL6 mRNA; Lithocholic Acid results in increased expression of IL6 protein
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein]
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein]		 CTD PMID:24742700 PMID:29794447 PMID:38104874 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Lithocholic Acid co-treated with Glucose] results in increased secretion of INS protein CTD PMID:23022524 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Lithocholic Acid analog results in increased expression of ITGAM mRNA CTD PMID:18180267 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases metabolic processing ISO Lithocholic Acid results in decreased metabolism of ITGB1 protein CTD PMID:21224350 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Lithocholic Acid results in increased expression of JUN mRNA CTD PMID:19000923 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Lithocholic Acid results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions
increases response to substance		 ISO
EXP		 [KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid
KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid; KCNMA1 protein results in increased susceptibility to Lithocholic Acid
Lithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]		 CTD PMID:18242174 PMID:18650555 PMID:22123969 PMID:28090300 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions
increases response to substance
affects binding
increases activity		 ISO
EXP		 [KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
KCNMB1 protein results in increased susceptibility to Lithocholic Acid
Lithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]
Lithocholic Acid binds to KCNMB1 protein
Lithocholic Acid analog results in increased activity of KCNMB1 protein; Lithocholic Acid results in increased activity of KCNMB1 protein		 CTD PMID:17468198 PMID:18650555 PMID:19852931 PMID:22123969 PMID:22945504 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798 		JBrowse link
G Klk6 kallikrein related-peptidase 6 multiple interactions EXP [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA CTD PMID:21311750 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121 		JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of LCAT mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LCAT mRNA		 CTD PMID:20359477 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO Lithocholic Acid results in decreased expression of LDLR mRNA CTD PMID:20359477 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lpcat1 lysophosphatidylcholine acyltransferase 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of LPCAT1 mRNA
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr 1:29,766,070...29,816,401
Ensembl chr 1:29,766,071...29,816,401 		JBrowse link
G Lpcat2 lysophosphatidylcholine acyltransferase 2 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of LPCAT2 mRNA
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr19:14,088,389...14,152,742
Ensembl chr19:14,089,686...14,152,829 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 decreases expression ISO Lithocholic Acid results in decreased expression of LPCAT3 mRNA CTD PMID:21480330 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880 		JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of LPCAT4 mRNA
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO Lithocholic Acid results in increased expression of LPL mRNA CTD PMID:20359477 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrp2 LDL receptor related protein 2 decreases expression ISO Lithocholic Acid results in decreased expression of LRP2 protein CTD PMID:15375181 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Lypla1 lysophospholipase 1 multiple interactions
decreases expression		 ISO [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LYPLA1 mRNA
Lithocholic Acid results in decreased expression of LYPLA1 mRNA		 CTD PMID:20359477 PMID:21480330 NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746 		JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO Lithocholic Acid results in increased expression of and results in increased activity of MAF protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein] CTD PMID:20146260 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Mafg MAF bZIP transcription factor G multiple interactions ISO Lithocholic Acid results in increased expression of and results in increased activity of MAFG protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein] CTD PMID:20146260 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases activity		 ISO [Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA; MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases activity		 ISO [Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA CTD PMID:19782465 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member affects localization
multiple interactions
increases expression		 ISO Lithocholic Acid affects the localization of MCL1 protein
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]; [Lithocholic Acid co-treated with oltipraz] results in increased expression of MCL1 mRNA; Phenobarbital inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of MCL1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]		 CTD PMID:19433268 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
increases expression		 ISO Lithocholic Acid results in decreased expression of MMP2 protein
Lithocholic Acid results in increased expression of MMP2 mRNA		 CTD PMID:16436656 PMID:21224350 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Lithocholic Acid results in decreased expression of MMP9 protein CTD PMID:21224350 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mras muscle RAS oncogene homolog affects binding EXP Lithocholic Acid binds to MRAS protein CTD PMID:18641422 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408 		JBrowse link
G Mt1 metallothionein 1 increases expression EXP Lithocholic Acid results in increased expression of MT1A mRNA CTD PMID:21311750 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A increases expression EXP Lithocholic Acid results in increased expression of MT2A mRNA CTD PMID:21311750 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]
Lithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein]		 CTD PMID:15489543 PMID:21917910 PMID:22466564 PMID:23015691 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR1 protein] CTD PMID:22466564 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein] CTD PMID:21917910 PMID:22466564 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
