Cers2 (ceramide synthase 2) - Rat Genome Database

Name: Cers2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Cers2 (ceramide synthase 2) Rattus norvegicus

Analyze

Symbol:

Cers2

Name:

ceramide synthase 2

RGD ID:

1310059

Description:

Predicted to enable sphingosine N-acyltransferase activity. Involved in several processes, including negative regulation of Schwann cell migration; negative regulation of Schwann cell proliferation involved in axon regeneration; and negative regulation of axon regeneration. Predicted to be located in endoplasmic reticulum. Biomarker of sciatic neuropathy. Orthologous to human CERS2 (ceramide synthase 2); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LAG1 homolog, ceramide synthase 2; Lass2; LOC310667; longevity assurance homolog 2 (S. cerevisiae); MGC124761

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CERS2 (ceramide synthase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Cers2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cers2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CERS2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CERS2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cers2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CERS2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CERS2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cers2 (ceramide synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RFXANK (regulatory factor X associated ankyrin containing protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CERS2 (ceramide synthase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cers2 (ceramide synthase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cers2a (ceramide synthase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cers2b (ceramide synthase 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LAC1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LAG1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hyl-2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	schlank	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cers2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,579,511 - 185,587,789 (+)	NCBI		GRCr8
mRatBN7.2	2	182,890,527 - 182,898,805 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,890,493 - 182,933,314 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,555,601 - 190,563,871 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,351,235 - 188,359,357 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	183,188,096 - 183,196,368 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	196,487,656 - 196,495,930 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	196,487,656 - 196,496,986 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,986,084 - 215,994,362 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	190,224,017 - 190,232,275 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	190,186,196 - 190,195,027 (+)	NCBI
Celera	2	175,424,025 - 175,432,283 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

immunodeficiency 42 (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

sciatic neuropathy (IEP)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bortezomib (ISO)

carbamazepine (ISO)

chlorpyrifos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

epoxiconazole (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

fumonisin B1 (ISO)

GW 4064 (ISO)

inulin (ISO)

ivermectin (ISO)

lithocholic acid (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenethyl caffeate (ISO)

resveratrol (ISO)

tetrachloromethane (ISO)

tetracycline (ISO)

triclocarban (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ceramide biosynthetic process (IBA,ISO)

negative regulation of axon regeneration (IMP)

negative regulation of Schwann cell migration (IMP)

negative regulation of Schwann cell proliferation (IMP)

negative regulation of Schwann cell proliferation involved in axon regeneration (IMP)

regulation of lipid metabolic process (ISO)

response to immobilization stress (IEP)

sphingolipid biosynthetic process (ISO)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

nucleus (IEA)

Molecular Function

DNA binding (IEA)

N-acyltransferase activity (ISO)

protein binding (ISO)

sphingosine N-acyltransferase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Enriched Environment Enhances the Myelin Regulatory Factor by mTOR Signaling and Protects the Myelin Membrane Against Oxidative Damage in Rats Exposed to Chronic Immobilization Stress.	Thamizhoviya G and Vanisree AJ, Neurochem Res. 2021 Dec;46(12):3314-3324. doi: 10.1007/s11064-021-03433-8. Epub 2021 Aug 27.
6.	miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury.	Yu B, etal., J Cell Sci. 2012 Jun 1;125(Pt 11):2675-83. doi: 10.1242/jcs.098996. Epub 2012 Mar 5.

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:12947022	PMID:15823095	PMID:17977534	PMID:18165233	PMID:19946888	PMID:23275342	PMID:26620563	PMID:29632068

Genomics

Comparative Map Data

Cers2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,579,511 - 185,587,789 (+)	NCBI		GRCr8
mRatBN7.2	2	182,890,527 - 182,898,805 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,890,493 - 182,933,314 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,555,601 - 190,563,871 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,351,235 - 188,359,357 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	183,188,096 - 183,196,368 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	196,487,656 - 196,495,930 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	196,487,656 - 196,496,986 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,986,084 - 215,994,362 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	190,224,017 - 190,232,275 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	190,186,196 - 190,195,027 (+)	NCBI
Celera	2	175,424,025 - 175,432,283 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

CERS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	150,965,186 - 150,974,835 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	150,960,583 - 150,975,003 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	150,937,662 - 150,947,311 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	149,204,273 - 149,214,064 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	124,053,344 - 124,063,135 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	122,314,777 - 122,324,583 (-)	NCBI		HuRef
CHM1_1	1	152,332,969 - 152,342,798 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	150,088,885 - 150,098,532 (-)	NCBI		T2T-CHM13v2.0

