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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70913
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc5
Name: ATP binding cassette subfamily C member 5
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc5increases expressionISOAbcc5 (Mus musculus)6480464CTDLithocholic Acid results in increased expression of ABCC5 mRNA; Lithocholic Acid results in increased expression of ABCC5 proteinPMID:18032408 PMID:20977460 PMID:23034213
Abcc5multiple interactionsISOAbcc5 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]PMID:18032408 PMID:20977460
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