decreases response to substance		 ISO [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA; Lithocholic Acid results in increased localization of and results in increased activity of NFE2L2 protein; NFE2L2 protein inhibits the reaction [Lithocholic Acid results in increased expression of GSTA4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]
Lithocholic Acid results in decreased expression of NFE2L2 mRNA; Lithocholic Acid results in decreased expression of NFE2L2 protein
NFE2L2 protein results in decreased susceptibility to Lithocholic Acid
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid results in decreased expression of and results in decreased activity of NFE2L2 protein; Lithocholic Acid results in increased expression of and results in increased localization of and results in increased activity of NFE2L2 protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]		 CTD PMID:17724089 PMID:20146260 PMID:20977460 PMID:29794447 PMID:31472180 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Lithocholic Acid inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] CTD PMID:18515093 PMID:31472180 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression		 ISO Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 protein]
Lithocholic Acid results in increased expression of NLRP3 mRNA; Lithocholic Acid results in increased expression of NLRP3 protein		 CTD PMID:29794447 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
decreases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of NQO1 mRNA
Lithocholic Acid results in decreased expression of NQO1 mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NQO1 mRNA]		 CTD PMID:17724089 PMID:20977460 PMID:29794447 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Lithocholic Acid results in increased expression of NR0B2 mRNA
Lithocholic Acid results in increased expression of NR0B2 mRNA; Lithocholic Acid results in increased expression of NR0B2 protein
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA
[Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA
Lithocholic Acid results in decreased expression of NR0B2 mRNA
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNA		 CTD PMID:17963371 PMID:19562681 PMID:20359477 PMID:20888898 PMID:22540009 More... NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression
decreases response to substance
multiple interactions		 EXP
ISO		 Lithocholic Acid results in decreased expression of NR1H3 mRNA
NR1H3 protein results in decreased susceptibility to Lithocholic Acid
Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA]; Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA]; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA]; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]		 CTD PMID:17256725 PMID:20359477 PMID:20888898 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
increases activity
increases response to substance
decreases expression		 EXP
ISO		 [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of UGT2B15 mRNA; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; NR1H4 protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA]
[Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein; Lithocholic Acid binds to and results in decreased activity of NR1H4 protein; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; Lithocholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]
Lithocholic Acid results in increased expression of NR1H4 mRNA
NR1H4 protein results in increased susceptibility to Lithocholic Acid; NR1H4 results in increased susceptibility to Lithocholic Acid
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]
Lithocholic Acid results in decreased expression of NR1H4 mRNA		 CTD PMID:12875239 PMID:14684751 PMID:15489543 PMID:15821044 PMID:17963371 More... NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases response to substance
increases response to substance
decreases expression
multiple interactions
increases localization
increases activity		 ISO
EXP		 NR1I2 protein results in decreased susceptibility to Lithocholic Acid
NR1I2 results in increased susceptibility to Lithocholic Acid
Lithocholic Acid results in decreased expression of NR1I2 mRNA; Lithocholic Acid results in decreased expression of NR1I2 protein
[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A23-3A1 mRNA; [NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]; Lithocholic Acid binds to and results in increased activity of NR1I2 protein
Lithocholic Acid results in increased localization of NR1I2 protein
[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1I2 protein; Lithocholic Acid binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA]		 CTD PMID:12370413 PMID:14570758 PMID:15358766 PMID:15883047 PMID:16054614 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
decreases response to substance
decreases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of NR1I3 mRNA
NR1I3 protein results in decreased susceptibility to Lithocholic Acid
Lithocholic Acid results in decreased expression of NR1I3 mRNA
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in decreased susceptibility to Lithocholic Acid; [Phenobarbital results in increased activity of NR1I3 protein] which results in decreased susceptibility to Lithocholic Acid; Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein; Lithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in increased abundance of Bile Acids and Salts]]; oltipraz inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; Phenobarbital promotes the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]		 CTD PMID:14742670 PMID:15358766 PMID:16929008 PMID:19196849 PMID:19433268 More... NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 decreases expression EXP Lithocholic Acid results in decreased expression of NR5A2 mRNA CTD PMID:20888898 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Ocln occludin multiple interactions ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]] CTD PMID:31472180 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Lithocholic Acid results in increased expression of ORM1 mRNA CTD PMID:19000923 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity		 ISO 3-aminobenzamide inhibits the reaction [Lithocholic Acid analog results in increased activity of PARP1 protein] CTD PMID:2120135 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Lithocholic Acid results in decreased expression of PCTP mRNA CTD PMID:20359477 NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867 		JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1B, choline increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of PCYT1B mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr  X:58,378,090...58,471,623