Cers2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	95,222,077 - 95,230,910 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	95,222,102 - 95,230,910 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	95,314,771 - 95,323,599 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	95,314,791 - 95,323,599 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	95,119,174 - 95,127,492 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	95,400,656 - 95,408,974 (+)	NCBI		MGSCv36	mm8
Celera	3	96,746,553 - 96,754,871 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.74	NCBI

Cers2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955588	336,083 - 342,599 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955588	338,381 - 342,139 (-)	NCBI	ChiLan1.0	ChiLan1.0

CERS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	98,858,330 - 98,868,259 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	98,612,561 - 98,622,498 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	126,314,483 - 126,324,312 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	129,962,894 - 129,973,074 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	129,962,022 - 129,972,722 (-)	Ensembl	panpan1.1		panPan2

CERS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	60,069,723 - 60,073,622 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	60,070,585 - 60,081,502 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	59,513,854 - 59,522,875 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	61,085,850 - 61,094,878 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	61,085,840 - 61,094,823 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	59,914,771 - 59,918,641 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,999,724 - 60,008,740 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	60,727,161 - 60,736,178 (-)	NCBI		UU_Cfam_GSD_1.0

Cers2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	22,162,465 - 22,170,961 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	1,192,847 - 1,201,909 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	1,192,843 - 1,201,863 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CERS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	98,250,964 - 98,260,427 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	98,250,773 - 98,260,504 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	107,504,661 - 107,514,743 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CERS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666038	12,306,730 - 12,316,398 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cers2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	18,851,612 - 18,855,255 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	18,851,681 - 18,855,267 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cers2
14 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	386
Count of miRNA genes:	189
Interacting mature miRNAs:	221
Transcripts:	ENSRNOT00000028699
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43154682	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	114837527	185876470	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	135552573	202446871	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	143657411	190602963	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168354880	185122374	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	172710921	184114403	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat

Markers in Region

AW535103

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,899,017 - 182,899,215 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,496,147 - 196,496,344	NCBI	Rnor6.0
Rnor_5.0	2	215,994,575 - 215,994,772	UniSTS	Rnor5.0
RGSC_v3.4	2	190,232,508 - 190,232,705	UniSTS	RGSC3.4
Celera	2	175,432,516 - 175,432,713	UniSTS
RH 3.4 Map	2	1195.21	UniSTS
Cytogenetic Map	2	q34	UniSTS

UniSTS:234764

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,898,559 - 182,898,730 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,495,689 - 196,495,859	NCBI	Rnor6.0
Rnor_5.0	2	215,994,117 - 215,994,287	UniSTS	Rnor5.0
RGSC_v3.4	2	190,232,050 - 190,232,220	UniSTS	RGSC3.4
Celera	2	175,432,058 - 175,432,228	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	41	57	41	19	41	2	2	74	35	36	11	2
Low		2					6	9			5		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI284504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF110567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK365108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000028699 ⟹ ENSRNOP00000028699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,890,493 - 182,933,314 (+)	Ensembl
Rnor_6.0 Ensembl	2	196,487,656 - 196,495,904 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000080324 ⟹ ENSRNOP00000073283

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,890,555 - 182,899,855 (+)	Ensembl
Rnor_6.0 Ensembl	2	196,487,684 - 196,496,986 (+)	Ensembl

RefSeq Acc Id:

NM_001033700 ⟹ NP_001028872

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,579,511 - 185,587,769 (+)	NCBI
mRatBN7.2	2	182,890,527 - 182,898,785 (+)	NCBI
Rnor_6.0	2	196,487,656 - 196,495,914 (+)	NCBI
Rnor_5.0	2	215,986,084 - 215,994,362 (+)	NCBI
RGSC_v3.4	2	190,224,017 - 190,232,275 (+)	RGD
Celera	2	175,424,025 - 175,432,283 (+)	RGD

Sequence:

show sequence

AGGACCCGGCCCAGTCAGTGCGCACTGGCCGGGCGCTAGAAGTGGGACACGGAGCAGCGGCGCC
CGGACCGGTCAGCTTTGCACTGGCCGCCGAGATGCTCCAGACCTTGTATGACTACTTCTGGTGG
GAACGACTATGGCTGCCTGTGAACTTAACCTGGGCTGATCTAGAAGACAAAGATGGACGTGTCT
ATGCCAAAGCCTCAGACCTCTACATCACACTACCCCTGGCCCTGCTCTTTCTCATCATTCGATA
CTTCTTTGAGCTTTATGTGGCTACACCCCTGGCTGCCCTCCTGAATGTTAAGGAGAAAACCCGA
CTGCGGGCACCTCCCAATGCCACCTTAGAGCATTTCTACCTGACCGTCGGCAAGCAGCCCAAGC
AGGTGGAGGTAGACCTTTTGTCTCGGCAGAGTGGGCTCTCTGGACGCCAGGTAGAACGTTGGTT
CCGCCGCCGCCGCAACCAGGACAGGCCCAGTCTTCTCAAGAAGTTCCGAGAAGCCAGCTGGAGA
TTCACATATTACCTCATTGCCTTTGTTGCTGGCATGGCTGTCACTGTGGATAAACCCTGGTTCT
ATGACTTGAGGAAAGTTTGGGAAGGATATCCCATACAGAGTATCATCCCTTCTCAGTATTGGTA
CTACATGATTGAGCTTGCTTTCTACTGGTCCCTGCTCTTCAGCATTGCCTCCGATGTCAAGCGA
AAGGATTTTAAGGAACAGATCATCCACCATGTGGCCACCATCATTCTCCTCTGCTTCTCCTGGT
TTGCCAATTATGTCCGAGCAGGGACCCTCATCATGGCTCTGCATGACTCTTCCGACTACCTGCT
GGAGTCTGCCAAGATGTTTAACTACGCAGGATGGAAAAACACCTGCAACAACCTCTTCATTGTC
TTCGCCGTCGTTTTCATCATCACTCGACTGGTTATCATGCCCTTCTGGATCCTCCACTGCACAA
TGATATACCCACTGGAGTTCTACCCTGCCTTCTTTGGCTATTACTTCTTCAATTCCATGATGGT
AGTGCTACAGATGCTCCATGTCTTCTGGGCCTACTTCATTGTGCGCATGGCCCACAAGTTCATA
ACTGGAAAGCTGGTAGAAGATGAACGCAGTGACAGAGAAGAAACAGAGAGTTCAGAGGGGGAGG
AGGCTGCAGCTGGGGCAGGAGCAAAGAGCCGACTCCTAGCTAATGGCCACCCCATCCTCAATAA
CAACCATCCTAAGAATGACTGAACCGTTGTCCTAGCTGCCTCCCACATCAATACGCGAAGCCAA
GAAACTAGCCAAGCTTCCCTGTAGGGGCATTTGAGCTCTGGGGAGAAAGGATATGAGGAGTGGT
CTATGTTGACCTCCCTTCTTTTTTCACCCAGTTGCCTTTAAACCAGACTCTAAACAGCCGGTCT
CCAGGTAGAAAGGAGGCTTGGCTGTATCCTGTTGAGACGGGACTGTCTGGTCTCATTTCCCTCT
CTACCTTCCAAGCTACCCTTTCTCCTGCTAACCCTTCTCAGCTCTAAGGGTTGGAGTCATAACT
CACATTCTTCATTCCTAAGAATCTGGAGCTAGCTGTTTGCCTTTGACTCCCTGACTTCAAGCCA
GGGTTGTGCCTTACTGTCCCTTTTCTGGGCCTCATTCTGCCAAAGCTGGACCAAGGTTCCACCT
TTCTAAGCTCCCTAGCTCAGAGGCCAAAAATGAAAGCTGAGCTACTTTTAACTTTTTCTCTTCC
TTAACTACAAGTCAATTAAGTGAAGGAGGGTATACATGCCCTCACCCTACCCCAGGGACCATGG
TTCCTAGATCTCACTGCCTCCTATTTCTGGCCTCCCTTTTCCCCTCCCTTCAGCTAAGACAAGC
TGGTGTGGAGTAGAAGGGCAACTAGTTCTGTTATTTATTGAACATTTGGGGTTTCAGTTGCAAA
GCCAGAACTACAGCTACCTGGCATTTCGGCGAGGGACCATTTCAGACCAAAATGTACTGTTAAT
TTTTTTTAATTAAAGTATATTAAAGGTTAAATAAAACAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006232887 ⟹ XP_006232949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,580,731 - 185,587,789 (+)	NCBI
mRatBN7.2	2	182,893,111 - 182,898,805 (+)	NCBI
Rnor_6.0	2	196,488,878 - 196,495,930 (+)	NCBI
Rnor_5.0	2	215,986,084 - 215,994,362 (+)	NCBI