Ensembl chr  X:58,378,116...58,468,935 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Lithocholic Acid results in increased expression of PGK1 protein CTD PMID:21224350 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Lithocholic Acid results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
increases expression		 ISO [Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA; [Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA; MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA]; MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] CTD PMID:19782465 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595 		JBrowse link
G Pld1 phospholipase D1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of PLD1 mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of PLD2 mRNA
SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA]		 CTD PMID:21480330 PMID:23034213 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Plpp1 phospholipid phosphatase 1 increases expression ISO Lithocholic Acid results in increased expression of PLPP1 mRNA CTD PMID:20359477 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268 		JBrowse link
G Plpp2 phospholipid phosphatase 2 increases expression ISO Lithocholic Acid results in increased expression of PLPP2 mRNA CTD PMID:20359477 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071 		JBrowse link
G Plscr1 phospholipid scramblase 1 multiple interactions
increases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of PLSCR1 mRNA] CTD PMID:20359477 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692 		JBrowse link
G Polb DNA polymerase beta multiple interactions EXP Lithocholic Acid analog binds to and results in decreased activity of POLB protein; Lithocholic Acid binds to and results in decreased activity of POLB protein; Lithocholic Acid binds to and results in decreased activity of POLB protein mutant form CTD PMID:15311928 PMID:15656580 PMID:16996474 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of Lithocholic Acid CTD PMID:25034404 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO Lithocholic Acid results in decreased expression of PPARA mRNA
[PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of PPARA mRNA		 CTD PMID:18648741 PMID:20359477 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkcb protein kinase C, beta increases activity ISO Lithocholic Acid results in increased activity of PRKCB protein CTD PMID:7705931 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression
affects expression		 EXP Lithocholic Acid results in decreased expression of PSMB4 mRNA
Lithocholic Acid affects the expression of PSMB4 mRNA		 CTD PMID:18246545 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO [PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]; [SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA CTD PMID:18648741 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO Lithocholic Acid results in decreased phosphorylation of and results in decreased activity of PTK2 protein CTD PMID:21224350 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin multiple interactions ISO Lithocholic Acid results in decreased phosphorylation of and results in decreased activity of PXN protein CTD PMID:21224350 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression		 ISO Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of PYCARD mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of PYCARD protein]
Lithocholic Acid results in increased expression of PYCARD mRNA; Lithocholic Acid results in increased expression of PYCARD protein		 CTD PMID:29794447 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rab12 RAB12, member RAS oncogene family affects binding EXP Lithocholic Acid binds to RAB12 protein CTD PMID:18641422 NCBI chr 9:106,480,301...106,506,895
Ensembl chr 9:106,480,301...106,506,910 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family affects binding EXP Lithocholic Acid binds to RAB3A protein CTD PMID:18641422 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Rab3d RAB3D, member RAS oncogene family affects binding EXP Lithocholic Acid binds to RAB3D protein CTD PMID:18641422 NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases phosphorylation ISO Lithocholic Acid results in increased phosphorylation of RANGAP1 protein CTD PMID:21224350 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Lithocholic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]] CTD PMID:18515093 PMID:31472180 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnh1 ribonuclease/angiogenin inhibitor 1 increases expression ISO Lithocholic Acid results in increased expression of RNH1 protein CTD PMID:21224350 NCBI chr 1:196,269,293...196,281,763
Ensembl chr 1:196,269,293...196,281,910 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO
EXP		 Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]
[NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]		 CTD PMID:12370413 PMID:15578590 PMID:15824121 PMID:20153625 PMID:21917910 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO Lithocholic Acid binds to RXRB protein CTD PMID:11939783 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G S100g S100 calcium binding protein G increases expression ISO
EXP		 Lithocholic Acid results in increased expression of S100G mRNA CTD PMID:15824121 PMID:17535892 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
increases expression		 ISO Lithocholic Acid results in decreased expression of SCARB1 mRNA; Lithocholic Acid results in decreased expression of SCARB1 protein
Lithocholic Acid results in increased expression of SCARB1 mRNA		 CTD PMID:15883047 PMID:19000923 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SCD1 mRNA] CTD PMID:20359477 PMID:21480330 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sgms1 sphingomyelin synthase 1 increases expression ISO Lithocholic Acid results in increased expression of SGMS1 mRNA CTD PMID:21480330 NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]] CTD PMID:31472180 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