Sequence:

show sequence

TGCGTTTATGTGTGTGTTGCTCCTTGTTGTCTATTGCTGCCTCATACCCCTCTATTCTCACTGG
GGTCTCTGGCCCGGTTTCTCTCTGGGAAGAGGGACTTTCCCCCTCTGTCGTTGGCCATAGGCAA
ACTGACACTATACAGTTCTTTCAGCACCATCCCACTTGCAGCTGCTACTTCAACCTACTGGTCT
CTCCAGTCTCTTGGAGGCATACTTTTATACAGTGTTTGTGAAACATCCCAGAGAAGTGGCAGGC
CACGTGAAGCCTGAGGCCACAGTTGTCACAGCCTCACCTCCTTACCTTCCCCAGAATCTGACCC
ATAGCTTTGGCTGTGCTGTAGCCTGAAGCAGTTGACACACCTTTTGACTTCTGTTGCTTCTAGG
CGGTGGGGTGTCTAGAAAGAAGTTCATGGCCAGCTACTATTACCCGAAAAGAAAATTTTCAAAA
GTCTACTTAGGACTATGTCGCCTTTTCCATGTTTGCTCAGGCTCGAGAGCCTATGAAACTGTCT
CTTTCAGTCTATCTGCCGTCCCACTGGGTCTGCGGTTTTCTTGTAGGTTAAGTGTCTACCCTCC
CAGCCTTCTGGGTCTGTAAGCACCCATCTCTCACCCCTTTTCACTTGCGTCGGAGGGTCTTTGA
GTGGAGGATCAGTCAGAGTTGGAGCCGAGGTTGGAGTCAGGCAAGAACCCTGCTTAAGTTTCGA
GTAATATGATGCTTGTGAAATCCATGCTGTACTGGCTCCTCGTCCGCCTGTGTCTCGGAAAGTG
GTGCCCGTCTCTGAGGCAGGCACGTGTGAGGAACACATAGATGGACACCATGCCAGATCTCTTC
ATGTGTGTGGGCGGTATAATTTTTGTGAGTGGAAAAGTTGCAGGTGTAATCAAGTTGCAGGTGT
AATCAAGGTGTAATCAGCCCTTAGGGGCTGGATGTCGCCCTCTCTTGTCCTGATTTCTTATTGA
TGGAATGCTTTGTCTGGTGTGCTGGTGCCAAGTAGCCACGAGGGGCGCAGCAGGGAGCAGACTG
GCTCTGTGGAGGTGTGTAAGGCTGACTGGAAACCCCAGTCCCTTCTCCTGTTGAGTTAAAAGTC
TTGACTTTGCTGCATCTCGTGGAAATTCAGAACAGCAAAGACGGACACAGCAAGCTTGAAGCCC
AGCGTGCAGGCCCCCAGCAGTCTTCACTCTCCAGTGACAGTGGGAGAGCGCTGGGGCTGCTGTC
CTGGGGTTGAAATAGGTGTGCTCTTCAGTGATACCCAGTTGGGCTACCCAACCCCCACCCTCTA
GCTCCTTACCTTCTTTGTAGGGATAAGGAAGGCACTAGACATTCCTACGCCGCTGGAGCCCAGA
GGAGAGGCTCCACCCACTCCCTGGGCCCTTGCTAGCTCTGAGTCTTTAACCCTCAAAAGACTCT
ATCAAGAAAAATATCCTAGTAATGGAATGGCATGGAGATAGCCCAAGGCTAGGATTACCTGCAT
GCTTGACTTTAGGTCTCATTGAAGAAAGAGATAGGCACACAGTAGCCAGGAGACAAGGTCAGGT
ACTGACTGGTCCCTACCTCCTATCTAGTTAACCCAAAGGTAGGAAGGAGGCGGTGGGGTGTCCA
GATTGCACCTTCACTTGGCCTTCTCCTTCCTCTAGGGAGAAAGTGTGCTTGCGTGGGCAGTTAT
ATTTAATTCTGTCCTTTGGAGAGGCTTCCACTCTATTTGACAAACTAAATATTTATTCAGGTTG
AGGTGGAGGGGAACGGACAGTGCTCTCCATGTTGGGGCCTGGAATGTATAACTGGGATGTGTGT
GCCGTGTGTGCAGCTGAAATCCTTTATCATCTATGCTGACCTCTGAGTTCATCCAAAAGAGCAG
TGAGCAGGAGTGGGGACAAGAGGGTAAAGTCCTTGAGCTGGAAGGAGTACTGACTGACCTGTGA
CATGCTGAGAGGGATTTCGCAAGTGCTTCTGTGGAGGGTGGGGGCGGAGCTGGCGAGAGAGCCA
ACCAAACCTAGGGGCAGCCTAGCTCAGCTGTGAGCTGAGGGTTCCACCTCCTTCAGCAACTCGG
TATTTAGTGCCTGGTGCCTCTGCCCACGTTGGTCCACAGGCTGCTGCTCCATTCCTCTCCACCT
GAGAGACCACCTTCCTCCTAGTCATAGTCTCTAGGATGCTCCAGACCTTGTATGACTACTTCTG
GTGGGAACGACTATGGCTGCCTGTGAACTTAACCTGGGCTGATCTAGAAGACAAAGATGGACGT
GTCTATGCCAAAGCCTCAGACCTCTACATCACACTACCCCTGGCCCTGCTCTTTCTCATCATTC
GATACTTCTTTGAGCTTTATGTGGCTACACCCCTGGCTGCCCTCCTGAATGTTAAGGAGAAAAC
CCGACTGCGGGCACCTCCCAATGCCACCTTAGAGCATTTCTACCTGACCGTCGGCAAGCAGCCC
AAGCAGGTGGAGGTAGACCTTTTGTCTCGGCAGAGTGGGCTCTCTGGACGCCAGGTAGAACGTT
GGTTCCGCCGCCGCCGCAACCAGGACAGGCCCAGTCTTCTCAAGAAGTTCCGAGAAGCCAGCTG
GAGATTCACATATTACCTCATTGCCTTTGTTGCTGGCATGGCTGTCACTGTGGATAAACCCTGG
TTCTATGACTTGAGGAAAGTTTGGGAAGGATATCCCATACAGAGTATCATCCCTTCTCAGTATT
GGTACTACATGATTGAGCTTGCTTTCTACTGGTCCCTGCTCTTCAGCATTGCCTCCGATGTCAA
GCGAAAGGATTTTAAGGAACAGATCATCCACCATGTGGCCACCATCATTCTCCTCTGCTTCTCC
TGGTTTGCCAATTATGTCCGAGCAGGGACCCTCATCATGGCTCTGCATGACTCTTCCGACTACC
TGCTGGAGTCTGCCAAGATGTTTAACTACGCAGGATGGAAAAACACCTGCAACAACCTCTTCAT
TGTCTTCGCCGTCGTTTTCATCATCACTCGACTGGTTATCATGCCCTTCTGGATCCTCCACTGC
ACAATGATATACCCACTGGAGTTCTACCCTGCCTTCTTTGGCTATTACTTCTTCAATTCCATGA
TGGTAGTGCTACAGATGCTCCATGTCTTCTGGGCCTACTTCATTGTGCGCATGGCCCACAAGTT
CATAACTGGAAAGCTGGTAGAAGATGAACGCAGTGACAGAGAAGAAACAGAGAGTTCAGAGGGG
GAGGAGGCTGCAGCTGGGGCAGGAGCAAAGAGCCGACTCCTAGCTAATGGCCACCCCATCCTCA
ATAACAACCATCCTAAGAATGACTGAACCGTTGTCCTAGCTGCCTCCCACATCAATACGCGAAG
CCAAGAAACTAGCCAAGCTTCCCTGTAGGGGCATTTGAGCTCTGGGGAGAAAGGATATGAGGAG
TGGTCTATGTTGACCTCCCTTCTTTTTTCACCCAGTTGCCTTTAAACCAGACTCTAAACAGCCG
GTCTCCAGGTAGAAAGGAGGCTTGGCTGTATCCTGTTGAGACGGGACTGTCTGGTCTCATTTCC
CTCTCTACCTTCCAAGCTACCCTTTCTCCTGCTAACCCTTCTCAGCTCTAAGGGTTGGAGTCAT
AACTCACATTCTTCATTCCTAAGAATCTGGAGCTAGCTGTTTGCCTTTGACTCCCTGACTTCAA
GCCAGGGTTGTGCCTTACTGTCCCTTTTCTGGGCCTCATTCTGCCAAAGCTGGACCAAGGTTCC
ACCTTTCTAAGCTCCCTAGCTCAGAGGCCAAAAATGAAAGCTGAGCTACTTTTAACTTTTTCTC
TTCCTTAACTACAAGTCAATTAAGTGAAGGAGGGTATACATGCCCTCACCCTACCCCAGGGACC
ATGGTTCCTAGATCTCACTGCCTCCTATTTCTGGCCTCCCTTTTCCCCTCCCTTCAGCTAAGAC
AAGCTGGTGTGGAGTAGAAGGGCAACTAGTTCTGTTATTTATTGAACATTTGGGGTTTCAGTTG
CAAAGCCAGAACTACAGCTACCTGGCATTTCGGCGAGGGACCATTTCAGACCAAAATGTACTGT
TAATTTTTTTTAATTAAAGTATATTAAAGGTTAAATAAAACATGACTGTGTCAGACTA