decreases expression		 ISO [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of SLC10A1 mRNA; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]
Lithocholic Acid results in decreased expression of SLC10A1 mRNA; Lithocholic Acid results in decreased expression of SLC10A1 protein		 CTD PMID:12637555 PMID:16436656 PMID:17256725 PMID:18032408 PMID:20977460 More... NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions
increases expression		 ISO NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA] CTD PMID:17256725 PMID:25582706 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Lithocholic Acid results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc51a solute carrier family 51 member A multiple interactions
increases expression		 EXP
ISO		 [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51A mRNA
Lithocholic Acid results in increased expression of SLC51A mRNA
Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA]		 CTD PMID:17256725 PMID:19562681 PMID:25055961 PMID:25582706 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485 		JBrowse link
G Slc51b SLC51 subunit beta multiple interactions
increases expression		 ISO
EXP		 NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]
[Lithocholic Acid binds to VDR protein] which affects the expression of SLC51B mRNA		 CTD PMID:17256725 PMID:19562681 PMID:23034213 PMID:25055961 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Lithocholic Acid results in increased expression of SLCO1A4 mRNA CTD PMID:23034213 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
increases transport
increases expression
increases uptake
multiple interactions		 ISO Lithocholic Acid results in decreased expression of SLCO1B2 mRNA
SLCO1B3 protein results in increased transport of Lithocholic Acid
Lithocholic Acid results in increased expression of SLCO1B3 mRNA
SLCO1B3 protein results in increased uptake of Lithocholic Acid
[SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA
Lithocholic Acid results in increased expression of SLCO1B2 mRNA
Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA]		 CTD PMID:12637555 PMID:16534140 PMID:17256725 PMID:18648741 PMID:25055961 More... NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
increases response to substance		 ISO SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]
SMAD3 protein results in increased susceptibility to Lithocholic Acid		 CTD PMID:23034213 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 increases expression ISO Lithocholic Acid results in increased expression of SMPD3 mRNA CTD PMID:21480330 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Lithocholic Acid results in increased expression of SOD1 mRNA CTD PMID:21311750 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sptlc1 serine palmitoyltransferase, long chain base subunit 1 increases expression ISO Lithocholic Acid results in increased expression of SPTLC1 mRNA CTD PMID:21480330 NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295 		JBrowse link
G Sptlc2 serine palmitoyltransferase, long chain base subunit 2 increases expression ISO Lithocholic Acid results in increased expression of SPTLC2 mRNA CTD PMID:21480330 NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 ISO Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SREBF1 mRNA] CTD PMID:20359477 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G St3gal1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 multiple interactions ISO Lithocholic Acid analog results in decreased expression of and results in decreased activity of ST3GAL1 protein CTD PMID:21224350 NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236 		JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 decreases activity ISO Lithocholic Acid analog results in decreased activity of ST3GAL3 protein CTD PMID:21224350 NCBI chr 5:131,470,348...131,670,794
Ensembl chr 5:131,470,348...131,670,810 		JBrowse link
G St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 increases phosphorylation ISO Lithocholic Acid results in increased phosphorylation of ST3GAL4 protein CTD PMID:21224350 NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389 		JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 decreases activity ISO Lithocholic Acid analog results in decreased activity of ST6GAL1 protein CTD PMID:21224350 NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased phosphorylation of STAT3 mRNA]; Lithocholic Acid results in increased expression of and results in increased phosphorylation of STAT3 mRNA CTD PMID:38104874 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stim1 stromal interaction molecule 1 affects localization EXP Lithocholic Acid affects the localization of STIM1 protein CTD PMID:18342630 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Lithocholic Acid results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation
multiple interactions
increases expression		 ISO
EXP		 SULT2A1 protein results in increased sulfation of Lithocholic Acid
[Cyclosporine results in decreased activity of SULT2A1 protein] which results in increased abundance of Lithocholic Acid
[NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]		 CTD PMID:12370413 PMID:20102295 PMID:21839837 PMID:26198044 PMID:36473578 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Lithocholic Acid results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of TGFB1 mRNA
EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein]
NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA]		 CTD PMID:19646460 PMID:21480330 PMID:23034213 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO Lithocholic Acid results in increased expression of TGFBR1 mRNA CTD PMID:23034213 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression ISO Lithocholic Acid results in increased expression of TGFBR2 mRNA CTD PMID:23034213 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Lithocholic Acid results in increased expression of TIMP1 mRNA CTD PMID:16436656 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]] CTD PMID:31472180 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]]; Lithocholic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; TNF protein promotes the reaction [Lithocholic Acid results in increased expression of CASP3 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein]