hide sequence

RefSeq Acc Id:

XM_006232888 ⟹ XP_006232950

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,579,656 - 185,587,789 (+)	NCBI
mRatBN7.2	2	182,890,780 - 182,898,805 (+)	NCBI
Rnor_6.0	2	196,487,909 - 196,495,930 (+)	NCBI
Rnor_5.0	2	215,986,084 - 215,994,362 (+)	NCBI

Sequence:

show sequence

GGCCTCGGCCCAGAGAAGGCCTGTGGGGCAACAGGATGCTCCAGACCTTGTATGACTACTTCTG
GTGGGAACGACTATGGCTGCCTGTGAACTTAACCTGGGCTGATCTAGAAGACAAAGATGGACGT
GTCTATGCCAAAGCCTCAGACCTCTACATCACACTACCCCTGGCCCTGCTCTTTCTCATCATTC
GATACTTCTTTGAGCTTTATGTGGCTACACCCCTGGCTGCCCTCCTGAATGTTAAGGAGAAAAC
CCGACTGCGGGCACCTCCCAATGCCACCTTAGAGCATTTCTACCTGACCGTCGGCAAGCAGCCC
AAGCAGGTGGAGGTAGACCTTTTGTCTCGGCAGAGTGGGCTCTCTGGACGCCAGGTAGAACGTT
GGTTCCGCCGCCGCCGCAACCAGGACAGGCCCAGTCTTCTCAAGAAGTTCCGAGAAGCCAGCTG
GAGATTCACATATTACCTCATTGCCTTTGTTGCTGGCATGGCTGTCACTGTGGATAAACCCTGG
TTCTATGACTTGAGGAAAGTTTGGGAAGGATATCCCATACAGAGTATCATCCCTTCTCAGTATT
GGTACTACATGATTGAGCTTGCTTTCTACTGGTCCCTGCTCTTCAGCATTGCCTCCGATGTCAA
GCGAAAGGATTTTAAGGAACAGATCATCCACCATGTGGCCACCATCATTCTCCTCTGCTTCTCC
TGGTTTGCCAATTATGTCCGAGCAGGGACCCTCATCATGGCTCTGCATGACTCTTCCGACTACC
TGCTGGAGTCTGCCAAGATGTTTAACTACGCAGGATGGAAAAACACCTGCAACAACCTCTTCAT
TGTCTTCGCCGTCGTTTTCATCATCACTCGACTGGTTATCATGCCCTTCTGGATCCTCCACTGC
ACAATGATATACCCACTGGAGTTCTACCCTGCCTTCTTTGGCTATTACTTCTTCAATTCCATGA
TGGTAGTGCTACAGATGCTCCATGTCTTCTGGGCCTACTTCATTGTGCGCATGGCCCACAAGTT
CATAACTGGAAAGCTGGTAGAAGATGAACGCAGTGACAGAGAAGAAACAGAGAGTTCAGAGGGG
GAGGAGGCTGCAGCTGGGGCAGGAGCAAAGAGCCGACTCCTAGCTAATGGCCACCCCATCCTCA
ATAACAACCATCCTAAGAATGACTGAACCGTTGTCCTAGCTGCCTCCCACATCAATACGCGAAG
CCAAGAAACTAGCCAAGCTTCCCTGTAGGGGCATTTGAGCTCTGGGGAGAAAGGATATGAGGAG
TGGTCTATGTTGACCTCCCTTCTTTTTTCACCCAGTTGCCTTTAAACCAGACTCTAAACAGCCG
GTCTCCAGGTAGAAAGGAGGCTTGGCTGTATCCTGTTGAGACGGGACTGTCTGGTCTCATTTCC
CTCTCTACCTTCCAAGCTACCCTTTCTCCTGCTAACCCTTCTCAGCTCTAAGGGTTGGAGTCAT
AACTCACATTCTTCATTCCTAAGAATCTGGAGCTAGCTGTTTGCCTTTGACTCCCTGACTTCAA
GCCAGGGTTGTGCCTTACTGTCCCTTTTCTGGGCCTCATTCTGCCAAAGCTGGACCAAGGTTCC
ACCTTTCTAAGCTCCCTAGCTCAGAGGCCAAAAATGAAAGCTGAGCTACTTTTAACTTTTTCTC
TTCCTTAACTACAAGTCAATTAAGTGAAGGAGGGTATACATGCCCTCACCCTACCCCAGGGACC
ATGGTTCCTAGATCTCACTGCCTCCTATTTCTGGCCTCCCTTTTCCCCTCCCTTCAGCTAAGAC
AAGCTGGTGTGGAGTAGAAGGGCAACTAGTTCTGTTATTTATTGAACATTTGGGGTTTCAGTTG
CAAAGCCAGAACTACAGCTACCTGGCATTTCGGCGAGGGACCATTTCAGACCAAAATGTACTGT
TAATTTTTTTTAATTAAAGTATATTAAAGGTTAAATAAAACATGACTGTGTCAGACTA

hide sequence

RefSeq Acc Id:

XM_039102354 ⟹ XP_038958282

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,580,731 - 185,587,789 (+)	NCBI
mRatBN7.2	2	182,893,935 - 182,898,805 (+)	NCBI

RefSeq Acc Id:

XM_039102355 ⟹ XP_038958283

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,579,900 - 185,587,789 (+)	NCBI
mRatBN7.2	2	182,891,208 - 182,898,805 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001028872	(Get FASTA)	NCBI Sequence Viewer
	XP_006232949	(Get FASTA)	NCBI Sequence Viewer
	XP_006232950	(Get FASTA)	NCBI Sequence Viewer
	XP_038958282	(Get FASTA)	NCBI Sequence Viewer
	XP_038958283	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI01877	(Get FASTA)	NCBI Sequence Viewer
	EDL85715	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028699
	ENSRNOP00000028699.2
	ENSRNOP00000073283.1

RefSeq Acc Id:

NP_001028872 ⟸ NM_001033700

- UniProtKB:

G3V8V4 (UniProtKB/TrEMBL), Q3T1K1 (UniProtKB/TrEMBL), A6K2Y5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLQTLYDYFWWERLWLPVNLTWADLEDKDGRVYAKASDLYITLPLALLFLIIRYFFELYVATPL
AALLNVKEKTRLRAPPNATLEHFYLTVGKQPKQVEVDLLSRQSGLSGRQVERWFRRRRNQDRPS
LLKKFREASWRFTYYLIAFVAGMAVTVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELAFYWS
LLFSIASDVKRKDFKEQIIHHVATIILLCFSWFANYVRAGTLIMALHDSSDYLLESAKMFNYAG
WKNTCNNLFIVFAVVFIITRLVIMPFWILHCTMIYPLEFYPAFFGYYFFNSMMVVLQMLHVFWA
YFIVRMAHKFITGKLVEDERSDREETESSEGEEAAAGAGAKSRLLANGHPILNNNHPKND

hide sequence

RefSeq Acc Id:	XP_006232950 ⟸ XM_006232888
- Peptide Label:	isoform X1
- UniProtKB:	G3V8V4 (UniProtKB/TrEMBL), A6K2Y5 (UniProtKB/TrEMBL), Q3T1K1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLQTLYDYFWWERLWLPVNLTWADLEDKDGRVYAKASDLYITLPLALLFLIIRYFFELYVATPL AALLNVKEKTRLRAPPNATLEHFYLTVGKQPKQVEVDLLSRQSGLSGRQVERWFRRRRNQDRPS LLKKFREASWRFTYYLIAFVAGMAVTVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELAFYWS LLFSIASDVKRKDFKEQIIHHVATIILLCFSWFANYVRAGTLIMALHDSSDYLLESAKMFNYAG WKNTCNNLFIVFAVVFIITRLVIMPFWILHCTMIYPLEFYPAFFGYYFFNSMMVVLQMLHVFWA YFIVRMAHKFITGKLVEDERSDREETESSEGEEAAAGAGAKSRLLANGHPILNNNHPKND hide sequence