Lithocholic Acid results in increased expression of TNF mRNA; Lithocholic Acid results in increased expression of TNF protein		 CTD PMID:18515093 PMID:21480330 PMID:23566200 PMID:23627780 PMID:29794447 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of TNFSF11 mRNA] CTD PMID:20055894 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Trap1 TNF receptor-associated protein 1 decreases expression ISO Lithocholic Acid results in decreased expression of TRAP1 protein CTD PMID:21224350 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 multiple interactions
increases expression		 ISO
EXP		 [Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA
Lithocholic Acid results in increased expression of TRPV6 mRNA		 CTD PMID:15489543 PMID:17535892 PMID:18180267 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression		 ISO [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA
Lithocholic Acid results in increased expression of TXN protein		 CTD PMID:17724089 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of TXNRD1 mRNA; Lithocholic Acid results in increased expression of TXNRD1 protein
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]		 CTD PMID:17724089 PMID:20977460 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
decreases expression		 ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA] CTD PMID:19196849 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions		 ISO Lithocholic Acid results in increased expression of UGT1A3 mRNA
[Uridine Diphosphate Glucuronic Acid co-treated with UGT1A3 protein] results in increased metabolism of Lithocholic Acid		 CTD PMID:20189675 PMID:36473578 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases glucuronidation EXP UGT2B protein results in increased glucuronidation of Lithocholic Acid CTD PMID:2429951 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Lithocholic Acid results in increased expression of UGT2B17 mRNA CTD PMID:21311750 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 multiple interactions EXP [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of UGT2B15 mRNA CTD PMID:21311750 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter] CTD PMID:15821044 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Lithocholic Acid results in increased expression of VCAM1 mRNA; Lithocholic Acid results in increased expression of VCAM1 protein CTD PMID:16582018 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor multiple interactions
affects binding
increases phosphorylation
increases activity
increases expression
decreases expression		 ISO
EXP		 Lithocholic Acid binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein mutant form; Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 protein]
Lithocholic Acid analog binds to VDR protein; Lithocholic Acid binds to VDR protein; Lithocholic Acid binds to VDR protein mutant form
Lithocholic Acid results in increased phosphorylation of VDR protein
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA; [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51A mRNA; [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51B mRNA; [Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA; Lithocholic Acid binds to and results in increased activity of VDR protein
Lithocholic Acid metabolite results in increased activity of VDR protein; Lithocholic Acid results in increased activity of VDR protein
[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to VDR protein] which results in decreased activity of CTNNB1 mRNA; HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]; Lithocholic Acid analog binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of and results in increased localization of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein mutant form; Lithocholic Acid inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR1 protein]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]; Lithocholic Acid promotes the reaction [VDR protein binds to HR protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]; Lithocholic Acid results in increased expression of and results in increased activity of VDR protein; Lithocholic Acid results in increased localization of [VDR protein co-treated with CAV1 protein]; trichostatin A inhibits the reaction [HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of ABCB1 mRNA]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA]
Lithocholic Acid results in increased expression of VDR mRNA; Lithocholic Acid results in increased expression of VDR protein
Lithocholic Acid results in decreased expression of VDR mRNA		 CTD PMID:14525957 PMID:15489543 PMID:15578590 PMID:15824121 PMID:17963371 More... NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Lithocholic Acid results in increased expression of VEGFA mRNA CTD PMID:19000923 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Wdr1 WD repeat domain 1 decreases expression ISO Lithocholic Acid results in decreased expression of WDR1 protein CTD PMID:21224350 NCBI chr14:72,258,032...72,291,768
Ensembl chr14:72,257,956...72,291,766 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 increases expression ISO Lithocholic Acid results in increased expression of ZEB2 mRNA CTD PMID:19000923 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
7-oxolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases reduction
multiple interactions		 ISO HSD11B1 protein results in increased reduction of 7-ketolithocholic acid
[HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid; [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid		 CTD PMID:21453287 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
glycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation		 ISO [CYP3A4 protein results in increased hydroxylation of glycolithocholic acid] which results in increased abundance of glycohyodeoxycholic acid CTD PMID:36473578 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases abundance ISO HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid CTD PMID:25061560 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of glycolithocholic acid CTD PMID:25034404 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of glycolithocholic acid CTD PMID:36473578 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
lithocholic acid sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO sulfolithocholic acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTA4 protein CTD PMID:3954743 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTM1 protein CTD PMID:3954743 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP sulfolithocholic acid binds to and results in decreased activity of GSTM2 protein CTD PMID:3954743 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
sulfoglycolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc10a1 solute carrier family 10 member 1 increases uptake ISO SLC10A1 protein results in increased uptake of sulfolithocholylglycine CTD PMID:29024779 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
taurolithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 affects localization
multiple interactions
decreases activity		 EXP
ISO		 Taurolithocholic Acid affects the localization of ABCB11 protein
Taurolithocholic Acid affects the localization of and affects the activity of ABCB11 protein
Taurolithocholic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Taurolithocholic Acid results in decreased activity of ABCB11 protein		 CTD PMID:12865277 PMID:15763547 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects localization
multiple interactions		 EXP Taurolithocholic Acid affects the localization of ABCC2 protein
3-chloroacetylindole inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; [Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; CYM-5520 inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]		 CTD PMID:31300867 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions		 EXP Taurolithocholic Acid results in increased phosphorylation of AKT1 protein
JTE 013 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]		 CTD PMID:31300867 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions
affects binding		 ISO [Taurolithocholic Acid binds to and affects the activity of CHRM3 protein] which results in increased abundance of Inositol Phosphates; Taurolithocholic Acid binds to and affects the activity of CHRM3 protein
Taurolithocholic Acid binds to CHRM3 protein		 CTD PMID:12379313 PMID:12464352 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of Taurolithocholic Acid CTD PMID:36473578 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Taurolithocholic Acid results in increased expression of FOS mRNA
ursodoxicoltaurine inhibits the reaction [Taurolithocholic Acid results in increased expression of FOS mRNA]		 CTD PMID:18164257 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases abundance ISO HSD11B1 gene mutant form results in increased abundance of Taurolithocholic Acid CTD PMID:25061560 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Taurolithocholic Acid results in increased expression of JUN mRNA
ursodoxicoltaurine inhibits the reaction [Taurolithocholic Acid results in increased expression of JUN mRNA]		 CTD PMID:18164257 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of Taurolithocholic Acid CTD PMID:25034404 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases activity
multiple interactions		 EXP Taurolithocholic Acid results in increased activity of PRKACA protein
JTE 013 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]		 CTD PMID:31300867 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions EXP S1PR2 protein affects the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:31300867 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G Smad3 SMAD family member 3 increases abundance ISO SMAD3 protein results in increased abundance of Taurolithocholic Acid CTD PMID:23034213 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of Taurolithocholic Acid CTD PMID:36473578 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
taurolithocholic acid sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions
decreases response to substance		 EXP AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein]
AGT protein results in decreased susceptibility to taurolithocholic acid 3-sulfate		 CTD PMID:23300732 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 EXP AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein] CTD PMID:23300732 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO taurolithocholic acid 3-sulfate results in decreased activity of CFTR protein CTD PMID:15634668 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO taurolithocholic acid 3-sulfate binds to CHRM1 protein CTD PMID:12464352 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA] CTD PMID:22517774 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA] CTD PMID:22517774 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      application 19661
        pharmaceutical 19502
          drug 19502
            protective agent 18218
              geroprotector 17380
                lithocholic acid 267
                  7,12-dioxolithocholic acid 0
                  7-oxolithocholic acid + 1
                  glycolithocholic acid + 5
                  lithocholic acid 24-O-(beta-D-glucuronide) 0
                  lithocholic acid 3-O-(beta-D-glucuronide) 0
                  lithocholic acid sulfate 4
                  lithocholic acid-2,2,4,4-d4 0
                  lithocholyl-CoA 0
                  taurolithocholic acid + 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic polycyclic compound 17247
                                  steroid 14693
                                    steroid fundamental parent 14489
                                      cholane 1002
                                        cholanoid 1002
                                          cholanic acids 986
                                            cholanic acid 986
                                              5beta-cholanic acid 986
                                                hydroxy-5beta-cholanic acid 986
                                                  bile acid 986
                                                    lithocholic acid 267
                                                      7,12-dioxolithocholic acid 0
                                                      7-oxolithocholic acid + 1
                                                      glycolithocholic acid + 5
                                                      lithocholic acid 24-O-(beta-D-glucuronide) 0
                                                      lithocholic acid 3-O-(beta-D-glucuronide) 0
                                                      lithocholic acid sulfate 4
                                                      lithocholic acid-2,2,4,4-d4 0
                                                      lithocholyl-CoA 0
                                                      taurolithocholic acid + 19
paths to the root