RefSeq Acc Id:	XP_006232949 ⟸ XM_006232887
- Peptide Label:	isoform X1
- UniProtKB:	G3V8V4 (UniProtKB/TrEMBL), A6K2Y5 (UniProtKB/TrEMBL), Q3T1K1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLQTLYDYFWWERLWLPVNLTWADLEDKDGRVYAKASDLYITLPLALLFLIIRYFFELYVATPL AALLNVKEKTRLRAPPNATLEHFYLTVGKQPKQVEVDLLSRQSGLSGRQVERWFRRRRNQDRPS LLKKFREASWRFTYYLIAFVAGMAVTVDKPWFYDLRKVWEGYPIQSIIPSQYWYYMIELAFYWS LLFSIASDVKRKDFKEQIIHHVATIILLCFSWFANYVRAGTLIMALHDSSDYLLESAKMFNYAG WKNTCNNLFIVFAVVFIITRLVIMPFWILHCTMIYPLEFYPAFFGYYFFNSMMVVLQMLHVFWA YFIVRMAHKFITGKLVEDERSDREETESSEGEEAAAGAGAKSRLLANGHPILNNNHPKND hide sequence

RefSeq Acc Id:

ENSRNOP00000073283 ⟸ ENSRNOT00000080324

RefSeq Acc Id:

ENSRNOP00000028699 ⟸ ENSRNOT00000028699

RefSeq Acc Id:	XP_038958283 ⟸ XM_039102355
- Peptide Label:	isoform X1
- UniProtKB:	G3V8V4 (UniProtKB/TrEMBL), A6K2Y5 (UniProtKB/TrEMBL), Q3T1K1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958282 ⟸ XM_039102354
- Peptide Label:	isoform X1
- UniProtKB:	G3V8V4 (UniProtKB/TrEMBL), A6K2Y5 (UniProtKB/TrEMBL), Q3T1K1 (UniProtKB/TrEMBL)

Protein Domains

Homeobox TLC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3T1K1-F1-model_v2	AlphaFold	Q3T1K1	1-385	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691546

Promoter ID:

EPDNEW_R2071

Type:

initiation region

Name:

Cers2_1

Description:

ceramide synthase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	196,487,672 - 196,487,732	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310059	AgrOrtholog
BioCyc Gene	G2FUF-52098	BioCyc
Ensembl Genes	ENSRNOG00000021138	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000028699	ENTREZGENE
	ENSRNOT00000028699.5	UniProtKB/TrEMBL
	ENSRNOT00000080324.2	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5620921	IMAGE-MGC_LOAD
InterPro	Homeodomain	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
	Longevity_assurance_LAG1_LAC1	UniProtKB/TrEMBL
	TLC-dom	UniProtKB/TrEMBL
KEGG Report	rno:310667	UniProtKB/TrEMBL
MGC_CLONE	MGC:124761	IMAGE-MGC_LOAD
NCBI Gene	310667	ENTREZGENE
PANTHER	CERAMIDE SYNTHASE 2	UniProtKB/TrEMBL
	PTHR12560	UniProtKB/TrEMBL
Pfam	TRAM_LAG1_CLN8	UniProtKB/TrEMBL
PhenoGen	Cers2	PhenoGen
PIRSF	LAG1_LAC1	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_2	UniProtKB/TrEMBL
	TLC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021138	RatGTEx
SMART	TLC	UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain_like	UniProtKB/TrEMBL
UniProt	A6K2Y5	ENTREZGENE, UniProtKB/TrEMBL
	G3V8V4	ENTREZGENE, UniProtKB/TrEMBL
	Q3T1K1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-02	Cers2	ceramide synthase 2	Lass2	LAG1 homolog, ceramide synthase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-11	Lass2	LAG1 homolog, ceramide synthase 2	Lass2	longevity assurance homolog 2 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Lass2	longevity assurance homolog 2 (S. cerevisiae)	Lass2_predicted	longevity assurance homolog 2 (S. cerevisiae) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lass2_predicted	longevity assurance homolog 2 (S. cerevisiae) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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